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Bacterial Metabolomics

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Microorganisms have a long-standing tradition as a source of biologically active small molecules – termed “secondary metabolites“. Besides activity-guided isolation, metabolomics based strategies are becoming increasingly successful in revealing additional natural products. These approaches hold great promise for uncovering novel secondary metabolites from bacterial and fungal strains.

Examples for biologically active compounds are novel antibiotics to target resistant pathogens.

Microorganisms are used in industrial scale production of biologically active small molecules, as well as other target compounds like amino acids and vitamins used e.g. for food supplementation. In order to increase the production of the desired product metabolomics is often applied to direct rational strain design based on genetic engineering. This approach often goes in hand with functional genomics studies to unravel gene functions in basic research. In summary metabolomics has become an integral part in microbial research.

Bruker´s LC-MS, GC-MS and NMR based metabolomics solutions perfectly match the requirements for comprehensive metabolic profiling, sample throughput, compound identification, validation and quantification.