In this research highlight, Dr. Graves discusses his findings regarding the contribution of monoamine oxidase enzymes to mitochondrial oxidant stress and methamphetamine-induced neurodegeneration, as well as how his latest findings — enabled by multiphoton microscopy — have transformed the direction of his research.
"We've been using the two-photon system to examine mitochondrial oxidative stress in different neuronal populations, and different cellular compartments like axonal versus somatic to try and determine mechanisms underlying differential vulnerability of neurons to degeneration from a drug-induced insult."
ABOUT THE RESEARCHER:
Dr. Steven M. Graves is an Assistant Professor in the Department of Pharmacology and part of the Medical Discovery Team on Addiction at the University of Minnesota.
FIELD OF STUDY:
Dr. Graves' research program focuses on the pathogenesis of neurodegenerative diseases and drug-induced neurotoxicity. More specifically, he explores methamphetamine-induced neurodegeneration and the implications this has for developing neurodegenerative diseases such as Parkinson’s Disease.