Multiomics spatial biology imaging

MALDI Imaging enables spatial molecular analysis directly from tissue sections without the need for antibodies, fluorescent labels, or other molecular tags. A single experiment can generate information on thousands of molecules simultaneously while preserving their spatial distribution within the sample.

MALDI Imaging supports the analysis of a wide range of molecular species, including metabolites, lipids, drugs, peptides, and proteins. This versatility makes it suitable for applications ranging from basic research to translational and pharmaceutical studies.

Yes. MALDI Imaging data can be seamlessly integrated with histological and microscopic images, enabling researchers to correlate molecular information with tissue morphology and specific anatomical structures.

Bruker’s imaging platforms are designed for high-throughput data acquisition, enabling large tissue areas to be analyzed at high spatial resolution (5 µm pitch, without oversampling). Systems such as the timsTOF fleX, rapifleX^® or neofleX™ were specifically developed to combine imaging speed with analytical performance.

Because MALDI Imaging is an untargeted and label-free technology, researchers can investigate the spatial distribution of thousands of molecules in a single experiment. This makes it a powerful tool for discovering novel biomarkers and studying disease-related molecular changes directly within tissue.

Platforms such as the timsTOF fleX allow researchers to add a spatial dimension to established omics workflows. This enables direct correlation of proteomics, lipidomics, and metabolomics data with tissue architecture, providing deeper biological insight. SCiLS Ion Image Mapper and REST API deliver the necessary software to combine/overlay multiomics or even multimodal datasets. 

Bruker is one of the few providers offering a complete MALDI Imaging ecosystem from a single source. Our portfolio includes sample preparation solutions, validated consumables, market-leading MALDI Imaging instrumentation, automated workflow software, and advanced data analysis tools. All components are designed to work together seamlessly, eliminating the need for multiple third-party solutions. With proven workflows, dedicated application expertise, and comprehensive hardware and software support, Bruker helps researchers establish robust, reproducible MALDI Imaging workflows and accelerate scientific discovery.