Metabolomics

How Bruker provides all the “pieces” to solve the “metabolomics puzzle” by integrated and advanced technical solutions.

Metabolomics aims at a comprehensive qualitative and quantitative analysis of all small molecules present in a cell a tissue or an organism to study the interplay in response to intrinsic and extrinsic factors. Metabolomics recently caught up with complementary efforts to understand the genomes, transcriptomes and proteomes to establish holistic pictures of biological systems.

To determine functions of “unknown” genes in functional genomics studies, Metabolomics has gained increasing attention since changes in small molecule concentrations are closely related to the observed phenotype.

Also disease, drugs, or environmental variation  can perturb concentration and fluxes in intermediary metabolic pathways. These responses involve adjustment of intracellular and extra cellular environments in order to maintain homeostasis. Both perturbation and adjustment are expressed as changes in the normal patterns in cells and biofluids that are characteristic (a ‘fingerprint’) of the nature of the site of the action. These patterns can be evaluated using spectroscopic / spectrometric techniques combined with multivariate statistical methods to gain insight into the molecular response of a biological system. 

Metabolomic analysis must accurately determine even the slightest changes of molecular profile related to disease, disease progression, therapeutic intervention, genetic modification or environmental variation. Thanks to our latest innovations in hyphenated NMRLC-MSGC-MS and FT-IR technologies, Bruker remains the leader in integrated solutions for metabolomics.

Our systems can be used for a broad variety of targeted and non-targeted metabolomics studies. They are very well equipped to detect, identify, and measure metabolome molecules covering the entire metabolomics chemical space. Thus, Bruker provides all hardware and software “puzzle pieces” to give a complete picture of the metabolome.

If you want to know more about our metabolomics solutions make sure to visit our pages on the Compass PathwayScreener, MetaboScape and on the HMDB library.