Atomic Force Microscope

Dimension FastScan Bio

Fast scanning for large samples

Dimension FastScan Bio

The Dimension FastScan Bio Atomic Force Microscope (AFM) enables high-resolution research of biological dynamics, with temporal resolution of up to 3 frames-per-second for live sample observations. What’s more, it does this while making the AFM easier to use than ever before. Built upon the world’s most advanced large-sample AFM platform, the FastScan Bio AFM adds specialized life science features to this platform for high-resolution, live-sample observation of interacting molecules, membrane proteins, DNA protein binding, inter-cellular signaling and many other dynamic biological studies.

panning, zooming and scanning
Allow researchers to observe and study how biomolecular mechanisms function.
sample engaging and controls
Deliver easy and immediate nanoscale bioimaging.
Smart Engage
Provide flexibility for commercially available or custom-made probes.

High-Resolution Biological Dynamics

In-situ high-resolution dynamic studies with nanoscale resolution are a reality for a rapidly evolving branch of biological research. Dimension FastScan Bio breaks longstanding barriers to provide these capabilities for routine experimentation. These breakthroughs allow many more researchers to observe and study biomolecular structures and mechanisms. FastScan Bio’s high-resolution and high-speed scanning provide the best available bio tool for the observation of molecules, proteins, DNA, RNA, living cell membranes and tissues, and many other dynamics studies.

Time series of (1:1) DOPC/DPPC supported planar lipid bilayers. Consecutive images, recorded at 0.16 frames-per-second, demonstrate the stability of the taller DPPC gel phase domains and hence the highly sensitive force control of FastScan at high scan speeds. Imaging was conducted using TappingMode™ under aqueous conditions. Height images are shown. (Image size = 3μm; Z-scale = 3.2nm.)

Technology Designed for Live Samples

FastScan Bio's innovative AFM technology enables high-speed scanning and a seamless user interface to render immediate panning, zooming and continuous tracking of samples in fluid. Bruker’s new innovative probe design with unique cantilever shape and coating enables an uprecedented combination of imaging speed and softness. The resulting system delivers the scanning speed required for high-resolution spatiotemporal studies with the greatest simplicity ever seen in a commercial AFM system.

  • Simplified sample engaging and controls for immediate imaging
  • Real-time panning, zooming and scanning
  • Feature tracking and Movie creation tool
  • Micro-volume fluid cell with controlled fluid exchange

Hear What Our Customers Have to Say

The FastScan Bio AFM has improved performance over conventional AFMs, as we have achieved resolution close to the helical repeat of the DNA strands that make up the origami nanotiles. The smaller FastScan probes and high stability of this AFM platform are key to obtaining high-resolution imaging under liquid. This improved resolution is helping us answer questions about the formation and stability of DNA origami for future nanomaterials applications.

Professor Neil Thomson, Astbury Centre for Structural Molecular Biology, University of Leeds, UK

The higher speed and stability of the FastScan Bio gives us the first direct insight into membrane nanodomain dynamics. The movies we capture of motion in model cell membranes under increasing temperature let us quantify domain line tensions and observe the breakdown of large lipid domains into much smaller nanoscale fluctuations. We can now directly correlate domain lifetime with size at and above the critical temperature.

Dr. Simon Connell, School of Physics and Astronomy, University of Leeds, UK

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