Enhancing Biotherapeutic Characterization With MALDI Mass Spectrometry

Biotherapeutics such as monoclonal antibodies, fusion proteins, peptides and cytokines are increasingly complex, creating challenges for rapid and accurate quality characterization. Traditional liquid chromatography methods, such as size exclusion chromatography and hydrophobic interaction chromatography, often struggle with electrospray ionization mass spectrometry (MS) compatibility, slowing impurity identification. 

This webinar introduces a refined matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) MS workflow that streamlines analysis, enables high-throughput screening and integrates with existing development pipelines. Attendees will gain insights into approaches that address structural complexity, enhance analytical efficiency and support faster decision-making in biotherapeutic development.

Key Learning Objectives:

• Learn about the development of cutting-edge biotherapeutic characterization methods using MALDI-MS
• Discover an automated impurity identification workflow, suitable for different modalities and based on MALDI
• Explore methodologies which analyze therapeutic polyethylene glycol linked proteins
• Assess the development of cell-based membrane permeability assay using MALDI-MS