X-omics Festival 2026

We are delighted to welcome you to the X‑omics Festival 2026 co-organized by Institute for Chemical Neuroscience iCNS on April 13 in Nijmegen, The Netherlands.

Throughout the event, you’ll have the opportunity to explore cutting‑edge technologies, gain new perspectives on multi‑omics workflows, and connect with researchers driving innovation in biological and biomedical sciences.

The Bruker team looks forward to welcoming you at our booth to share insights into our high‑resolution mass spectrometry solutions and to discuss how integrated omics approaches can support your research.

We also invite you to join the Bruker-sponsored talk, featuring a real‑world multi‑omics case study that showcases parallel HRMS workflows in C. elegans.

Please note: Registration for the X‑omics Festival is managed by the conference organizers.

To attend the Bruker-sponsored talk, please register directly via the official conference website.

Caenorhabditis elegans is a well-established model for ageing research. Mutation in the gene daf-2 leads to reduced insulin/IGF-1 signaling known to extend lifespan in the nematode. While many studies profiled single omics layers in order to understand longevity in this mutant, coordinated multi-omics integration remains challenging. Here, we present a combined high-resolution mass spectrometry based (HRMS) workflow enabling integrated proteomics, metabolomics, and lipidomics from the same biological material. Wildtype N2 and long-lived daf-2(e1370) worms were cultured under identical conditions (n=5 per strain). Biphasic extraction enabled parallel acquisition of HILIC-based metabolomics from the aqueous layer, lipidomics from the organic layer, and proteomics from the protein pellet using different timsTOF platforms, followed by cross-omics integration using network- and factor-based approaches. Integrated analyses revealed coherent metabolic remodeling in daf-2 mutants, including triglyceride accumulation, phospholipid remodeling, elevated β-oxidation metabolites, and increased TCA cycle intermediates, consistent with enhanced mitochondrial activity and stress resilience. Proteomics supported these findings, showing upregulation of fatty acid metabolism, oxidative stress response, and innate immunity proteins, alongside reduced vitellogenins. Cross-omics concordance highlights insulin/IGF-1 signaling as a central regulatory axis and demonstrates that harmonized multi-omics integration robustly captures canonical longevity biology beyond single-omics resolution.

Please note: Registration for the X‑omics Festival is managed by the conference organizers.

To attend the Bruker-sponsored talk, please register directly via the official conference website.