InsightMR for High-Field

High-Field NMR for PAT: Real-Time Reaction Monitoring

High-field Nuclear Magnetic Resonance (NMR) serves as an effective Process Analytical Technology (PAT) tool for real-time monitoring, optimization, and control of chemical and bioprocesses. Ideal for both industrial and academic settings, InsightMR empowers scientists to study, optimize, and control reactions with real time, on-line and in-line NMR monitoring under true process conditions. Combining a robust flow unit with dedicated software, InsightMR enables seamless integration into PAT frameworks.

Gathering insights into the mechanism and kinetics of chemical reactions is now at your fingertips!

• Provides answers to key chemical questions: reaction yield, mechanistic insights and reaction kinetics
• Harness NMR data to make strategic process chemistry decisions, ultimately leading to cost savings.

InsightMR Flow Unit

Design for on-line and in-line reaction monitoring, InsightMR flow unit is a PAT-ready solution that enables comprehensive analysis and confident decision-making directly under actual operating conditions and captures the start of the reaction.

InsightMR for High Field NMR

• Temperature controlled transfer lines: -20 to 120 °C capability
  
• Tested to withstand pressures over 10 bar
• Interchangeable glass tube. Proven robustness - industry tested
• Compatible with all Bruker sample changers
  
• 3- or 5-mm (Room Temperature and Cryo) Probes
• InsightMR 2.0 software.

InsightMR software is a platform designed for the analysis of chemical processes by on-line and in-line NMR. Integrated acquisition control and data processing features enable on-the-fly on-line and in-line acquisition parameter adjustment based on real-time kinetic data.

• Straightforward data acquisition with on-the –fly visualisation of build-up curves. Default experiments provided for both deuterated and non-deuterated solvents
• Rapid and effortless handling of hundreds of stacked spectra
• Supports acquisition, processing and analysis of series of 1Ds (different nuclei), interleaved experiments and multi samples in parallel
• Automatic seamless transfer of spectra to Mnova reaction monitoring Workstation (e.g. phase, baseline and GSD)
• Access to database, prediction, assignment and chemometrics tools
• Results are delivered as kinetic, and waterfall plots ready to report and/or export.

• On-the-fly quantitative build-up curves without the need of tedious calibration steps 
• Structural information for reagents, (bi)products and intermediates 
• Increased selectivity, resolution and sensitivity compared to vibrational spectroscopy
• Used also to calibrate other techniques
• Straightforward installation and operation with minimal learning curve