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Bruker at Virtual US HUPO 2021

Bruker at Virtual US HUPO

Join us for the Bruker virtual seminar at US HUPO 2021

Join Bruker's Virtual Seminar on March 9th during the US HUPO Virtual Conference being held March 8 - 12, 2021. Below are the details for the talks taking place.  We hope you will join us.  Also be sure to click the “Posters” tab to see the latest from Bruker’s Mass Spec application’s team.

Tuesday, March 9 – 11:00 am PST/2:00 pm EST

Talk title: Plasma proteomics during a pandemic with a focus on COVID-19 and trauma patients

Abstract:
Over 100 million people around the world have tested positive for the beta coronavirus SARS-CoV-2 from late 2019 to February 1st, 2021. COVID-19 has been characterized by elevated mortality with approximately 2.24 million deaths, primarily due to thrombo-inflammatory complications that impair lung perfusion and systemic oxygenation in the most severe cases. Over the same time period we developed a plasma proteomics pipeline using the Evosep One and timsTOF Pro system to explore systemic alterations in numerous injury and disease states. Similarities between COVID-19 and trauma, the number one cause of death for individuals under 45 with approximately 5.8 million annual deaths worldwide, lead to the exploration of a therapeutic intervention that activates the fibrinolytic system.


*in order to participate with the US HUPO conference and workshops, you must be registered with US HUPO
 

Speaker

Kirk Hansen, PhD
Professor, University Colorado
CU Anschutz
Biochemistry and Molecular Genetics

Dr. Kirk C. Hansen is a world-leading expert in the field of quantitative and extracellular matrix proteomics. Former UCSF and CalTech alumnus, over the past decade Dr. Hansen and his lab have invested in the development and translational application of analytical strategies for the detection and quantification of proteins in health and disease, with a particular focus on the extracellular matrix. As Director of the University of Colorado, School of Medicine, Proteomics Facility Dr. Hansen has collaborated with a wide range of scientists and clinicians on a diverse set of research and clinical projects. This effort has resulted in over one hundred publications in less than 6 years.

Talk title: Real-time search using PaSER and the extended capabilities of the timsTOF Pro

Abstract:
Computationally, real-time database search in proteomics has been difficult because the time to search and assign a fragment ion spectrum to a peptide sequence can take longer than the rate of acquisition. This is particularly true when the search space is large including PTMs or semi-specific search parameters. Here, using massively parallelized search capabilities on a GPU called PaSER we can effectively perform the database search at the same rate as data acquisition, even under difficult search parameters including PTMs and enyme specificity. Additionally, in this talk we will describe the extended capabilities of the timsTOF Pro in prm-PASEF and dia-PASEF modes.  

Speaker

Chris Adams, PhD
Business Development Bioinformatics,
Bruker Daltonics

Chris Adams is the Business Development Director Bioinformatics for Bruker Daltonics, where he has been since Feb. 2018. Prior to his time at Bruker Daltonics he was the Director of proteomics at the Stanford University Mass Spectrometry (SUMS) Laboratory where he had held increasing roles over 10 years. Chris received his PhD from Uppsala University, Sweden within the department of biological and medical mass spectrometry under the guidance of Professor Roman Zubarev. Prior to graduate school Chris worked at various research positions with Amgen and Baxter Biosciences. He is a Southern California native and in his free time enjoys outdoor activities with his wife, two daughters and dog that include boating and snow skiing.

Posters

Posters*

* PDF of each poster will be available to download at the start of the US HUPO virtual event.  Check back on March 8th

Abstract Number Title Focus
152 Combining the Accurate Mass and Time Tag approach and Ion Mobility to Find Missing Peptides Bioinformatics  
143 CCS-centric protein identification Bioinformatics
40 Proteomic profiling of IDH-mutant gliomas enables prediction of chromosomal copy number variations Quant
60 OpenTIMS, TimsPy, and TimsR: quick and friendly access to timsTOF Pro data Open Access Data
64 Implementation Of Holistic Glycopeptide PASEF-DDA Data In Diagnostics Glycopeptides
59 Evaluation of prmPASEF for multiplexed targeted proteomics PRM
54 Quantitative proteomics analysis of urine samples from COVID-19 patients Quant COVID
37 Novel bifunctional material coupled to PASEF enables sensitive extracellular vesicles phosphoproteomic analysis of urine sample PTMs
36 A streamlined workflow for the quality control, interpretation and analysis of timsTOF Pro data: towards large-scale clinical proteomics Clincal
167 Computational simulation improves PASEF ion distribution and diaPASEF-based proteomics dia-PASEF
168 Draft Quantitative Proteomic Atlas of Human Body and Carcinoma Cancer Protoemics
124 Real-time search of Ubiquitin diGLY modified peptides and PaSER acquisition control PaSER
175 Predicting peptide CCS distributions with a Mixture Density Network Bioinformatics

Videos

Videos