Atomic Force Microscopy Webinars

Optical Tweezers in Life Science: Probing DNA-protein interactions

with guest presenter: Davide Normanno, Staff Scientist, Center for Genomic Regulation, Barcelona, Spain

Watch On Demand

Learn About the Use of Optical Tweezers in Advanced Molecular and Cell Biology

In this webinar, Optical Tweezers in Life Science: Probing DNA-Protein Interactions at the Single-Molecule Level, our speakers discuss how optical tweezers methodology has developed from proof-of-principle experiments to an established quantitative technique in fields ranging from (bio)physics to cell biology.

The webinar focuses on applications of biological relevance and explores how the quantitative insights obtained using optical tweezers have advanced our understanding of the molecular mechanisms used by cells to repair their DNA and maintain their genome integrity — the cornerstone of cancer initiation and treatment.

Key Points

In this webinar, the speakers first explain how optical tweezers can be used to precisely micro-manipulate individual DNA molecules, then explore how they can be combined with single-molecule fluorescence imaging and micro-fluidics to perform cutting-edge DNA-protein interaction experiments with exquisite precision.

In particular, the webinar focuses on:

  1. Describing how the fragments of a broken DNA molecule are hold together during the repair process, and
  2. Comparing the connection forces exerted by different DNA-repair protein complexes.


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This webinar was presented on: May 28, 2020