The SmartProbe™ delivers highest sensitivity on both the multinuclear and proton channel. Its design exclusively features a broadband frequency channel enabling fully automated applications on protons and the widest range of X-nuclei.
For maximum flexibility switching nuclei and probe tuning and matching is performed completely automatically using our ATM™ technology. A further key feature which those probes offer is the ability to observe 19F with 1H decoupling and to perform two-dimensional 1H/19F spectroscopy with superior quality. As two separate coils are used for these two nuclei, artifacts common with double tuning of one coil are eliminated.
The high performance Z-gradient has been designed for highest linearity and shortest gradient recovery times. Combined with its excellent line shape this probe facilitates superior single or multiple solvent suppression using presaturation or pulsed field gradients as required for samples from reaction control, biological samples and body fluids. The SmartProbe™ is the ideal probe for a wide range of applications from routine 1H NMR measurements on small molecules to advanced research applications including inverse experiments requiring excellent solvent suppression.
Applications for SmartProbe:
Boron is a common element used in inorganic and organic compounds. The spectra of decaborane show 11B-NMR spectra with and without proton decoupling. The 2D COSY was recorded in just a few minutes.
Structure verification and determination require high quality spectra, which are characterized by excellent lineshape for all nuclei and high sensitivity for all experiments. Well balanced rf channels and matched B1 homogeneity of all coils are a prerequisite, if best sensitivity is to be obtained for any type of application. Excellent solvent suppression enables applications in water, like biomolecular experiments and metabonomic studies.
Fluorine is an element found in many pharmaceutical compounds. Essential structural parameters are accessible with heteronuclear NOE experiments, like the HOESY experiment. Fluorine is also used as a spy for studies of the metabolism of active agents, and for enzymatic HTS screening.
(Top) 19F, 1H HMBC Experiment of cytostaticum fluorurazil. The correlation shows a spatial neighbourhood to the proton of the heterocycle.
(Bottom) Comparison of the 19F, 1H HOESY and HMBC experiment. While the HOESY spectrum has a correlation to the proton of the heterocycle, the HMBC shows a correlation to the NH protons.
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