In this webinar, our expert guest speakers provide insights into their research using AFM and AFM-IR techniques, which includes the investigation of drug adsorption on metal carrier nanoparticles and characterization of virus-like particles.
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Atomic Force Microscopy (AFM) is an advanced multi-parametric imaging technique that enables the 3D imaging of the surface topography of living biological samples in the nm-range, the characterization of nanomechanical properties, and the visualization of structural changes occurring at the molecular level.
Nanoscale Infrared AFM spectroscopy and imaging (AFM-IR, which can be conducted on Bruker nanoIR platforms) measures spatially varying physical and chemical properties with nanoscale spatial resolution in samples as diverse as polymers, thin films, monolayers, and biological materials.
In this webinar, our expert guest speakers provide insights into their work using these techniques and speak on exciting applications in the field of life science and biomedical research. You can expect from this webinar to:
Find out more about the technology featured in this webinar or our other solutions for nano-IR or AFM for life science:
|The Drug/Metal Nanocarrier Connection: Characterization and Imaging Using Nanoscale Infrared Spectroscopy
|Dr. Natalia Piergies
|Nowadays, nanotechnology plays an important role in improving conventional therapies, in particular in the treatment of cancer. Drug delivery systems, based on nanosized vehicles, deliver therapeutic agents to the target site where they are released in a controlled manner. The critical step in designing effective drug/carrier conjugates is the formation of a stable connection between the drug and the carrier surface. Therefore, monitoring how the drug deposits onto the carrier and understanding precisely how it is attached to the carrier`s surface is of great importance. Application of surface-enhanced vibrational spectroscopy methods enables the detailed interpretation of the drug/metal nanocarrier connection. In this webinar, Dr. Natalia Piergies discusses the surface enhancement occurring in the AFM-IR technique and its use in the nanoscale imaging of drug/metal nanocarrier conjugates. This is a groundbreaking approach, as even subtle changes in drug adsorption behavior can be tracked at very high spatial resolution.
|Probing Bio-Interfaces using Atomic Force Microscopy and Complementary Techniques
|Dr. Aaron Elbourne
|Atomic force microscopy allows in situ nanoscale systems to be probed unlike many other techniques. In this talk, Dr Aaron Elbourne speaks about his recent use of the Bruker JPK - BioAFM (NanoWizard 4) in tandem with other high-resolution imaging techniques. Specifically, the use of AFM techniques to probe fungal biofilms, virus-like-particles (VLPs), nanoparticle-cell interactions, and cell-virus adhesion are discussed. In addition, hyperspectral Synchrotron-based IR-spectroscopy are highlighted as a complimentary technique to these studies.
Natalia Piergies, Ph.D., Assistant Professor, Department of Experimental Physics of Complex Systems, Institute of Nuclear Physics PAN
Aaron Elbourne, Ph.D., Postdoctoral Research Fellow, School of Science, RMIT University
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