Powering the Next Era of Precision Mass Spectrometry with timsOmni^™ 

The timsOmni^™ represents a groundbreaking advancement in mass spectrometry, delivering unmatched sensitivity and versatility for deep proteoform sequencing and advanced structural elucidation. Designed for systems biology, it leverages multi-stage MSn eXd fragmentation, ion enrichment and precise electron energy modulation to achieve comprehensive molecular profiling. Key features include multimodal fragmentation for enhanced sequence coverage and fragment enrichment for high sensitivity. Its capabilities extend to native MS, top-down proteomics, oligonucleotide characterization and small molecule structural elucidation, making it ideal for advanced research projects. Built on the robust timsTOF platform, the timsOmni seamlessly transitions between bottom-up and top-down workflows, offering unparalleled performance for bottom-up analysis and complex biomolecule studies.

Duration time: 36 minutes

• Learn the benefits of trapped ExD
• Gain an understanding of the future of top-down and middle-down sequencing instrumentation
• Learn how to combine multiple MS/MS techniques such as EID, hECD, and CID to probe molecular structures

• Researchers interested advances in Top-down Sequencing hardware and software
• Scientists interested in alternative fragmentation techniques using Omnidirectional MSn combined with ion accumulation
• Investigators looking to exploit trapped ion mobility coupled with MSn capabilities for maximum structural information

Guillaume Tremintin,  Senior Technology Manager. Bruker