Quality Assessment of Biologics: Higher Order Structure (HOS) Analysis Using NMR
The webinar will describe how 2D NMR can offer protein biochemists unprecedented analytical precision. By assigning just one spectrum, users can obtain a unique fingerprint of a protein at an atomistic resolution. This non-destructive technique can also be combined with other complimentary techniques to gain even further insights into sample quality.
Examples of the spectral processing and statistical and chemometric analysis methods being developed to increase automation will also be described. Aside from enabling simultaneous analysis of large data volumes, the automation available today has almost advanced to the point that even non-experts will be able to acquire and analyse NMR spectra for decision making.
Key Topics
You will also learn:
- 2D NMR spectral fingerprinting for higher order structure analysis of biologics
- Application to biologics in their formulated state for structural assessment
- Benefits of the advances in automated data acquisition and analysis
- Reproducibility and robustness for inter-lab precision
- Practical, easy application of 2D NMR in the biopharma spa
- Bruker’s latest instrumentation and software for 2D NMR analysis