Metabolomics aims at a comprehensive qualitative and quantitative analysis of all small molecules present in a cell a tissue or an organism to study the interplay in response to intrinsic and extrinsic factors. Metabolomics recently caught up with complementary efforts to understand the genomes, transcriptomes and proteomes to establish holistic pictures of biological systems.
Metabolomic analysis must accurately determine even the slightest changes of molecular profile related to disease, disease progression, therapeutic intervention, genetic modification or environmental variation.
Disease, drugs, or environmental variation can perturb concentration and fluxes in intermediary metabolic pathways. These responses involve adjustment of intracellular and extra cellular environments in order to maintain homeostasis. Both perturbation and adjustment are expressed as changes in the normal
patterns in cells and biofluids that are characteristic (a "fingerprint") of the nature of the site of the action. These patterns can be evaluated using spectroscopic / spectrometric techniques combined with multivariate statistical methods to gain insight into the molecular response of a biological system.
To determine functions of “unknown” genes in functional genomics studies, Metabolomics has gained increasing attention since changes in small molecule concentrations are closely related to the observed phenotype.
Our systems can be used for a broad variety of targeted and non-targeted metabolomics studies. They are very well equipped to detect, identify, and measure metabolome molecules covering the entire metabolomics chemical space. Thus,
For Research Use Only. Not for use in clinical diagnostic procedures.