Poster Hall Metabolomics

Posterhall Metabolomics and Lipidomics

The research field metabolomics aims at a comprehensive qualitative and quantitative analysis of all small molecules present in a cell, a tissue or even a whole organism. Responding to intrinsic or extrinsic triggers, the entirety of compounds will change. And the goal of studying these responses is to get a more holistic picture to understand e.g. the emergence and progression of diseases.

 

The lipidome can be considered a subset of the metabolome, covering all lipophilic compounds. Many lipids play important roles for example in cell communication and are associated with metabolic diseases. The similarity in the physical properties of lipids, despite their structural diversity demands for dedicated workflow solutions. These are different compared to classical metabolomics approaches. Both applications are supported in MetaboScape and both are facilitated by the additional dimension that is achieved using Trapped Ion Mobility Spectrometry (TIMS).

 

This poster hall shows a unique collection of investigations that leverage Bruker technology, e.g. showing the benefit of CCS values and the PASEF® acquisition mode. We are very thankful to everybody who contributed their research results.

 

And we hope you enjoy reading through this poster hall as much as we enjoyed putting it together.

Poster Hall Metabolomics and Lipidomics

4D-Lipidomics

Poster ASMS 2023: Profiling and quantitation of bile acids in human biofluids by LC-TIMS-MS

Poster ASMS 2023: The Caenorhabditis elegans lipidome blueprint – established using UHPLC-QTOF-MS and UHPLC-IMS-QTOF-MS

Poster ASMS 2023: High-throughput UHPLC-TIMS-based lipidomics: Sub-5 min screening of plasma, cells, stool and tissues

Poster ASMS 2023: Lipid-class specific internal standard normalization of HILIC-MS/MS data embedded into untargeted data processing and interactive exploration

Poster ASMS 2023: 4D Analysis of Lipid Nanoparticles (LNP) using Elute-timsTOF Pro 2 with VIP-HESI Source 

Poster 2023: 4D-Lipidomics™ profiling of cardiolipins on heart tissue from Barth syndrome patients using timsTOF mass spectrometry

Poster IMSC 2022: Novel workflow for improved sensitivity and annotation quality of eicosanoid LC-MS-based analysis

Poster IMSC 2022: Improved sensitivity and higher lipid annotation ID capabilities using a new vacuum insulated heated ESI source

Poster ASMS 2021: Trapped Ion Mobility PASEF Based Lipidomics Highlights Potential Lipid Biomarkers of Covid 19 severity

Poster 2021: HESI 4D-Lipidomics™ on timsTOF Pro 2

Poster 2021: Quality control in 4D-Lipidomics™

Poster 2020: 4D-Lipidomics™ investigation in search of the fountain of youth 

Poster 2020: 4D-Lipidomics™ analysis for the study of peroxisomal inborn errors of metabolism

Poster ASMS 2020: New tools for an advanced 4D-Lipidomics annotation workflow

Poster 2019: High speed untargeted 4D-lipidomics™ LC-MS/MS workflows with Parallel Accumulation Serial Fragmentation (PASEF®)

Poster 2019: CCSPredict: Using a Machine Learning Approach for higher Confidence in Lipid Identification

4D-Metabolomics

 

For Research Use Only. Not for use in clinical diagnostic procedures.