Acquifer HIVE

Centralized Data Storage and Computing Solution

Data Management

Designed for the pragmatic, biology-focused scientist, the HIVE platform boosts productivity in microscopy facilities and screening labs. HIVE is a high speed centralized data repository that removes the need to constantly move or duplicate data sets in processing and analysis workflows. Its modular design integrates high speed processing, visualization, remote access, project management, flexibility, data security, scalability and ease of use in one unit. It saves time, space, costs and administrator workload.

Centralized
data storage
Offers microscopy image data management, accessible from wherever you are.
Compatible
instruments and software
Works with virtually all microscopy instrument suppliers and runs your processing software of choice.
Efficient
processing
Provides processing computing power and storage in one unit, requiring no data transfers and copying.
Features

HIVE Modules for Scalability

The Acquifer HIVE is a modular system with each module optimized for computation, storage, or networking. The four available standard modules include:

  • DATA for fast and secure storage
  • CORE for processing
  • NET for communication, 10 Gbit/s connection to all your microscopes
  • GPU for visualization, GPU processing and machine learning

Two add-on modules include:

  • SAT for computation
  • BACKUP for safety
Acquifer HIVE is a modular system, and its core modules are suited for computation, storage, and networking.
Data Processing

HIVE Core

Acquifer HIVE combines processing computing power and storage, eliminating the need for data transfers and copying. This streamlined approach is supported by a dedicated high-bandwidth network with up to 200 Gbit speed, ensuring uninterrupted network traffic.

The HIVE works with virtually all supplier's microscopy instruments and processing software solutions, including Windows, Fiji, Knime, OMERO, Arivis Vision4D, Imaris, ZEN, LAS X, Nikon Elements, Huygens, Python, and CellProfiler.

This compatibility with systems and solutions guarantees wide usability across laboratory setups and research environments.

Storage            

HIVE Data

Acquifer HIVE Data offers a range of highly scalable storage solutions designed for both speed and data safety. With storage units available from 52 to 234 TB, users can choose the configuration that best suits their data needs. The data transfer rate of 3 GB/s for internal input/output to the Acquifer HIVE Core ensures swift access and efficient data handling.

Acquifer HIVE Data prioritizes data security. The system is easily expandable through a plug-and-play extension and leveraging RAID technology. With 24/7 technology, HIVE Data provides reliable data access.

Communication

HIVE Net

HIVE ensures the utmost security of your data with several robust measures. RAID systems establish data protection by being distributed across multiple drives, reducing the risk of data loss in case of drive failures. A security firewall prevents unauthorized access by controlling network traffic. The Uninterruptible Power Supply (UPS) provides a continuous and stable power source that safeguards against power outages and potential data corruption.

HIVE can be accessed from wherever you are with a secure connection using remote desktops. The implementation of multi-user login allows for simultaneous collaborative work, which promotes efficiency and flexibility in data management and analysis.

Visualization

HIVE GPU

The HIVE GPU proivdes unparalleled processing power for demanding applications. It uses NVIDIA's professional CUDA-capable boards for GPU-processing capabilities. Each HIVE GPU unit can accommodate up to 4 dual-slot GPUs, including the high-performance Quadro RTX A5000 and Quadro RTX A6000.

For those requiring extensive parallel computing capabilities, the Multi-Node Acquifer HIVE configuration is available.

HIVE Core stands out as a computing powerhouse, offering both flexibility and high-performance capabilities. It is an ideal solution for a wide range of applications in research, data analysis, and other compute-intensive tasks.

Applications

Published Application Research

Year Journal Title Author(s) Subject
2024 Wiley - Light Sheet Fluorescence Microscopy Light Sheet Fluorescence Microscopy Emmanuel G. Reynaud, Pavel Tomančák light-sheet book
2024 Toxicological Sciences Corticosteroids alter kidney development and increase glomerular filtration rate in larval zebrafish (Danio rerio) Jana Heigwer, Petrus J Steenbergen, Jochen Gehrig, Jens H Westhoff zebrafish, corticosteroid, kidney, development, toxicology
2024 PhD Thesis Åbo Akademi University Bioimage Analysis for Life Scientists: Tools for Live Cell Imaging Joanna Pylvänäinen image analysis, live cell imaging, experimental design, image processing, deep learning
2023 Journal of the American Society of Nephrology A Novel High-Content Screening Assay Identified Belinostat as Protective in a FSGS—Like Zebrafish Model Schindler Maximilian, Siegerist Florian, Lange Tim, Simm Stefan, Bach Sophia-Marie, Klawitter Marianne, Gehrig Jochen, Gul Sheraz, Endlich Nicole zebrafish, screening, kidney, development, toxicology
2023 American Journal of Respiratory Cell and Molecular Biology Local, Quantitative Morphometry of Fibroproliferative Lung Injury Using Laminin Brendan P. Cox , Riley T. Hannan, Noora Batrash, Pearl Raichura, Anne I. Sperling, Yun Michael Shim, and Jeffrey M. Sturek Fibrosis, histology, histopathology, imaging
2020 Cells A multiparametric assay platform for simultaneous in vivo assessment of pronephric morphology, renal function and heart rate in larval zebrafish Petrus J. Steenbergen, Jana Heigwer, Gunjan Pandey, Burkhard Tönshoff, Jochen Gehrig, and Jens H. Westhoff screening pipeline, drug screening, experimental design , zebrafish
2020 Front. Cell Dev. Biol. In vivo High-Content Screening in Zebrafish for Developmental Nephrotoxicity of Approved Drugs Jens H. Westhoff, Jens H. Westhoff, Petrus J. Steenbergen, Laurent S. V. Thomas, Jana Heigwer, Bruckner Ledean Cooper, Burkhard Tönshoff, Georg F. Hoffmann, Jochen Gehrig zebrafish, screening, kidney, pronephros, development, toxicology
2020 PhD Thesis Medizinischen Fakultät Heidelberg Computer vision and data-analysis solutions for phenotypic screening of small model organisms Laurent Thomas phenotypic screening, software development, image analysis, object-detection
2019 IJMS A smart imaging workflow for organ-specific screening in a cystic kidney zebrafish disease model Gunjan Pandey, Jens H. Westhoff, Franz Schaefer, and Jochen Gehrig kidney disease, intraflagellar transport, zebrafish, phenotypic screening

Specifications

Data Processing
  • 2.2 GHz 12-core processor up to 2.6 GHz 2 x 64 core
  • 128 GB to 2 TB ECC memory
  • NVIDIA @ professional graphics cards with high-performance CUDA GPU with up to 48 GB memory
Scalable High-Speed Storage
  • Data collection rates of at least 800 MB/s
  • Internal data transfer rates of at least 3 GB/s
  • RAID 5 controlled primary storage of 10 TB SSD
  • RAID 6 storage of 52 to 234 TB data, can be combined to more than 1 PB
GPU Processing
  • Up to four dual slot GPUs per GPU module
  • PCIe x16 multiplexed
  • Up to three transparent HIVE extensions
Secure Project Managment
  • Latest generation 2048-bit encryption
  • Built-in DHCP server
  • Personalized access to a project, directory, and individual levels
System Compatibility
  • Products and software from 3i, Andor, Arivis, Bitplane, FEI, Fiji, Glencoe Software, Leica, Luxendo, Matlab, Nikon, SVI Huygens, and more
  • All microscope providers (Bruker, Zeiss, Leica, Olympus, Miltenyi, Nikon, etc.)
  • Virtual Machines (VM) and Linux solutions are available upon request
* Acquifer HIVE is made to order based on your requirements. Later extensions and upgrades are easily implemented.
Software

HIVE Dashboard

HIVE setup and maintenance is designed with end users in mind, meaning that users need no special expertise in software or hardware. This ease-of-use is maintained all while retaining secure project management.

MORE INFORMATION

HIVE Configurations

High Speed Microscope Example

  • Lightsheet microscope
  • Large format sCMOS
  • Laser scanning
  • confocal, Spinning disk, Screening microscope
  • 3 HIVE modules recommended

Small Core Facility Example

  • 1 to 2 rooms
  • up to 5 microscopes
  • replaces 3 image analysis workstations
  • 3 HIVE modules recommended

Medium Core Facility Example

  • 3 to 4 rooms
  • 5 to 10 microscopes
  • replaces 5 image analysis workstations
  • 4-5 HIVE modules recommended (depending on microscopes)

Large Core Facility Example

  • 4 to n rooms
  • 15 microscopes
  • replaces > 5 image analysis workstations
  • 5-6 HIVE modules recommended (depending on microscopes)

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