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Pharma & Biopharma

Clinical Research

Pushing the frontiers in clinical research for better health and care

Ultra trace element analysis

Metals play a crucial role for cellular and subcellular functions. These trace elements confer unique reactivities to their respective enzymes. In addition, it is well known that a number of toxic metals can inhibit enzyme functions, which leads to serious health issues.

Trace elements are increasingly used as dietary supplements in the prevention of widespread diseases and as clinically effective adjuvant therapeutics and have become a popular research area in clinical research.

Chemotherapeutic metallodrugs based on platinum or gold play a crucial role in cancer therapy and contrast agents containing Gd are routinely used for MRI examination.

All trace metals even at lowest levels can be easily quantified in all tissues and body fluids by total reflection X-ray fluorescence (TXRF) spectrometer S4 T-STAR.

Elemental imaging

The M4 Tornado micro-XRF spectrometer offers extremely sensitive spatially resolved elemental distribution analysis from Na to Am, while the M4 TORNADOPLUS further extends the element range to C. Both offer detection limits down to ppm, particularly for transition metals. The high-speed, "on-the-fly" mapping, with flexible analysis conditions, makes these spectrometers able to quickly measure high detail, high quality spectral images. One of the major benefits is that no sample preparation is required and that samples can be measured in atmospheric conditions or under Helium atmosphere to preserve organic tissue.
The M4 TORNADO and M4 TORNADOPLUS are suited for research purposes as pre-screening device on large areas to allocate sections of interest where more complex methods like LA-ICP-MS shall be applied.
 

Metabolic Profiling

Completely standardized and fully automated nuclear magnetic resonance (NMR) metabolic profiling platform is the ideal and unique technology of choice for high-performance human body fluid analysis enabling effective clinical metabolomics research and related assay development (on Research Use Only Level)
 

For Research Use Only. Not for Use in Clinical Diagnostic Procedures.

Applications

NMR-MS Based Metabolic Phenotyping Indicated SARS-CoV-2 Infection Affects Multiple Organ Systems

NMR-MS Based Metabolic Phenotyping Indicated SARS-CoV-2 Infection Affects Multiple Organ Systems

Metabolic phenotyping using nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS) has been applied to the characterization of the metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma.

1H-NMR urinary based metabolomics identifies Novel biomarkers of acute kidney injury

In conclusion, this study shows that NMR spectroscopy yields high diagnostic accuracy for AKI in paediatric patients

Identifying Metabolic Variation in Clinical Samples using NMR (For Research Use Only)

“Our results show that day-to-day reliability is highly variable between metabolites in both serum and urine, while lipoprotein subfractions possess high reliability.”
Characterizing New Oncology Drugs with NMR

Characterizing New Oncology Drugs with NMR

Using NMR spectroscopy, this latest research identified the structural modifications to baicalein that provide significant anti-angiogenic and anticancer effects without associated toxicity. In particular, compound 42 with a piperazine acetamide group added at position 6 was shown to represent a novel potential compound for further evaluation as a cancer therapy.

Plasma Metabolomics in H1N1 Influenza Pneumonia Diagnosis

Biomarkers may enable early diagnosis and prognosis, as well as help determine response to treatment. One approach for identifying disease biomarkers is metabolomic profiling.

For Research Use Only. Not for Use in Clinical Diagnostic Procedures.