核磁共振波谱法测定新冠病毒RNA 成分的二级结构

总览

抗击新冠病毒引起的全球大流行病是当前社会和科学面临的最大挑战。德国法兰克福大学核磁共振研究小组发起倡议,于2020年3月底成立了一个由30个小组组成的国际联盟。利用核磁共振波谱,他们正在针对所有与新冠病毒相关的蛋白质进行结构检测,而其中的RNA成分则正在形成新型药物的潜在靶点。 

此外,他们将用RNA和蛋白质来筛选一个片段数据库,这个片段库是为了便于后续化学操作而设计的。(在本次研讨会中)我们专注于本项目的RNA部分,还将介绍项目的生化背景、核磁共振分配策略,并展示我们的筛选结果。 

Speaker

Prof. Ashutosh Kumar
Prof. Ashutosh Kumar
Associate Professor, Department of Bioscience and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India
His work involves studying the structure and mechanism of action of protein complexes such SCF complex and specialized Nucleosome and amyloids using state of the art solid- state and solution-state NMR spectroscopy along with other Biophysical tools. Ashutosh has made significant contribution in developing NMR methods and applying those on complex biological macromolecules to deduce structure and dynamics of these molecules. Prof. Kumar received his M.Sc. in chemistry from IIT. Delhi followed by his PhD at the Tata Institute of Fundamental Research, Mumbai supervised by Prof. R. V. Hosur. He did his postdoctoral research work under the supervision of Prof. Marc Baldus, Prof. Adam Lange and Prof. C. Griesinger at MPI for Biophysical Chemistry Gottingen before coming back to IIT Bombay.