NMR is nowadays an important tool for the monitoring of chemical reactions in academic and industrial settings. Utilization of the inherent structural and quantitative information delivered via NMR spectroscopy provides detailed mechanistic insights and increased process understanding.
During the past few years, various approaches to reaction monitoring by NMR have shown that online monitoring is the most effective method to obtain accurate and consistent kinetic data. This approach is far superior to other, more traditional, methods (e.g. holding a sample static within the magnet or periodically removing, inverting and returning the NMR tube).
After being Introduced in 2017 the InsightMR flow tube has been widely used for online reaction monitoring. This accessory can be easily applied to a standard spectrometer system when required for an online measurement campaign: the spectrometer can then be quickly returned to its normal configuration.
Based on customer feedback and ideas from other sources, the insightMR has been further developed, for example so that it can readily cope with risk of clogging and so that different diameter NMR tubes can be used. The details of this enhanced product, the InsightMR 2.0, will be described during this seminar.
Thursday September 16, 2021
All personnel, from both industrial and academic groups, who are associated with the field of synthetic organic chemistry and process development: Process chemists, Analytical chemists, Synthetic organic chemists, Chemical engineers, Chemistry and pharmaceutical sciences students, Regulatory specialists.
Dr. Matteo Pennestri
Product Manager, Pharmaceutical Business Unit, Bruker
Royal Society University Research Fellow
Centre for Sustainable and Circular Technologies