Deconstruction of Vermal Cerebellum in Ramp Locomotion in Mice
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Discover how the brain encodes balance, posture, and speed
During this webinar, Dr. Xinjian Li discusses his work studying cerebellar activity during ramp locomotion in mice. Learn how Inscopix miniscopes overcome limitations of other imaging methods to image neuronal activity in the cerebellum of freely behaving animals.
Presenter’s Abstract
During this webinar, I discuss how the cerebellum is involved in encoding balance, posture, speed, and gravity during locomotion. Most studies have been carried out on flat surfaces, and little is known about cerebellar activity during free ambulation on slopes. I show how my group imaged the neuronal activity of cerebellar molecular interneurons (MLIs) and Purkinje cells (PCs) using the Inscopix miniscope while a mouse was walking on a slope, and how this study reveals a novel microcircuit in the vermal cerebellum that regulates ambulatory behavior in three-dimensional terrains.
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Speakers
Xinjian Li, Ph.D., Principal Investigator, Zhejiang University School of Medicine, Interdisciplinary Institute of Neuroscience and Technology