The In Situ FT-IR Reaction Monitoring Solution

The ALPHA II INSITU-ATR enables FT-IR measurements directly in the reaction medium. It supports reaction monitoring without sampling or transfer, providing spectral information from the chemical process while it is running.

• Direct measurement.
• Continuous reaction data.
• No sampling step.
• Real lab conditions.

Reaction development depends on information that reflects the chemical system under actual experimental conditions. Offline analysis often requires sampling, transfer, dilution, cooling, or exposure to air. Each of these steps can change the composition before measurement, especially in systems with unstable intermediates, temperature-sensitive equilibria, or phase-dependent reaction behavior.

The ALPHA II INSITU-ATR allows infrared spectra to be recorded directly from the reaction medium. Instead of analyzing a removed sample, the reaction is monitored in place. This provides access to spectral changes as they occur and supports a more complete understanding of reactant consumption, product formation, intermediate species, and endpoint behavior.

Take a look at our application note, demonstrating the tracking of a saponification reaction.

The INSITU-ATR module extends the ALPHA II platform for reaction monitoring applications while preserving the instrument concept of application-specific configurations. The module provides direct optical access to the reaction medium and can be used for workflows where laboratory-scale synthesis, method development, or process understanding require time-resolved infrared data.

Furthermore, exchanging the front module with one of the other ALPHA II QuickSnap modules makes the system suitable for laboratories that need compact FT-IR instrumentation for both routine analytical work and dedicated reaction studies, without separating reaction monitoring from the established ALPHA II environment.

Typical Application Areas

• Monitoring of organic and inorganic reactions.
• Reaction endpoint determination.
• Observation of reactant consumption and product formation.
• Investigation of intermediates and side reactions.
• Kinetic studies and reaction profile comparison.
• Optimization of synthesis parameters.
• Support of scale-up and process transfer studies.