Fast Tapping on living cells - Bioscope Resolve is the only BioAFM that enables fast scanning while simultaneously providing the large piezo scanner range necessary for capturing the dynamic behavior of living cells in real time (XYZ = 100µm x 100µm x 15µm). The Fast Tapping capabilities of Resolve are truly a step forward in conducting high-resolution AFM studies at timescales relevant to cellular processes. Together with the integration of advanced optical microscopy and environmental control, live cell studies have never been easier.
Dynamics of cell migration – High-resolution Fast Tapping movies enable direct observation of membrane ruffling events and associated dynamic rearrangement of the actin cytoskeleton at the leading edge of a living endothelial cell. Images were obtained at 35 seconds/frame (left – 37µm scan size) and 12.5 seconds/frame (right - 27µm scan size).