MALDI Content Collection
Systems that perform for all areas of MALDI experimentation
Overview
MALDI Imaging
You have landed where spatial biology meets mass spectrometry. Explore the capabilities of MALDI Imaging and our workflow offerings that go from discovery to translation.
- Discover how to reveal greater insight and regional heterogeneity for your disease-based research questions with our spatial biology solutions. Broad multiomics coverage and multimodal data integration make mass spectrometry the newest tool for spatial biology.
- Explore MALDI Guided SpatialOMx® for untargeted discovery for the most complete molecular accessibility with contextualized spatial information to provide important clues into intercellular communications networks.
- Targeted imaging for drug discovery brings value to pharma and biopharma workflows.
- Utilize MALDI-2 for maximum sensitivity and dimensionality with trapped ion mobility spectrometry (TIMS).
Characterization of Biologics
MALDI systems have numerous advantages when applied to a wide range of biologics characterization workflows:
- Protein characterization on different levels including intact mass measurements and MALDI top-down sequencing for sequence verification, PTM localization, confirmation of the termini status, sequence deletions, preparation artefacts, and other structural features
- High-sequence coverage using next-generation top-down sequencing with full advantages of TIMS on timsTOF fleX
- Rapid automated analysis of wide range of biologics with setup time of less than a minute and run time of less than 4 minutes for a MALDI plate 384-format on a neofleX
- Rapid mass measurement and sequence confirmation by MS /MS of DNA and RNA oligonucleotides
- Profiling of glycans and structure confirmation by MS/MS
- Comprehensive lipid nanoparticle (LNP) component analysis of all four typical components and detailed characterization of the PEGylated lipid component
Spatial Biology Solutions
Gain more insight per pixel in your multiomics research. Molecular coverage for metabolites and lipids, targeted proteins, N-linked glycans, and more enable ground-breaking research in key disease-based research.
- MSI 30 - MALDI HiPLEX-IHC
- MSI 40 - The neofleX Imaging Profiler: MALDI Imaging on new benchtop axial MALDI-TOF mass spectrometer
- MSI 27 - microGRID ebook
- MSI 37 - Advancing data analysis for spatial metabolomics in 3D cell cultures
- TN 58 - Maximize spatial biology insights with 5 μm MALDI Imaging using microGRID
- TN 59 - SCiLS™ Scope: a new viewing experience for spatial omics via a sharable platform
- MSI 28 - QuPath Integration into SCiLS™ Lab
- MSI 38 - Enhancing analytical depth and throughput in cancer research using IR Guided MALDI Imaging
- MSI 35 - Improving MALDI Imaging Throughput by IR Laser Imaging
Confidence with SpatialOMx®
Bring the depth of 4D-omics to complement the spatial information from MALDI Imaging. Harness the full dual-source power of the timsTOF fleX.
- MSI 41 - Spatial and cell-type specific lipid analysis for in situ assessment of intratumor heterogeneity
- LCMS 166 - MALDI Guided SpatialOMx® uncovers proteomic profiles in tumor subpopulations of breast cancer
- Brochure timsTOF fleX - MALDI Guided SpatialOMx®
- TN 55 - SpatialOMx® lipid analysis of rat brain
Targeted imaging for drug discovery
Targeted MALDI imaging offers label-free, high-resolution molecular specificity and distribution mapping.
Webinar
Protein characterization and MALDI-TDS
- LCMS 237 - In-Depth Protein Sequence Verification by TIMS-enabled MALDI Top-Down Sequencing using OmniScape software
- LCMS 200 - Complete characterization of a 15 kDa nanobody by TIMS-enabled Next-Generation MALDI Top-Down Sequencing
- LCMS 186 - Next-generation MALDI top-down sequencing of protein biotherapeutics – expanding the scope of timsTOF technology
- MT 142 - A Novel Top-Down Protein Sequencing Workflow Employing neofleX Benchtop MALDI-TOF/TOF and OmniScape Software
- PN 59 - Structural study of a PEGylated therapeutic protein by MALDI-ISD and ESI-QTOF
- MT 132 - Recombinant SARS-CoV-2 Receptor Binding Domain: Comprehensive Top-Down Sequence Confirmation, Curation and O-Glycosylation Site Determination
Drug discovery HTS/HTE
- PN 42 - Ultra High Throughput Drug Discovery Screening by MALDI-TOF Mass Spectrometry powered by Simultaneous 1536 well Pipetting
- PN 61 - Novel MALDI-TOF MS Workflow for Ultrahigh-Throughput Screening of Different Analytes at Each Position on a Plate
- MT 122 - Label-free compound profiling in K562 leukemia cells by MALDI-TOF mass spectrometry using heme B as response marker
- MT 123 - Label-free profiling of fatty acid synthase inhibitors using a mechanistic cell-based MALDI-TOF mass spectrometry cell assay
- MT 124 - Profiling mammalian cell differentiation by MALDI-TOF MS: Developing a highly reproducible and robust sample preparation workflow
- MT 125 - Kinase inhibition screening by label-free mass spectrometry employing the MALDI PharmaPulse HTS solution
- MT 129 - Label-free drug uptake analysis of whole cells by MALDI-TOF mass spectrometry using the transport protein OATP2B1 as an example
- MT 130 - High-throughput MALDI-MS based read-out of high-density droplet microarrays facilitating next generation on-chip drug discovery
- MT 141 - Cell-free MALDI-TOF assay providing information-rich amyloid-β peptide profiles as a new tool in Alzheimer research
- LCMS 182 - High-throughput experimentation reaction monitoring and analysis of chemistry synthesis products with ultrahigh-throughput 4D timsTOF fleX MALDI-2 technology
- LCMS 216 - Next-Level Performance in Label-Free High-Throughput Screening of Protein-Ligand Interactions with timsTOF MALDI PharmaPulse
- Brochure rapifleX MALDI PharmaPulse - Label-free mass spectrometry, the universal tool for drug discovery
- Brochure timsTOF MALDI PharmaPulse - Unbiased, deep high-throughput screening by label-free mass spectrometry
- Brochure timsTOF MALDI Pharma Pulse Automation - End-to-end workflow support for label-free high-throughput screening accelerating drug discovery
Oligonucleotide analysis
Glycan analysis
- MT 140 - Simple and fast LC-free N-glycome profiling using neofleX benchtop MALDI-TOF/TOF and BioPharma Compass software
- MT 146 - N-glycan profiling of biotherapeutic monoclonal antibodies using Bruker’s timsTOF fleX and neofleX platforms and BioPharma Compass Software: a novel tool for smart lead development and selection in pharma-biotech R&D
- TN 61 - neofleX benchtop MALDI-TOF/TOF: Providing next-level MS/MS performance for more structural insight in life sciences applications
Polymers / functional materials
- MT 105 - MALDI-CID Study of Poly(methyl methacrylate)
- MT 121 - TLC-MALDI for analysis of industrial materials
- MT 126 - Polystyrene analysis using MALDI-TOF MS
- MT 127 - Surface Layer MALDI-MSI of Synthetic Materials on a Molecular Level
- MT 131 - Direct analysis of hard disk media lubricants using MALDI-TOF MS
- MT 134 - End-group analysis of Optical Media Material Polycarbonate by MALDI-TOF MS
- MT 135 - timsTOF analysis of the tacticity of Polydiethylacrylamide (PDEAA) and the controlled branching structure of Polymethylmethacrylate (PMMA)
- MT 136 - MALDI mass spectrometry of polyethylene glycol fatty acid ester
- MT 139 - End-group identification of structural isomeric polymers by CID-LIFT MS/MS
- AMS 19 - Kendrick Mass Defect Plots for Visualizing Polymer Spectra
- AMS 26 - Interpretation of Complex Polymer Spectra Using KMD Plots
Technology highlight: Highest sensitivity with MALDI-2
- MSI 18 -MALDI-2 for enhanced in situ N-glycan analysis
- MSI 20 - Mapping sterols in a marine flatworm-algae-system using MALDI-2 TIMS MS-imaging
- MSI 25 - Seperation of isobaric androgens in target tissues using chemical derivatization and MALDI-2 TIMS Imaging
- MSI 26 - MALDI-2 idenifies novel lipids associated to Alzheimer pathology
- MSI 27 - Progress towards out-of-the-box sub-cellular imaging by pairing microGRID and MALDI-2
- LCMS 173 - The combination of MALDI-2 and timsTOF fleX brings targeted drug imaging to the next level
- LCMS 182 - High-throughput experimentation reaction monitoring and analysis of chemistry synthesis products with ultrahigh-throughput 4D timsTOF fleX MALDI-2 technology
Technology highlight: High-fidelity Imaging with MRMS
- MRMS 74 - Tracking free-toxin distribution in xenografts after in-vivo ADC dosing by MALDI Imaging
- MRMS 81 - Imaging by MRMS reveals xenobiotics accumulation and plant response in Populus nigra leaves
- MRMS 83 - Tissue pathology of aging research revealed with lipid analysis using MRMS MALDI Imaging
- MRMS 85 - eXtreme Resolution (XR) mass spectrometry imaging of glycosphingolipids
- MSI 10 - Single Cell Lipid Analysis using the Bruker ultrafleXtreme TOF/TOF and the 7T solariX MRMS Mass Spectrometers
- MSI 11 - Interrogation of the Spatial Metabolome of Ginkgo biloba with High-resolution MALDI and LDI Mass Spectrometry Imaging
- MSI 12 - Designer drug analysis by forensic MALDI techniques
- MSI 16 - High-resolution climate reconstruction using MRMS MALDI Imaging
For Research Use Only. Not for use in clinical diagnostic procedures.