A study published in Cell Press highlighted fundamental discoveries in proteomics concerning the nature of autophagy. A pro-autophagosomal component formed by the merging of components that include FIP200 and ATG16L1 was termed hybrid pre-autophagosomal structure (HyPAS) and the integral role of SNARE STX17 to HyPAS formation was described.
Importantly, this research elucidated the means by which SARS-CoV-2 viral infection inhibits pro-phagophore formation by nsp6 targeting of HyPAS apparatus. This research was carried out using a range of techniques, including Bruker PepSep™ separation columns, an indispensable, but often-overlooked tool in the field of proteomics.
Like these pioneers, you should not be held back from your proteomics breakthroughs due to column performance. Bruker products enabled these researchers to achieve illuminating results. The PepSep™ columns used in this study have become an indispensable tool for proteomic analysis.
I made my own columns for 15 years until I started using PepSep™. They blew my columns out of the water in terms of performance so switching to them was a no brainer.
For Research Use Only. Not for use in clinical diagnostic procedures.