Spacer Fidelity Assessments of Guide RNA by Top-Down Mass Spectrometry

This on-demand presentation explores how top-down mass spectrometry (MS/MS) provides direct and quantitative assessments of highly modified CRISPR guide RNAs (gRNAs), ensuring their accuracy and safety for therapeutic applications.

Discover:

• The role of gRNA spacer fidelity in CRISPR-based gene editing
• How MS/MS analyzes gRNA spacer characterization and identifies impurities
• Automated software tools for accurate gRNA sequencing and quantification
• De novo sequencing strategies to decipher highly dissimilar spacer impurities

This presentation is for you if:

• You are involved in the development of CRISPR-based biotherapeutics
• You need to ensure the quality and safety of gRNA used in your research    
• You are interested in cutting-edge technologies for gRNA analysis

Don't miss this opportunity to learn how top-down MS/MS can revolutionize your CRISPR research and development.

By the end of this presentation, you will have:

• A deeper understanding of gRNA spacer characterization by MS/MS
• The knowledge to analyze gRNA impurities and ensure their negligible levels
• Access to powerful software tools for automated gRNA analysis