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On-Demand Session: Uncovering Transcription Condensate Organization With Single Molecule Resolution

Find out what single-molecule imaging can reveal about transcription condensate organization 

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Jan Spile, Ph.D., Assistant Professor, Department of Physics, University of Illinois (January 17, 2024)

       PRESENTATION HIGHLIGHTS:

  • [00:00:00] Background on Transcription
  • [00:06:05] How Can Enhancers Co-Regulate Promoters?
  • [00:16:58] Anchoring Condensates to Underlying Structures
  • [00:22:08] Imaging Epigenetic Information with Super-Resolution Microscopy
  • [00:33:43] Super-Resolution Cluster Analysis
  • [00:42:46] Single-Molecule Kinetics
  • [00:49:05] Conclusion and Acknowledgements
Watch Now | 10 Minutes

Q&A

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       PRESENTATION HIGHLIGHTS:

  • [00:00:00] Would having multiple regulatory elements in one common site indicate the presence of multiple genes? What does it mean for the transcription?
  • [00:01:37] How did you identify the condensates?
  • [00:03:37] Is the mechanism different from stem cell to cancer cell? 
  • [00:04:00] Could you expand on the challenges and solutions in regards to multicolor Imaging?
  • [00:07:18] In terms of translation research, can you comment on the epigenetic agents for cancer cell for treatment?

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