This CryoProbe with integrated cooled preamplifiers for 1H, 13C, 15N and 2H allows considerable progresses in 13C direct detection for biomolecular NMR applications.
The next-generation 15N optimized CryoProbes with cold 15N preamplifiers will now be offered up to 1 GHz. In conjunction with the latest GHz-magnets and novel 15N direct-detect NMR methods, the CryoProbe makes direct 15N detection sensitive and advantageous in very large globular proteins and in IDPs due to the longer relaxation times, high resolution and low chemical shift anisotropy of 15N spectra.