Enhanced Hit Quality in High-Throughput Protein–Ligand Interaction Screening
Overview
In vitro measurement of small-molecule ligand binding to a protein target represents an important but challenging step in drug discovery.
A novel affinity-selection mass spectrometry (AS-MS) workflow has been developed to ensure enhanced hit quality at uncompromised speed in high-throughput screening (HTS) of protein–ligand interactions.
The new method uses trapped ion mobility spectrometry (TIMS) enabled MALDI mass spectrometry for label-free identification of ligands in a HTS compatible format.
Using data from a recent study, our expert speaker will demonstrate how the new readout platform improves ligand hit quality, and how TIMS offers potential for an expanded scope of AS-MS assays.
Watch this webinar to:
- Discover a novel AS-MS approach for enhanced HTS of protein–ligand interactions
- Learn how ligand hit quality is enhanced through improved AS-MS specificity
- Explore the unique potential TIMS offers for expanding the scope of AS-MS
- Learn about the latest technology behind AS-MS in HTS format
Speaker
Arndt Asperger, Ph.D., Senior Applications Scientist, High Throughput Screening MALDI Mass Spectrometry, Bruker Daltonics, Bremen, Germany
For Research Use Only. Not for use in clinical diagnostic procedures.