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Fluorescence Microscopy Library

Research Highlight: 
Rengasayee “Sai” Veeraraghavan, Ph.D.

Associate Professor, Department of Biomedical Engineering
The Ohio State University

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Nanoscale Imaging of Cell-to-Cell Communication in the Heart with Super-Resolution Microscopy

This research highlight features Dr. Rengasayee “Sai” Veeraraghavan, Associate Professor in the Department of Biomedical Engineering at The Ohio State University. Sai discusses his use of the Vutara single-molecule localization based super-resolution microscope to image nanoscale intercellular signaling within the heart. He also discusses potential applications of his STORM imaging techniques in cancer research.

"One of the things we love about the Vutara is the fact that it's in a wide field configuration, and therefore it is usable for our problem space. Cardiac muscle tissue, even in five-micron sections, is so optically dense that if you're doing TIRF or sub-critical angle illumination, you simply do not get enough photons into the sample to do the job. And I know this from painful experience, having tried out those types of systems. The biplane and the widefield configuration of Vutara are absolutely mission critical for what we do."

Rengasayee “Sai” Veeraraghavan, Ph.D., Associate Professor, Department of Biomedical Engineering
The Ohio State University

Summary

ABOUT THE RESEARCHER:

Dr. Rengasayee “Sai” Veeraraghavan is an Associate Professor in the Department of Biomedical Engineering at The Ohio State University.

FIELD OF STUDY:

Dr. Veeraraghavan's research focuses on electrical signaling-based cell-to-cell communication in cardiac cells, a critical component of heart health.