Atomic Force Microscope

NanoWizard Sense+

Exceptional flexibility & modularity with proven NanoWizard technology


NanoWizard® Sense+

The NanoWizard Sense+ is a high-quality, entry level AFM, that enables AFM imaging with excellent resolution and highest mechanical and thermal stability, even on an inverted optical microscope.

Flexible configuration. Easy upgrades.
Ideal multi-user platform: Streamline your system to meet the needs of your users with a wide range of accessories and features. Combinable with advanced optics.
Entry level system with renowned quality
Unparalleled optical integration, superior imaging and resolution. Streamlined setup for increased productivity: Single-click calibration and novel, workflow-based software.
Highest mechanical and thermal stability
Multi-purpose system: Investigate living cells, single molecules, tissues, polymers, and nanomaterials.



The perfect start with leading technology

Based on the proven NanoWizard technology, the NanoWizard Sense+ delivers high performance measurements in air and liquid on samples ranging from single molecules, living cells and tissues to polymers and nanomaterials.

Thanks to its modular and flexible design, it can be easily upgraded to a full NanoWizard® 4 XP system with application-specific components and add-on features.

Piezoresponse Force Microscopy (PFM) of a ferroelectric copolymer.

Versatility, flexibility and modularity

Topography and Contact Resonance frequency images of a glass surface showing surface contamination from the production process.
Living Vero cells in cell culture medium. AFM image and overlay with phase contrast and fluorescence, taken using PeakForce Tapping® mode and the patented DirectOverlay™ 2 software feature.

The NanoWizard family is renowned for its wide range of optional accessories, modes and features, providing the highest flexibility for all your applications.

Sample handling: The large standard sample volume (Ø140×18mm3) can be enhanced with specialized options, such as motorized positioning, StretchingStage for AFM on samples under mechanical load, Head-up Stage extension up to 14cm in Z for taller samples, and shuttle stage for high NA upright optics with BioMAT™.

Temperature control: High and low temperature options (e.g., unique CryoStage: -120°C up to 220°C), with and without perfusion or gas control.

Open access: Utmost versatility in experiment design, e.g., simultaneous use of micro-pipettes or electrical probes in contact with the sample with AFM.

Electrical measurements: Conductive AFM, KPM, EFM, MFM, STM, Piezoresponse microscopy, electrochemistry with temperature control and optics.

Mechanical measurements: Optimized Force Mapping, Contact Resonance imaging, NanoManipulation, NanoLithography and NanoIndentation. Advanced Force Spectroscopy for applications ranging from single molecule force spectroscopy to viscoelastic mechanics.

Optical integration perfected: NanoWizard AFMs stand for unparalleled optical integration. Thanks to its unique tip-scanning design, the system can be combined with advanced optics and used simultaneously with standard condensers and reflection microscopy, even through thin coverslips, and on all major inverted optical microscopes.

Key Features

  • Designed for high quality imaging in air and liquid with excellent resolution, lowest noise and maximum usabilitys
  • Now with Bruker’s exclusive PeakForce Tapping as standard
  • Unique tip-scanning design and patented DirectOverlay™ 2 mode enable seamless integration with optical microscopy
  • Comprehensive force measurements from single molecules to living cells
  • New workflow-based user interface for ergonomics and ease of operation
  • Outstanding flexibility with a broad range of modes and accessories for the characterization of mechanical, electrical, optical, magnetic and chemical samples properties, including state-of-the-art FluidFM cantilevers for cell injection and manipulation
  • Can be easily upgraded to a full NanoWizard® 4 XP AFM system
NanoWizard 4 XP NanoScience setup with TopViewOptics, new user interface and tablet control.



NanoWizard Sense+ Data Gallery

Bruker’s BioAFMs allow life science and biophysics researchers to further their investigations in the fields of cell mechanics and adhesion, mechanobiology, cell-cell and cell-surface interactions, cell dynamics, and cell morphology. We have collected a gallery of images demonstrating a few of these applications.


Operating Modes

Standard Operating Modes

Imaging modes

  • Contact mode with lateral force microscopy (LFM)
  • Tapping Mode™ with PhaseImaging™

Force measurements

  • Static and dynamic spectroscopy
  • Advanced force mapping

Optional Modes

  • NEW: PeakForce Tapping
  • Higher harmonics imaging
  • NEW: Contact resonance AFM
  • Conductive AFM
  • Kelvin Probe Microscopy
  • MFM and EFM


  • STM
  • Electrical spectroscopy modes
  • Piezoresponse Microscopy
  • Electrochemistry with temperature control and optical microscopy
  • NanoLithography
  • NanoManipulation
  • Nanoindentation
  • Scanning Thermal AFM
  • NEW: FluidFM® solution from Cytosurge
  • ExperimentPlanner for designing a specific measurement workflow
  • RampDesigner™ for custom designed clamp and ramp experiments
  • ExperimentControl feature for remote experiment control
  • NEW: DirectOverlay 2 for combined AFM and optical microscopy



The Widest Range of Accessories in the Market

Optical systems/accessories, electrochemistry solutions, electrical sample characterization, environmental control options, software modules, temperature control, acoustic and vibration isolation solutions and more. Bruker provides you with the right accessories to control your sample conditions and to perform successful experiments.  



Watch Recent BioAFM Webinars

Our webinars cover best practices, introduce new products, provide quick solutions to tricky questions, and offer ideas for new applications, modes, or techniques.

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