rapifleX® MPP Publications

rapifleX® MALDI PharmaPulse® Publications 

Title Author Publication Link
A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1 Müller, L., et al. SLAS Discovery, 2023, 28, 3-11 https://doi.org/10.1016/j.slasd.2022.11.002
Differential Analyte Derivatization Enables Unbiased MALDI-TOF-based High-Throughput Screening: A Proof-of-Concept Study for the Discovery of Catechol-O-methyltransferase Inhibitors Winter, M., et al SLAS Discovery, 2022, 27(5), 287-297 https://doi.org/10.1016/j.slasd.2022.05.002
A MALDI-TOF assay identifies nilotinib as an inhibitor of inflammation in acute myeloid leukaemia Marín-Rubio, J.L., et al. bioRxiv 2022 https://doi.org/10.1101/2021.03.29.437557
Fast Nanoliter-Scale Cell Assays Using Droplet Microarray–Mass Spectrometry Imaging Ramallo Guevara, C., et al. Advanced Biology, 2021, 5(3) https://doi.org/10.1002/adbi.202000279
MALDI-TOF-Based Affinity Selection Mass Spectrometry for Automated Screening of Protein–Ligand Interactions at High Throughput Simon, R.P., et al. SLAS Discovery, 2021, 26(1), 44-57 https://doi.org/10.1177/2472555220959266
A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening. Benz, M., et al. Nature Communications 11, 2020, 5391 https://doi.org/10.1038/s41467-020-19040-0
Direct Automated MALDI Mass Spectrometry Analysis of Cellular Transporter Function: Inhibition of OATP2B1 Uptake by 294 Drugs Unger, M.S., et al. Anal. Chem. 2020, 92, 17, 11851–11859 https://doi.org/10.1021/acs.analchem.0c02186
MALDI-TOF Mass Spectrometry-Based High-Throughput Screening for Inhibitors of the Cytosolic DNA Sensor cGAS Simon, R.P., et al. SLAS Discovery, 2020, 25(4), 372-383 https://doi.org/10.1177/2472555219880185
High-throughput matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry–based deubiquitylating enzyme assay for drug discovery De Cesare, V., et al. Nat Protocol 15, 2020, 4034–4057 https://doi.org/10.1038/s41596-020-00405-0
Mechanistic MALDI-TOF Cell-Based Assay for the Discovery of Potent and Specific Fatty Acid Synthase Inhibitors Weigt, D., et al. Cell Chemical Biology, 2019, 26(9), 1322-1331 https://doi.org/10.1016/j.chembiol.2019.06.004
Chemical Derivatization Enables MALDI-TOF-Based High-Throughput Screening for Microbial Trimethylamine (TMA)-Lyase Inhibitors Winter, M., et al. SLAS Discovery, 2019, 24(7), 766-777 https://doi.org/10.1177/2472555219838216
Automated MALDI Target Preparation Concept: Providing Ultra-High-Throughput Mass Spectrometry–Based Screening for Drug Discovery Winter, M., et al. SLAS Technology, 2019, 24(2), 209-221 https://doi.org/10.1177/2472630318791981
Profiling embryonic stem cell differentiation by MALDI TOF mass spectrometry: development of a reproducible and robust sample preparation workflow Heap R. E., et al. Analyst, 2019, 144, 6371-6381 http://dx.doi.org/10.1039/c9an00771g
Mapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS Lin, S., et al. Science, 2018, 361(6402) https://doi.org/10.1126/Science.aar6236
Automated analysis of lipid drug response markers by combined fast and high-resolution whole cell MALDI mass spectrometry biotyping Weigt, D., et al. Scientific Reports 8, 2018, 11260 https://doi.org/10.1038/s41598-018-29677-z
Establishing MALDI-TOF as Versatile Drug Discovery Readout to Dissect the PTP1B Enzymatic Reaction Winter, M., et al. SLAS Discovery, 2018, 23(6), 561-573 https://doi.org/10.1177/2472555218759267
The MALDI-TOF E2/E3 Ligase Assay as UniversalTool for Drug Discovery in the Ubiquitin Pathway. De Cesare, V., et al. Cell Chemical Biology, 2018, 25(9), 1117-1127 https://doi.org/10.1016/j.chembiol.2018.06.004
Identification of Small-Molecule Noncovalent Binders Utilizing SAMDI Technology VanderPorten, E., et al. SLAS Discovery, 2017, 22(10), 1211-1217 https://doi.org/10.1177/2472555217712761
Integration of an In Situ MALDI-Based High-Throughput Screening Process: A Case Study with Receptor Tyrosine Kinase c-MET. Beeman, K., et al. SLAS Discovery, 2017, 22(10), 1203-1210 https://doi.org/10.1177/2472555217727701
Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs) Heap, R. E., et al. SLAS Discovery, 2017, 22(10), 1193-1202 https://doi.org/10.1177/2472555217717473
A Systematic Investigation of the Best Buffers for Use in Screening by MALDI–Mass Spectrometry Chandler, J., et al. SLAS Discovery, 2017, 22(10), 1262-1269 https://doi.org/10.1177/1087057116681726
The Evolution of MALDI-TOF Mass Spectrometry toward Ultra-High-Throughput Screening: 1536-Well Format and Beyond Haslam, C., et al. SLAS Discovery, 2016, 21(2), 176-186 https://doi.org/10.1177/1087057115608605
Screening of DUB activity and specificity by MALDI-TOF mass spectrometry Ritorto, M.S., et al. Nature Communications 5, 2014, 4763 https://doi.org/10.1038/ncomms5763


For Research Use Only. Not for use in clinical diagnostic procedures.