Acquifer HIVE
Data Management
Designed for the pragmatic, biology-focused scientist, the HIVE platform boosts productivity in microscopy facilities and screening labs. HIVE is a high speed centralized data repository that removes the need to constantly move or duplicate data sets in processing and analysis workflows. Its modular design integrates high speed processing, visualization, remote access, project management, flexibility, data security, scalability and ease of use in one unit. It saves time, space, costs and administrator workload.
HIVE Modules for Scalability
The Acquifer HIVE is a modular system with each module optimized for computation, storage, or networking. The four available standard modules include:
- DATA for fast and secure storage
- CORE for processing
- NET for communication, 10 Gbit/s connection to all your microscopes
- GPU for visualization, GPU processing and machine learning
Two add-on modules include:
- SAT for computation
- BACKUP for safety
HIVE Core
Acquifer HIVE combines processing computing power and storage, eliminating the need for data transfers and copying. This streamlined approach is supported by a dedicated high-bandwidth network with up to 200 Gbit speed, ensuring uninterrupted network traffic.
The HIVE works with virtually all supplier's microscopy instruments and processing software solutions, including Windows, Fiji, Knime, OMERO, Arivis Vision4D, Imaris, ZEN, LAS X, Nikon Elements, Huygens, Python, and CellProfiler.
This compatibility with systems and solutions guarantees wide usability across laboratory setups and research environments.
HIVE Data
Acquifer HIVE Data offers a range of highly scalable storage solutions designed for both speed and data safety. With storage units available from 52 to 234 TB, users can choose the configuration that best suits their data needs. The data transfer rate of 3 GB/s for internal input/output to the Acquifer HIVE Core ensures swift access and efficient data handling.
Acquifer HIVE Data prioritizes data security. The system is easily expandable through a plug-and-play extension and leveraging RAID technology. With 24/7 technology, HIVE Data provides reliable data access.
HIVE Net
HIVE ensures the utmost security of your data with several robust measures. RAID systems establish data protection by being distributed across multiple drives, reducing the risk of data loss in case of drive failures. A security firewall prevents unauthorized access by controlling network traffic. The Uninterruptible Power Supply (UPS) provides a continuous and stable power source that safeguards against power outages and potential data corruption.
HIVE can be accessed from wherever you are with a secure connection using remote desktops. The implementation of multi-user login allows for simultaneous collaborative work, which promotes efficiency and flexibility in data management and analysis.
HIVE GPU
The HIVE GPU proivdes unparalleled processing power for demanding applications. It uses NVIDIA's professional CUDA-capable boards for GPU-processing capabilities. Each HIVE GPU unit can accommodate up to 4 dual-slot GPUs, including the high-performance Quadro RTX A5000 and Quadro RTX A6000.
For those requiring extensive parallel computing capabilities, the Multi-Node Acquifer HIVE configuration is available.
HIVE Core stands out as a computing powerhouse, offering both flexibility and high-performance capabilities. It is an ideal solution for a wide range of applications in research, data analysis, and other compute-intensive tasks.
Published Application Research
| Year | Journal | Title | Author(s) | Subject |
|---|---|---|---|---|
| 2024 | Wiley - Light Sheet Fluorescence Microscopy | Light Sheet Fluorescence Microscopy | Emmanuel G. Reynaud, Pavel Tomančák | light-sheet book |
| 2024 | Toxicological Sciences | Corticosteroids alter kidney development and increase glomerular filtration rate in larval zebrafish (Danio rerio) | Jana Heigwer, Petrus J Steenbergen, Jochen Gehrig, Jens H Westhoff | zebrafish, corticosteroid, kidney, development, toxicology |
| 2024 | PhD Thesis Åbo Akademi University | Bioimage Analysis for Life Scientists: Tools for Live Cell Imaging | Joanna Pylvänäinen | image analysis, live cell imaging, experimental design, image processing, deep learning |
| 2023 | Journal of the American Society of Nephrology | A Novel High-Content Screening Assay Identified Belinostat as Protective in a FSGS—Like Zebrafish Model | Schindler Maximilian, Siegerist Florian, Lange Tim, Simm Stefan, Bach Sophia-Marie, Klawitter Marianne, Gehrig Jochen, Gul Sheraz, Endlich Nicole | zebrafish, screening, kidney, development, toxicology |
| 2023 | American Journal of Respiratory Cell and Molecular Biology | Local, Quantitative Morphometry of Fibroproliferative Lung Injury Using Laminin | Brendan P. Cox , Riley T. Hannan, Noora Batrash, Pearl Raichura, Anne I. Sperling, Yun Michael Shim, and Jeffrey M. Sturek | Fibrosis, histology, histopathology, imaging |
| 2020 | Cells | A multiparametric assay platform for simultaneous in vivo assessment of pronephric morphology, renal function and heart rate in larval zebrafish | Petrus J. Steenbergen, Jana Heigwer, Gunjan Pandey, Burkhard Tönshoff, Jochen Gehrig, and Jens H. Westhoff | screening pipeline, drug screening, experimental design , zebrafish |
| 2020 | Front. Cell Dev. Biol. | In vivo High-Content Screening in Zebrafish for Developmental Nephrotoxicity of Approved Drugs | Jens H. Westhoff, Jens H. Westhoff, Petrus J. Steenbergen, Laurent S. V. Thomas, Jana Heigwer, Bruckner Ledean Cooper, Burkhard Tönshoff, Georg F. Hoffmann, Jochen Gehrig | zebrafish, screening, kidney, pronephros, development, toxicology |
| 2020 | PhD Thesis Medizinischen Fakultät Heidelberg | Computer vision and data-analysis solutions for phenotypic screening of small model organisms | Laurent Thomas | phenotypic screening, software development, image analysis, object-detection |
| 2019 | IJMS | A smart imaging workflow for organ-specific screening in a cystic kidney zebrafish disease model | Gunjan Pandey, Jens H. Westhoff, Franz Schaefer, and Jochen Gehrig | kidney disease, intraflagellar transport, zebrafish, phenotypic screening |
Specifications
| Data Processing |
|
| Scalable High-Speed Storage |
|
| GPU Processing |
|
| Secure Project Managment |
|
| System Compatibility |
|
| * Acquifer HIVE is made to order based on your requirements. Later extensions and upgrades are easily implemented. | |
HIVE Dashboard
HIVE setup and maintenance is designed with end users in mind, meaning that users need no special expertise in software or hardware. This ease-of-use is maintained all while retaining secure project management.
HIVE Configurations
High Speed Microscope Example
- Lightsheet microscope
- Large format sCMOS
- Laser scanning
- confocal, Spinning disk, Screening microscope
- 3 HIVE modules recommended
Small Core Facility Example
- 1 to 2 rooms
- up to 5 microscopes
- replaces 3 image analysis workstations
- 3 HIVE modules recommended
Medium Core Facility Example
- 3 to 4 rooms
- 5 to 10 microscopes
- replaces 5 image analysis workstations
- 4-5 HIVE modules recommended (depending on microscopes)
Large Core Facility Example
- 4 to n rooms
- 15 microscopes
- replaces > 5 image analysis workstations
- 5-6 HIVE modules recommended (depending on microscopes)