Join Bruker's Virtual Seminar on March 9th during the US HUPO Virtual Conference being held March 8 - 12, 2021. Below are the details for the talks taking place. We hope you will join us. Also be sure to click the “Posters” tab to see the latest from Bruker’s Mass Spec application’s team.
Over 100 million people around the world have tested positive for the beta coronavirus SARS-CoV-2 from late 2019 to February 1st, 2021. COVID-19 has been characterized by elevated mortality with approximately 2.24 million deaths, primarily due to thrombo-inflammatory complications that impair lung perfusion and systemic oxygenation in the most severe cases. Over the same time period we developed a plasma proteomics pipeline using the Evosep One and timsTOF Pro system to explore systemic alterations in numerous injury and disease states. Similarities between COVID-19 and trauma, the number one cause of death for individuals under 45 with approximately 5.8 million annual deaths worldwide, lead to the exploration of a therapeutic intervention that activates the fibrinolytic system.
*in order to participate with the US HUPO conference and workshops, you must be registered with US HUPO
Kirk Hansen, PhD
Professor, University Colorado
Biochemistry and Molecular Genetics
Computationally, real-time database search in proteomics has been difficult because the time to search and assign a fragment ion spectrum to a peptide sequence can take longer than the rate of acquisition. This is particularly true when the search space is large including PTMs or semi-specific search parameters. Here, using massively parallelized search capabilities on a GPU called PaSER we can effectively perform the database search at the same rate as data acquisition, even under difficult search parameters including PTMs and enyme specificity. Additionally, in this talk we will describe the extended capabilities of the timsTOF Pro in prm-PASEF and dia-PASEF modes.
Chris Adams, PhD
Business Development Bioinformatics,
* PDF of each poster will be available to download at the start of the US HUPO virtual event. Check back on March 8th
|152||Combining the Accurate Mass and Time Tag approach and Ion Mobility to Find Missing Peptides||Bioinformatics|
|143||CCS-centric protein identification||Bioinformatics|
|40||Proteomic profiling of IDH-mutant gliomas enables prediction of chromosomal copy number variations||Quant|
|60||OpenTIMS, TimsPy, and TimsR: quick and friendly access to timsTOF Pro data||Open Access Data|
|64||Implementation Of Holistic Glycopeptide PASEF-DDA Data In Diagnostics||Glycopeptides|
|59||Evaluation of prmPASEF for multiplexed targeted proteomics||PRM|
|54||Quantitative proteomics analysis of urine samples from COVID-19 patients||Quant COVID|
|37||Novel bifunctional material coupled to PASEF enables sensitive extracellular vesicles phosphoproteomic analysis of urine sample||PTMs|
|36||A streamlined workflow for the quality control, interpretation and analysis of timsTOF Pro data: towards large-scale clinical proteomics||Clincal|
|167||Computational simulation improves PASEF ion distribution and diaPASEF-based proteomics||dia-PASEF|
|168||Draft Quantitative Proteomic Atlas of Human Body and Carcinoma||Cancer Protoemics|
|124||Real-time search of Ubiquitin diGLY modified peptides and PaSER acquisition control||PaSER|
|175||Predicting peptide CCS distributions with a Mixture Density Network||Bioinformatics|
For Research Use Only. Not for use in clinical diagnostic procedures.