maXis II LC-QTOF

maXis II™ / maXis II™ ETD

작은 분자에서부터 Megadalton 에 이르는 복합물까지의 다양한 분석

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MaXis plus

최신의 HDC cell 과 50 GBit/sec 디지타이저 기술, 그리고 이에 따른 어플리케이션 패키지와 함께 HR-QTOF 를 놀라운 가격에 구매하세요. 브로셔를 다운받으시려면 여기를 클릭하십시오!

maXis II 는 고분해능 LC-QTOF 시장을 선도합니다. 이 장비는 분석하기 어려운 과제를 해결하기 위해 다양한 어플리케이션과 비교할 수 없는 성능을 갖춘 Q-TOF 로서 새로운 기술의 시대를 열고 있습니다.

 

특화된 다양한 성능 파라미터들이 동시에 충족됩니다.

브루커의 초고분해능 QTOF (UHR) 기술은 accurate-mass LC-MSMS 를 통해 새로운 기준점이 되었습니다. 그리고 이 시스템은, 단일클론 항체 소단위체를 가지고 있는 인택트 프로테인의 연속적인 분석을 위하여 전자-이동 해리 (ETD) 의 가능성을 제안합니다. 

뿐만 아니라, 원 상태의 샘플 또는 항체 약물 결합체를 포함하고 있는 샘플을 분석하기 위해서는 더욱 향상된 성능이 필요합니다. 

Technological Innovations

  • Record-breaking full sensitivity resolution (FSR) of > 80,000
  • Robust ETD capabilities with novel nCI source and Gas Enrichment Apparatus (optional)
  • Native Mass Spectrometry (optional) with enhanced desolvation of super molecular complexes
  • High Definition 5 orders of magnitude dynamic range achieved at UHPLC speeds due to 50 GBit/sec sampling technology-definitive trace analysis from complex, high-background matrices
  • Instant Expertise™ Intelligent self-optimizing MS/MS routines for expert-caliber results first time
  • One shot plug & play acquisition with triple-quadrupole sensitivity ensuring qualitative and quantitative results in one LC run with fastest time-to-success
  • DC gradient collision cell for high sensitivity, fast MS/MS

Applictions maxis II

Antibody Characterization - Intact and Subunit Analysis

Enhanced resolution and mass precision - for highly precise and accurate determinations of the monoisotopic masses of both the Light and Heavy Chains of mAb's on an LC timescale for automated confirmation of product identity and detection of impurities. Superb raw data quality allows for fast and easy detection of modifications (including deamidation) in biotherapeutic characterization without the need for time and cost intensive digestion and peptide mapping of the entire antibody.

 

 

 

 

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Complex Protein Mixture

The maXis II delivers superb dynamic range (5 orders of magnitude) at UPLC speeds enabling analysis of protein mixtures in complex, high-background matrices. For example > 1000 proteoforms resolved in a 35 min run from an undiluted serum sample.

 

  • • Sub-ppm mass accuracy & isotopic accuracy
  • • Isotopic resolution even for proteins > 40Kda
  • • MS/MS available for proteoform ID

 

Further information: Proteomics

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Native Mass Spectrometry (optional)

The High Mass Option combines adjustable Funnel 1 pressure with in-source CID on the maXis II to permit efficient desolvation and ionization of the native sprayed analyte without sacrificing other performance vectors. Thereby enabling easier application of native MS or high mass workflows for the structural investigation of larger proteins and/or protein complexes (including antibody drug conjugates).

 

Further Information: Intact Protein Characterization

Bruker App-Note: LCMS-94

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Robust LC-ETD capabilities

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with novel nCI source and Gas Enrichment Apparatus. Top-down MW measurement plus LC-ETD sequence data to detect and localize post-translational modifications (PTMs) in mAb's faster.

 

Further information: Top-Down Protein Characterization and Intact Protein Characterization

Bruker App-Note: ET-36

Bruker Daltonics services are performed by factory trained and certified engineers. DIN EN ISO 9001:2000 requirements are fulfilled.

 

Available services include:

  • Help desk service for a faster access to our support team, to your service order follow up and for general information
  • Planned maintenance, according to our requirement
  • Telephone support from highly-skilled troubleshooting professionals, to isolate and resolve hard- and software problems
  • Web-based remote instrument service for service diagnosis and applications support
  • Customer on-site repair and maintenance service
  • Spare parts availability typically over night or within a few working days worldwide
  • Compliance services for installation qualification, operational qualification / performance verification
  • Site planning and relocation
  • Advise to improve labs efficiency (consumable, method development & how to run the complete solution)

For Research Use Only. Not for Use in Clinical Diagnostic Procedures.