SLAS2025

• Meet us at Booth 2027: We're looking forward to meeting you in front of our biosensors, Beacon^® and mass spec-based solutions that will be on display at our booth. Take the chance to discuss with our experts how our solutions can help you in current and future projects.
• Exhibitor tutorials: Attend our tutorial sessions hosted by Bruker's expert team to discover the latest on Bruker’s Biosensors and antibody screening solutions.

A pipeline to success: Biosensor Tools Enable Next Generation Therapeutic Molecules

Location: Room 24C

Lab automation technologies are transforming biologics development by streamlining the selection and optimization of candidates. However, the complexity of biologics—often involving intricate structures and binding interactions—presents challenges in optimizing pharmacokinetics, efficacy, and safety.

This presentation highlights three advanced automated biophysical tools: high-throughput, multiplexing Surface Plasmon Resonance (SPR) for rapid candidate identification and detailed lead development, switchSENSE^® for analyzing avidity effects and multispecific binders, and single-cell Interaction Cytometry for real-time kinetic measurements directly on cells to assess native binding properties.

These tools offer comprehensive profiling to accelerate biologics development by identifying lead candidates with optimal biophysical characteristics and are also applicable to other therapeutic modalities like small molecules.

Advancing Therapeutic Antibody Discovery: High-Throughput Single B Cell Screening for Challenging Targets and ADCs on the Beacon^® Platform

Location: Room 24C

Bruker Cellular Analysis presents innovative solutions for traditional antibody and heavy chain-only antibody (HCAb) discovery, specifically for challenging targets and diverse therapeutic applications like antibody drug conjugates (ADCs), using the Beacon^® Optofluidic Platform. 

The Beacon^® Platform enables rapid, specific antibody identification and offers modular kits that integrate seamlessly with immunization workflows, supporting each stage from initial immunization to final antibody selection. By reducing development time and enhancing discovery success, this end-to-end approach optimizes antibody discovery campaigns.

The session will showcase how Beacon’s microfluidic technology isolates and analyzes single B cells, allowing researchers to efficiently identify rare, high-quality therapeutic antibodies, including a case study of how Twist has developed a novel approach to screening for antibody internalization on the Beacon platform to accelerate the development of ADCs. 

Networking Symposium

Location: The Cafe, Foundry & Lux, South San Francisco, CA

Continue the discussions from SLAS and join us for an exclusive cocktail hour with guest speakers presenting applications of emerging biophysical methods in drug discovery. Registration is free but mandatory, find more information, confirmed speakers, and the registration form on the event website.

As you are certainly aware, special compliance regulations apply to public officials* and healthcare professionals** with regard to the event we are planning. If you accept our invitation, we will therefore assume that you will observe the compliance regulations that apply to you and that you have the necessary employer approval.

*Government Official means according the Bruker policies any of the following: any officer, employee or representative of a government (national, regional or local) entity, or any public agency, public authority, department or instrumentality thereof, regardless of their rank or title (e.g. a regulatory official or government inspector); any person working for or advising a government-owned or government-controlled enterprise (e.g. a professor at a government-owned university, or a purchaser at a government-owned hospital); any person working for or advising a national or international non-governmental organization (e.g. an employee of the Red Cross or The World Bank); any person performing a public function or providing a public service, even if that person works for a non-governmental institution (e.g. private security personnel working in public functions); any person hired to review or accept bids for a government agency; any person with the responsibility to allocate or expend government funds; any person in a public law function, civil servant, judge or military personnel; any person acting for a political party, including party officials, candidates or individuals holding a position in a political party office; members of royal families; or immediate family members of any of the persons listed above. An immediate family member is a grandparent, parent, spouse, significant other, child, or sibling.

**A Healthcare Professional (HCP) is in accordance with the Bruker policies any physician, dentist, nurse, pharmacist or other individual who may prescribe, administer, purchase, dispense, recommend, or supply medical products or treatments or pharmaceutical products. In many cases, Bruker interacts with HCPs who work for state-owned hospitals (e.g. as medical scientists). These individuals will be classified as both HCPs and Government Officials.