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EPR Detection of Reactive Oxygen and Nitrogen Species (ROS and RNS)
ROS Detection Cancer
Honokiol (HNK) is a promising anticancer agent derived from the bark of an oriental medicinal plant Magnolia officinalis. It has been concluded that HNK treatment triggered cytoprotective autophagy in prostate cancer cells, which can be exploited to increase anticancer effect of this promising natural agent. A cell-permeable spin probe (CMH) was used to detect ROS by EPR in prostate cancer (PC-3) cells.
ROS Detection Tumor
Nitric Oxide (NO) and Reactive oxygen species (ROS) are endogenous regulators of angiogenesis-related events as endothelial cell proliferation and survival, but NO/ROS defect or unbalance contribute to cancers. A novel photoactive inhibitor called NS1 constitutes a promising tool that modulates NO and redox stresses with great potential to control angiogenesis.
ROS Detection Diabetes
Type-2 diabetes mellitus (T2DM), with over 6 million new cases reported per year, currently represents one of the world’s chief economic and health care challenges. Recent studies place altered mitochondrial oxidative phosphorylation (OxPhos) as an underlying genetic element of insulin resistance.
ROS Detection Alzheimers
Increasing evidence indicates that abnormal Cu2+ binding to Aβ peptides are responsible for the formation of soluble Aβ oligomers and ROS that play essential roles in AD pathogenesis. UV light exposure pronouncedly enhances cytotoxicity of the chelator-treated and -untreated Cu2+ bound Aβ42 aggregates.
ROS Detection Enzymes
The Nox family of enzymes (Nox1 to -5, Duox1 and -2) and mitochondrial electron transport enzymes are among the major sources of cellular reactive oxygen species (ROS), including superoxide radical anion (O2⨪), hydrogen peroxide (H2O2), and related oxidants.
ROS Detection Herbal Medicine
Chinese medicine formula Qing Huo Yi Hao (QHYH) reveals to be a potent antioxidant acting as scavenge of superoxide anions in high glucose-treated endothelial cells.
ROS Detection Ischemic Stroke
Extensive research has identified citotoxicity, oxidative stress, inflammation, and cell death (necrosis and apoptosis) as key contributory pathways underlying lesion progression. See how EPR contributes to politherapy approach to these diverse injury mechanisms
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