Swiss NMR Users Meeting
Bruker Swiss NMR Users Meeting
We are so excited to be hosting our Swiss NMR Users Meeting in person at our site in Faellanden Switzerland. We will have talks from our Bruker experts, guest speakers, and tours of our manufacturing and production facilities.
We welcome our guests from 9:00 AM on with coffee and a light breakfast and our first talk will begin at 9:45. We will finish up the day with some workshops and facility tours around 17:00.
We do have limited parking on-site and there is bus service from Schwerzenbach train station.
We looking forward to welcoming you in Faellanden!
Please see our full agenda below.
Agenda
| Zeit: | Programm: | Referentin/Referent: |
|---|---|---|
| ab 09:00 – 09:45 | BEGRÜSSUNGSKAFFEE | |
| Vorträge: | ||
| 09:45 – 09:55 | Begrüssung | Falko Busse |
| 09:55 – 10:15 | Ultra-High Field NMR Magnet News & Updates | Daniel Baumann |
| 10:15 – 10:35 | Fourier 80 – News about features and applications | Sandra Loss |
| 10:35 – 11:00 | NMR Platform @ EPFL: Maintaining 20 Spectrometers and Managing 400 Academic Users | Aurélien Bornet |
| 11:00 – 11:30 | PAUSE | |
| 11:30 – 11:50 | News & Updates on Liquid-state NMR Probes | Rainer Kümmerle |
| 11:50 – 12:10 | News & Updates on Solid-State NMR | Barbara Perrone |
| 12:10 – 12:20 | Services & Support Updates | Frank Schumann |
| 12:20 – 12:40 | NMR Software and Artificial Intelligence | Bjoern Heitmann |
| 12:40 – 14:00 | MITTAGESSEN | |
| 14:00 – 14:45 | Workshop Runde 1 | |
| A) | Pureshift: Broadband Homonuclear Decoupling | Pinelopi Moutzouri |
| B) | Protein NMR: concepts and practice with BioTop | Robert Schneider |
| C) | Demonstration of the Automation Workflow with MAS Shuttles | Barbara Perrone |
| D) | Firmenrundgang 1 | |
| 15:00 – 15:45 | Workshop Runde 2 | |
| E) | Optimizing Shaped Pulses for Improved Quality of NMR Spectra | Maksim Mayzel |
| F) | When Ambient is Not Good Enough: Tips & Tricks for VT NMR | Aitor Moreno |
| G) | TBD | TBD |
| H) | Firmenrundgang 2 | |
| ab 15:45 | Diskussion mit Bruker Spezialisten bei Bedarf Firmenrundgang 3 |
Abstracts
NMR Platform @ EPFL: Maintaining 20 Spectrometers and Managing 400 Academic Users
Aurélien Bornet, Collaborateur scientifique chez Ecole polytechnique fédérale de Lausanne
The NMR Platform of the EPFL chemistry department (ISIC) manages all the NMR spectrometers of the campus with a total of 24 NMR spectrometers from 20 to 900 MHz, serving 400 academic users (50 research groups) actives in diverse scientific fields, including organic synthesis, life sciences or material sciences, operating with different methodologies, requirements, and priorities.
To accommodate this broad community, effective compromises are made while organizing the platform. This presentation will highlight the platform's structure, recent and futures challenges including helium and energy restrictions, open access solid-state NMR development, and implementation of efficient data management.
Pureshift: Broadband Homonuclear Decoupling
Pinelopi Moutzouri, Ph.D.
PureShift NMR describes the suite of experiments that increase spectral resolution by removing the effects of homonuclear J-coupling. In this workshop, we will cover the theoretical and practical aspects of such experiments as well as experimental setups. We will focus on classic one-dimensional pureshift experiments and their implementation in other types of experiments such as HSQC, selective TOCSY and DOSY.
Protein NMR: Concepts and Practice with BioTop
Robert Schneider, Ph.D.
This workshop will present some basic concepts in modern protein NMR, introduce experiment types that can be used dependent on protein size, and explain how to obtain protein resonance assignments and information on dynamics. In a short practical part, the Bruker BioTop tool for quick and simple setup, acquisition, and processing of protein NMR experiments will be presented. The workshop is directed at users familiar with NMR in general who wish to learn more about its application to isotope-labeled proteins.
Automation Workflow with MAS Shuttles
Barbara Perrone, Ph.D.
With the recent introduction of Bruker MAS iProbes and MAS shuttle experiments requiring magic angle spinning can be setup in full automation. The easy setup of a few representative experiments and their acquisition will be shown live at the spectrometer.
Optimizing Shaped Pulses for Improved Quality of NMR Spectra
Maksim Mayzel, Ph.D.
During the workshop, we will explore diverse applications of shaped pulses in liquid-state NMR. These applications range from small organic molecules to bio-NMR, from selective to broadband excitation and inversion, and from multiple solvent suppression to broadband decoupling. We will demonstrate how optimizing shaped pulses can enhance sensitivity, reduce artifacts, and ultimately improve the quality of spectra. We will learn how to use Topspin tools such as ShapeTool, NMRSim, and specifically, WaveMaker in order to create and analyze selective pulses.
When Ambient is Not Good Enough: Tips & Tricks for VT NMR
Aitor Moreno, Ph.D.
With variable temperature (VT) NMR experiments it is possible to e.g. investigate molecular dynamics, optimize the solubility of compounds, improve chemical and spectral stability, and monitor chemical reactions at the appropriate temperature. After an introduction of different applications of VT NMR, the required components such as NMR probes and cooling devices are discussed. In addition, software tools, interfaces, and AU scripts for performing VT NMR are presented. Finally, tips and tricks for sample and instrument preparation, as well as necessary calibration procedures for optimal VT NMR, are discussed.