The Bio-NMR group, headed by Roland Riek, is part of the Laboratory of Physical Chemistry at the Department of Chemistry and Applied Biosciences of the Swiss Federal Institute of Technology (ETH) Zurich.
Nuclear Magnetic Resonance Spectroscopy (NMR) is one of the principal experimental techniques in structural biology to determine atomic resolution structures and to investigate dynamic features and intermolecular interactions of biological macromolecules. Using NMR as a major tool, the objective of the research in our group is to understand the conformational switches of proteins associated with amyloid diseases and trans-membrane signaling.
The function of each cell and each organism decisively depends on the dynamic interactions between biological macromolecules and on their correct three-dimensional structure. Faulty interaction and incorrectly folded structures eventually lead to diseases and ageing.
The aim of the Institute for Physical Biology at the Heinrich Heine University of Düsseldorf is to understand these interactions and to determine the three-dimensional structure of the protein complexes involved in decisive cellular processes - if possible, in atomic resolution.
They are interested in understanding the structural features of life's key players and to use their insights to identify new therapeutic opportunities to interfere with disease-related processes.
In this respect the Etzkorn Group at the Institute for Physical Biology of the Heinrich Heine University Düsseldorf focuses on the following topics:
Membrane systems in neuronal signalling, NMR method development, Biocatalysis.
The uNMR-NL facility enables non-invasive characterization of molecular systems from the atomic to micrometer range by ultra-high field NMR. The current uNMR-NL high-end 1.2 GHz spectrometer is equipped with state-of-the-art instrumentation for all fields of research needed, providing the highest sensitivity and resolution in the Netherlands.