Adding the 4th dimension
Increases depth of LC-MS/MS workflows
Ion mobility is a powerful extension to mass spectrometry that delivers information about the three dimensional structure of an ion, and increases peak capacity and confidence in compound characterization.
timsTOF was engineered by Bruker experts as an open platform to accelerate the adoption of ion mobility-mass spectrometry analysis across research applications.
The highly unique TIMS design enables unmatched duty cycle (up to 100%), significant improvement in IMS resolution (R>200), unprecedented collisional cross section (CCS) reproducibility and high sensitivity.
With the flip of a switch, augment the peak capacity of your analytical system beyond chromatography and time-of-flight separation. No penalty in analysis time, no penalty in sensitivity.
timsTOF features adjustable ion mobility separation based on Trapped Ion Mobility Spectrometry (TIMS), so you can explore samples in various and meaningful ways. Furthermore, timsTOF uses an open data format (*.tdf) that introduces full transparency, efficiency and flexibility into your data analysis strategy.
timsTOF combines high ion mobility resolution with ultra-high resolution QTOF technology for optimal performance. imeXTM technology further boosts the functionality by making ion mobility resolution an adjustable parameter.
Investigate your sample in imeX survey mode for mobility-resolved full scans, and then extend your workflow with a detailed examination of selected compounds and precise collisional cross sections (CCS). Increase ion mobility resolution up to 200 for unique insights into your samples in imeX ultra mode.
Confident identification of compounds is based on orthogonal qualifiers that are reliably reported with high accuracy. With timsTOF, exact mass measurements (low ppm) are complemented with Bruker’s unique isotopic pattern fidelity (True Isotopic Pattern or TIPTM) and precise collisional cross section determination (<0.5% RSD).
Instrument geometry and the positioning of ion mobility separation prior to quadrupole isolation and fragmentation generate clear fragmentation spectra to further enhance certainty of identifications.
Analyze isomeric compounds
Ion mobility separation is a very powerful approach to separate isobaric or isomeric compounds. Especially in combination with high resolution accurate mass spectrometry, ion mobility separation greatly enhances substance identification and characterization capabilities, and provides an additional physical property of compounds, the CCS values.
High confidence forensic screening
Ion mobility combined with high resolution (HRES) mass spectrometry allows for the identification and characterization of known as well as unknown designer drug analytes and their metabolites.
Characterize plant metabolites and secondary metabolites
„We are already using ion mobility in our lab, but with the much higher ion mobility resolution that timsTOF provides now, there is a lot of room for different applications based on this technology.“
For Research Use Only. Not for use in clinical diagnostic procedures.