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Neurological study using BOLD/non-BOLD fMRI in rodents

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Webinar Overview

Functional MRI (fMRI) is a method for non-invasively measuring whole-brain neural activity via changes in the environment surrounding water molecule protons associated with neural activity. Recent developments in high-field MRI have enabled us to perform high-resolution fMRI measurements in rodent models. There are still issues to overcome in animal fMRI research, such as anesthesia, but it is expected to serve as a bridge research because of its usefulness in studying disease mechanisms, such as disease models by genetic modification and in combination with invasive measurements.

Tomokazu Tsurugizawa presents research results from the fusion of MRI and basic neuroscience research techniques (model animals, chemical genetics, electrophysiology, etc.). Furthermore, he introduces in addition to BOLD fMRI, diffusion fMRI and MEMRI, which are non-BOLD fMRI methods.

On Demand Session

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Speaker

Dr. Tomokazu Tsurugizawa
National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan

After obtaining his Ph.D. at the University of Tokyo in 2006, Dr. Tsurugizawa started a career in MRI research on the brain-gut axis using preclinical MRI at Ajinomoto Co. Inc in Japan. He developed an awake rat/mouse fMRI method and successfully visualized brain activity during nutrient perception in the rodent model. In 2014, he joined NeuroSpin, Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA)-Saclay, Gif-sur-Yvette, France, where he developed non-BOLD/BOLD fMRI in rodents using high-field MRI. In 2020, he moved to the University of Tsukuba and to the Institute of Advanced Industrial Science and Technology (AIST) in Japan. His interest is the translational study of the brain function and structure among rodents, macaque monkeys, and humans for understanding the mechanism of psychiatric disorders as well as cognitive function.

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