DISCOVER small molecule binding: Immunoregulatory action of the metabolite itaconate

In this episode of the Bruker Biosensors DISCOVER MOLECULAR INTERACTIONS webinar series Dr. Tomas Paulenda is presenting his data on how metabolites can modulate activation of macrophages and other immune cells. You will learn more about immunometabolic regulatory pathways as well as biophysical characterizations of small-molecule - protein interactions.

This webinar is part of the webinar series DISCOVER MOLECULAR INTERACTIONS by Bruker Biosensors.

In this episode, we welcome Tomas Paulenda from the Washington University School of Medicine in St. Louis, USA as our guest speaker. Tomas is investigating the immunoregulatory effects of small metabolites. He studies how metabolites can modulate activation of macrophage and other immune cells.

In the presented work he identified the molecular mechanism of how itaconate boosts type I interferon signaling and blocks inflammasome activation and linked it to non-covalent interactions between itaconate and Peroxiredoxin 5. You will learn more about immunometabolic regulatory pathways as well as biophysical characterizations of small-molecule – protein interactions.