Webinar Overview
We have recently been working on two epilepsy models. The first model is a mesial temporal lobe epilepsy (MTLE) mouse model. We evaluated the benefits of multiparametric quantitative MRI, including both structural and perfusion data, and the benefits of GABA-edited spectroscopy, using first a single voxel, MEGA-PRESS, approach and then using spectroscopic imaging tools developed in house. These two approaches, which could be combined, could help delimit the epileptogenic area and thus improve the outcome of brain surgery in epileptic patients. The second model is a rat epilepsy-absence model, in whom we evaluated the benefit of conducting fMRI in awake animals, using a more silent, zero-echo time approach. Thereby, we could compare the brain response to visual stimuli during ictal and inter-ictal states. Altogether, preclinical MR appears as a powerful tool for characterizing the epileptogenic zone and for understanding how an epileptic seizure perturbs brain functions.
On Demand Session
Speaker
Dr. Emmanuel Barbier
Director, Grenoble Institute of Neurosciences
Dr. Barbier has a background in MRI physics. At the interface between physics and biology, he works on the development of MR imaging methods to characterize the brain microvasculature (arterial spin-labelling and susceptibility based approaches): blood flow, blood volume, blood-brain barrier permeability, vessel size/density, and tissue oxygen saturation. Dr. Barbier`s main fields of application are acute brain pathologies such as brain tumours and stroke but also other pathologies that involve the neurovascular unit such as epilepsia, in experimental models and in patients. Since 2021 he is the Director of IRMaGe facility at Grenoble Institut Neurosciences.