MAS CryoProbes

With cryogenic cooling of the RF coil and the preamplifiers, the MAS CryoProbe enables solid-state NMR experiments with unprecedented signal-to-noise ratios, without the need for sample modification.

Unparalleled Sensitivity

New Science. Faster Experiments.

With the MAS CryoProbe, the signal-to-noise ratio is up to 10 times higher than with conventional room-temperature MAS probes.
The sample temperature is controlled independently, assuring optimal experimental conditions. No need to alter the sample composition.
Time Saving
The increased sensitivity of the MAS CryoProbe directly translates into shorter experiment times.

Increasing Sensitivity Without Sample Modification

While being extremely versatile, NMR has the inherent challenge of being insensitive. One strategy to improve the signal-to-noise ratio is to cryogenically cool the RF components of the NMR probe. The resulting reduced level of thermal noise generated by the RF coil, the network, and the preamplifiers leads to a significant boost in sensitivity while maintaining the sample in its original composition. While the RF components of the probe are cooled to cryogenic temperatures, the temperature of the sample can be controlled independently and kept close to room temperature to preserve the sample’s natural line width.

Bruker’s MAS CryoProbes are available in two RF configurations, with one geared towards biological research (HCN) and the other towards material research (HX). MAS CryoProbes are available for a range of different frequencies.

Download BioSolids MAS CryoProbe Flyer:

Download MAS CryoProbe for Material Science Flyer:


  • Cold preamplifiers for the observe channels
  • Strong RF fields for demanding solid-state NMR experiments
  • Integrated automatic tuning and matching
  • Precise and reproducible magic angle adjustment
  • Automated lift-assisted sample exchange
  • Sample temperature range: -20°C to +60°C
  • MAS rates up to 20 kHz with specially designed 3.2 mm rotors
  • Standard bore design, compatible with SB and WB magnets


  • Game changing sensitivity enhancement for solid-state NMR
  • Increased productivity through faster data acquisition
  • Expand resolution by adding one dimension in the same amount of experimental time:  4-dimensional experiments for structural elucidation, like CaNCOCX, recorded in just one week
  • Explore challenging dilute samples, preserving their natural chemical composition at physiologically relevant temperatures
  • 2D 13C-13C correlation experiments at natural abundance
  • 2D MQMAS correlation experiments on low gamma nuclei

BioSolids Applications

The HCN MAS CryoProbe addresses the specific needs of NMR spectroscopy of biological solids: challenging biological systems can be studied under physiological conditions, where their biological functions and mechanisms are retained.

The HCN MAS CryoProbe is a triple resonance MAS CryoProbe optimized for samples with moderate ionic strengths.

Diluted samples, such as labelled proteins in their native environment or small molecules in large assemblies, and samples in natural abundance or with a low level of labelling, benefit particularly from the significant sensitivity boost of this innovative probe.

Examples and links to references:

Material Science Applications

The double-channel HX MAS CryoProbe covers a large frequency range of nuclei which are relevant in material science. Material science applications that are inaccessible with conventional room-temperature probes are possible due to game-changing enhancements in sensitivity of the CryoProbe, particularly those involving low-gamma and low-natural-abundance nuclei.

Examples and links to references:

Pharmaceutical Applications

The MAS CryoProbe offers distinguished advantages when applied to routine experiments with crystalline materials: typical 1D 13C or 15N spectra require less than 20 minutes and just a few hours respectively, while a 2D 1H–13C HETCOR can be accomplished within an hour. 

Moreover, the 13C–13C and 1H–15N experiments, generally considered time-prohibitive using conventional room-temperature MAS probes, become feasible with the MAS CryoProbe. 

The MAS CryoProbe is a winning approach also in the characterization of pharmaceutical active ingredients into their formulation: the larger dispersion of the 13C and 15N chemical shift limits the detrimental effects of spectral crowding, and the boost in sensitivity achieved with the MAS CryoProbe maximizes the throughput.

Examples and references:


Bruker’s MAS CryoProbes are compatible with standard bore and wide bore magnets. Cryogenic cooling is provided by Bruker’s proven CryoPlatform. A fully motorized probe lift is used to move the MAS CryoProbe in and out of the magnet for easy and convenient sample changes. For such sample changes, the probe remains cold.

The MAS CryoProbe system package includes:

  • MAS CryoProbe​
  • Motorized probe lift, lift and magic angle motion control unit, and mounting hardware​
  • Special RT shim system, compatible with all standard bore probes​
  • Pump station for increased vacuum quality​
  • Spinning test station and packing tools specific for the MAS CryoProbe rotors.

Dr. Tobias Sparrman, Department of Chemistry, Umeå University, Sweden

With the astonishing sensitivity of our 3.2 mm HCN MAS CryoProbe for 600 MHz we enter a new world of possibilities for complex samples like membrane proteins and plant cell walls. I’m especially amazed by the DCP performance indicating not only the expected CryoProbe sensitivity gain but also a fantastic B1-homogeneity.

Dr. Miguel Mompeán, Instituto de Química Física "Blas Cabrera", IQF-CSIC, Spain

We conducted preliminary performance testing on the MAS CryoProbe ™: experiments that traditionally required overnight acquisition can now be completed within less than one hour and with an amazing signal-to-noise. The MAS CryoProbe exhibits exceptional capabilities and with this technology in our lab, we anticipate to achieve groundbreaking advancements in the emerging field of hybrid amyloids and their interactions and dynamics.

Dr. David Withall, Rothamsted Research, England, United Kingdom

We are thrilled to receive our new 700 MHz CP/MAS biosolids CryoProbe, which will enable us to make significant progress in crop protection and environmental research alongside other areas. Thanks to UKRI-BBSRC funding, the CryoProbe will be housed within our Chemical Ecology capability, and will help us answer critical questions about pest biology, crop and plant science, and environmentally-friendly pest management solutions.

Ordering Information

Available Frequencies Product Code

Double Resonance X/H 3.2 mm MAS CryoProbe

600 – 800 MHz (SB)


Triple Resonance C/N/H 3.2 mm BioSolids MAS CryoProbe

600 – 800 MHz (SB)


Please discuss required and recommended accessories (e.g. the MAS CryoProbe Lift or the CU/5 Cooling Unit) with your Bruker representative.