Atomic Force Microscope

NanoWizard PURE

Streamlined design with best-in-class performance and flexibility

NanoWizard® PURE

The NanoWizard PURE atomic force microscope combines functionality and performance in a high-value instrument. Based on the renowned NanoWizard technology platform, it delivers high-resolution imaging and nanomechanical analysis capabilities that can be seamlessly combined with advanced optical microscopy techniques.

Easy upgrades and flexible configuration 
Extensive choice of modes, add-ons,  and accessories extend capabilities over a variety of applications.
Streamlined design, best in class functionality
Renowned hardware and software solutions, ideal for experienced users, newcomers, and multi-user imaging facilities.
Enhanced research capabilities
Seamless combination with advanced optics for precise correlated measurements and comprehensive analysis.

Performance in its Essence

Renowned quality

NanoWizard PURE delivers state-of-the-art functionality:

  • Unique 3D tip-scanning with capacitive sensor technology
  • PeakForce Tapping and QI modes for high-resolution imaging and advanced force control on delicate samples
  • Intuitive operation and automated routines, analysis, and data processing capabilities provided by latest V8 software environment

Unrivalled excellence in its class

Equipped with innovative hardware and software features, the NanoWizard PURE is ideal for laboratories wishing to expand their research capabilities with cutting-edge correlated microscopy techniques, whether for experienced users or those new to AFM.

The unparalleled modularity of the NanoWizard platform provides outstanding versatility. Its easy handling and user-friendliness make it deal for multi-user imaging facilities.

  • Discover attractive default configurations for biological and standard applications that offer best value solutions and capabilities
  • Keep apace of technological advances with new modules and features that match your research requirements
  • Upgrade paths to Bruker BioAFM premium NanoWizard product lines

Superior flexibility

NanoWizard PURE provides innovative research capabilities across a range of scientific fields, from the investigation of highly delicate biological samples, living cells, single molecules, and tissues, to the quantification of nanomechanical properties and study of polymers, soft matter, and advanced materials.

Correlated QI and optical images of live 3T3 fibroblast cells in cell culture medium at 37°C. Cell nuclei and actin fluorescently labelled with Hoechst 33342 and CellMask™ Green Actin Tracking, respectively. DirectOverlay semi-transparent superimposition of fluorescence images with optical phase contrast and QI scan. Scan size: 50μm × 70μm. Height range: 4μm (brown); Young’s modulus range: 20kPa (blue). Sample courtesy of Dr. Wedepohl, Freie Universität Berlin, Germany.

DNA nanostructures imaged with PeakForce Tapping in buffer using Bruker PEAKFORCEHIRS-F-B probe.
Scan size: 300nm × 300nm; Height range: 2nm.


PeakForce Tapping image of amyloid fiber Aβ(1-42) on mica in PBS with Bruker FASTSCAN-D probe.
Scan size: 650nm × 240nm; Height range: 10nm.

"NanoWizard PURE is a powerful system that can be seamlessly integrated with optical techniques. Its versatility makes it ideal for the routine and advanced nanomechanical analysis of samples as diverse as hydrogels, soft tissues, bone, and exoskeletons in our laboratory. It is a robust solution that provides reliable results and advances our understanding of mechanobiology in biological matter."

Asst. Prof. Meisam Asgari, University of South Florida, Tampa, USA

Outstanding Versatility and Range of Accessories

Maximum functionality

An extensive choice of modes, add-ons, and accessories provide additional capabilities over a wide variety of applications. NanoWizard PURE can be seamlessly combined with advanced optical techniques, such as confocal and super-resolution microcopy, and structured illumination techniques (SIM) for precise correlated measurements and enhanced analysis capabilities.

Explore a broad spectrum of features and options, such as:

  • Extensive optical integration options, e.g., DirectOverlay 2, DirectTiling, and accessories for operation on inverted optical microscopes
  • PeakForce QNM and QI advanced options for quantitative nanomechanical analysis
  • Force spectroscopy ramp designer 
  • ExperimentPlanner
  • Nanolithography and Nanomanipulation 
  • MFM, EFM
  • Latest ease-of-use features
NanoWizard PURE Bio (right) and Standard (left) configurations at attractive rates – see price list (Bio configuration shows optional accessories).
Stained peripheral nerve tissue from Mus musculus. DirectTiling of optical images superimposed with QI scan using DirectOverlay. Scan size: 100μm × 100μm. Height range: 50nm. Sample courtesy of Dr. Macgregor-Fairlie, Charité Berlin, Germany, & R. Doherty and C. Griffiths, University of Southampton, UK.

Enhanced adaptability

NanoWizard PURE can be customized to meet the specific demands of individual users, samples, and applications. It is ideal for interdisciplinary research facilities and collaborative scientific environments. Extend your research capabilities with options, such as:

  • Kelvin Probe Microscopy
  • Conductive AFM
  • Piezoresponse Force Microscopy
  • Cytosurge FluidFM® technology
  • Contact Resonance AFM
  • Scanning Tunneling Microscopy
  • Scanning Thermal AFM
  • Electrochemistry and SECM with temperature control and full optical access
  • Micropipette capabilities
New easy to use cantilever holder with hinge clip option, biocompatible and multicompartment compatible.

Piezoresponse Force Microscopy (PFM) of a ferroelectric polymer thin film (P(VDF-TrFE)) on a gold back electrode on silicon. A sequence of voltage pulses was generated from a bitmap template (black = +20V, white = 0V) to write the logo into the piezoelectric polarization of the sample. Scan size: 45μm × 10μm. Vertical PFM-amplitude range: 150pm. 


Magnetic Force Microscopy (MFM) scan of different magnetic domain patterns on a hard disc close to an intersector gap. Scan size: 8.5μm × 5.8μm MFM phase range: 2deg.

Selected Publications Using NanoWizard PURE Predecessor Systems:

  • Nasra, S. et al., Targeted Macrophage Re‐Programming: Synergistic Therapy With Methotrexate and RELA siRNA Folate‐Liposome in RAW264.7 Cells and Arthritic Rats. Adv Healthcare Materials 2400679 (2024). 
  • Wu, M. et al., Sustainable Microalgae Extraction for Proactive Water Bloom Prevention. Nat Water 2 (2), 172–182 (2024).
  • Muralidharan, V. et al., Preparation and Evaluation of Novel Biodegradable Kombucha Cellulose-Based Multi-Layered Composite Tableware. Industrial Crops and Products 215, 118629 (2024).
  • Barot, R. B. et al., Nanoparticles Derived from Bougainvillea Modulate Vegetative Growth via Auxin–Cytokinin Signaling in Arabidopsis. Chem. Pap. 2024. 
  • Zhang, E. et al., Mechanism Analysis of Lignin’s Effect on Asphalt’s Resistance to Moisture Damage. Journal of Cleaner Production, 434, 139425 (2024). 
  • Louros, N. et al, Local Structural Preferences in Shaping Tau Amyloid Polymorphism. Nat Commun 15 (1), 1028 (2024).
  • Bhadane, P. et al., Hydrolytically Stable Nanosheets of Cu-Imidazolate MOF for Selective Trapping and Simultaneous Removal of Multiple Heavy Metal Ions. Environ. Sci.: Nano 10.1039.D3EN00754E (2024).
  • Han, M. et al., Calcium Ions Have a Detrimental Impact on the Boundary Lubrication Property of Hyaluronic Acid and Lubricin (PRG-4) Both Alone and in Combination. Colloids and Surfaces B: Biointerfaces 234, 113741 (2024).
  • Nasra, S. et al., Bortezomib-Loaded Immunoliposomes against CD44 Expressing Macrophages: An Interplay for Inflammation Resolution. Nanoscale 16 (10) (2024).
  • Desroches, P. E. et al., Biphasic Nanocomposite Films of Polypyrrole and Poly(3,4-Ethylene Dioxythiophene) Using a Surface-Tethered Dopant Strategy. Electrochimica Acta 489, 144227 ( 2024). 
  • Abid, K. et al, A Study of Screen-Printed Electrodes Modified with MoSe2 and AuNPs-MoSe2 Nanosheets for Dopamine Sensing. Electrochimica Acta 475, 143371 (2024).
  • Singh, S. et al., Synergistic Effect of Yb 3+ , Tm 3+ , Nd 3+ Doped NaYF 4 Nanoparticles and MoS 2 Nanosheets for Enhanced Photocatalytic Dye Degradation under Visible Light. ACS Appl. Nano Mater. 6 (12), 10441–10452 (2023). 
  • Kang, M. et al., Surface and Conductivity Characterization of Layered Organic Ionic Plastic Crystal (OIPC)-Polymer Films. ACS Appl. Mater. Interfaces 15 (49), 57750–57759 (2023).
  • Newman, P. L. H. et al., Programming of Multicellular Patterning with Mechano‐Chemically Microstructured Cell Niches. Advanced Science 10 (15), 2204741 (2023). 
  • Zhang, C. et al., Mechanistic Formulation of Inorganic Membranes at the Air–Liquid Interface. Nature 616 (7956), 293–299 (2023).

The Widest Range of Accessories in the Market

Optical systems/accessories, electrochemistry solutions, electrical sample characterization, environmental control options, software modules, temperature control, acoustic and vibration isolation solutions and more. Bruker provides you with the right accessories to control your sample conditions and to perform successful experiments.  


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