The Covid19-NMR consortium was initiated at the Goethe University in Frankfurt in March 2020, and has since quickly grown into an international consortium.
Today, scientists from all over the world are collaborating in a unique effort to investigate SARS-CoV-2 using NMR spectroscopy, based on open science principles. We interviewed them to find out about this new approach in science and get to know the latest findings in this interesting approach to tackle this topic together to find medication faster than usual by sharing research findings.
*Research use only
Please find below the latest information video about the Covid19 international project
University of Hannover, Chemistry Departement Hannover, Germany
Using NMR to understand Covid-19 at the molecular level
At Biomolekulares Wirkstoffzentrum (BMWZ), Prof. Dr. Teresa Carlomagno and her group use solid state nuclear magnetic resonance (NMR) to address the structure of RNAs and understand interactions between structured and unstructured molecules and how this effects druggability. Within the COVID-19 NMR Consortium, she is working to understand the how SARS-CoV-2 virus proteins and RNA interact to block the production of proteins in the host cell.
Goethe-University Frankfurt am Main, Germany
Uncovering the inspiration behind the Covid-19 NMR consortium
Prof. Dr. Harald Schwalbe is based at the Goethe University Frankfurt and is an expert in nuclear magnetic resonance (NMR)-based structural biology of RNA, proteins and their complexes. He set up
the Covid-19 NMR Consortium at the start of the pandemic, an international group that now has more than 50 research partners in 70 countries worldwide.
Max-Planck Institute, German Center for Neurodegenerative Diseases, Göttingen, Germany
Covid-19 NMR International Project
Prof. Dr. Markus Zweckstetter is a nuclear magnetic resonance (NMR) spectroscopist who uses NMR to study the most challenging molecules in biology including large macromolecular complexes, membrane proteins, and biomolecular condensates.
SIGNALS GmbH & Co. KG, Frankfurt, Germany
Data management improvements for NMR research
Dr. Carolin Hacker works at SIGNALS, Goethe University, which was founded to promote the digitalization of research and scientific workflows. Dr. Hacker’s expertise lie in nuclear magnetic resonance (NMR) data set management and her team oversees a single central data hub where all the scientific data for the Covid-19 NMR Consortium is stored.
Massachusetts Institute of Technology (MIT), Cambridge, USA
The power of NMR
Professor Mei Hong, Professor of Chemistry at the Massachusetts Institute of Technology, speaks about the potential of high-resolution solid-state nuclear magnetic resonance (NMR) spectroscopy to help resolve the challenges faced by the world’s healthcare industry.
Center for Cooperative Research in Biosciences (CIC bioGUNE), Derio, Bizkaia, Spain
Using NMR to understand the role of glycans in COVID-19
At CIC bioGUNE, Prof. Dr. Jesús Jiménez-Barbero and his group use nuclear magnetic resonance (NMR) to research the role of glycans in molecular recognition relating to pathological events and infectious diseases. Within the COVID-19 NMR Consortium, they are working to understand the receptor binding domain of the spike glycoprotein as the first interacting point of the virus.
University of Florence (CERM), Italy
Consortium demonstrates the power of collaboration
Researchers at the University of Florence in Italy were excited about the opportunities and responsibilities that would come with working with the world’s largest NMR instrument. It went on to produce boundary-pushing results that would help solve one of the thorniest bimolecular scientific challenges to date
Biological Magnetic Resonance Data Bank (BMRB), Madison, Wisconsin, USA
Furthering NMR research through data
The Biological Magnetic Resonance Data Bank (BMRB) aims to empower scientists in their analysis of the structure, dynamics, and chemistry of biological systems and to support further development in biomolecular NMR spectroscopy.
Goethe-University Frankfurt am Main, Germany
Bringing expertise in RNA-protein interactions
Dr. Andreas Schlundt and his group are seeking to understand how ribonucleic acid (RNA) coronavirus protein complexes are structured. They are then using this information to understand if the sequence has a clear impact on ‘drugability’.
Wallenberg Academy Fellows, Stockholm, Sweden
NMR reveals how changes in RNA form deliver viral function
Dr. Petzold leads a group that uses nuclear magnetic resonance (NMR) spectroscopy to establish the structure and functionality of ribonucleic acid (RNA) which makes up the genetic material in certain human pathogens, which is highly relevant to investigating SARS-CoV-2, an RNA virus.
Weizmann Institute of Science, Rehovot, Israel
NMR: At the intersection between physics, chemistry and biology
At the Weizmann Institute of Science, Prof. Lucio Frydman’s main focus is using nuclear magnetic resonance (NMR) to investigate the structure of matter and of molecules. Translating this into COVID-19 research, he and his team are developing new tools to help better understand the structure of the RNA of the virus and the binding ability of drugs.
Universidad Católica de Valencia, Spain
Using nuclear magnetic resonance spectroscopy to help eliminate SARS-CoV-2
Professor Jose Gallego is a research professor at the Universidad Católica de Valencia, in Spain and is currently working within the Covid-19 NMR Consortium to investigate the potential of anti-viral drugs that act by binding to RNA structures in human cells.
Department of Pharmacy, University of Patras, Greece
COVID-19 NMR International Project
Prof. Dr. Georgios Spyroulias works on the Covid-19 NMR consortium project, using nuclear magnetic resonance (NMR) spectroscopy to discover how viral proteins react with host proteins
Institute of Structural Biology, Grenoble, France
Fast NMR exposes machinery of tricky viral proteins
Most proteins – including the all-too-familiar spike protein on SARS-CoV-2 – adopt a functional shape once in situ, known as a three-dimensional fold. NMR spectroscopy enables scientists to study the behaviour of these highly dynamic proteins right down to atomic-level resolution.