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Metabolomics

How Bruker provides all the “pieces” to solve the “metabolomics puzzle” by integrated and advanced technical solutions.
Metabolomics

Solving the Metabolomics Puzzle

Metabolomics aims at a comprehensive qualitative and quantitative analysis of all small molecules present in a cell a tissue or an organism to study the interplay in response to intrinsic and extrinsic factors. Metabolomics recently caught up with complementary efforts to understand the genomes, transcriptomes and proteomes to establish holistic pictures of biological systems.

Establish Holistic Pictures of Biological Systems

Metabolomic analysis must accurately determine even the slightest changes of molecular profile related to disease, disease progression, therapeutic intervention, genetic modification or environmental variation.

Disease, drugs, or environmental variation  can perturb concentration and fluxes in intermediary metabolic pathways. These responses involve adjustment of intracellular and extra cellular environments in order to maintain homeostasis. Both perturbation and adjustment are expressed as changes in the normal

patterns in cells and biofluids that are characteristic (a "fingerprint") of the nature of the site of the action. These patterns can be evaluated using spectroscopic / spectrometric techniques combined with multivariate statistical methods to gain insight into the molecular response of a biological system.

To determine functions of “unknown” genes in functional genomics studies, Metabolomics has gained increasing attention since changes in small molecule concentrations are closely related to the observed phenotype.

Metabolomics Research Areas

Non-Targeted Metabolomics

Non-targeted metabolomics aims for a quick and reliable identification of small molecule biomarkers characteristic for a particular physiological state in response to internal or external perturbations.

Targeted Analysis - Biomarker Validation

Identified biomarkers can be validated in targeted metabolomics experiments, where typically a limited number of compounds are quantified in a large number of samples.

Lipidomics

In order to pinpoint lipids characteristic for a particular physiological state their confident identification is crucial. The 4D-Lipidomics™ workflows integrated in MetaboScape® addresses this task based on high quality MS/MS spectra acquired with PASEF®, rule based annotation and CCS-aware ID validation.

Metabolomics Application

Central to metabolomics is the aim of identifying potential small molecule biomarkers that correlate to a disease, drug toxicity, or genetic or environmental variation. Metabolomics has a high impact on the way how research is conducted in many application areas.

Metabolomics Solution

Confidently identifying compounds relevant for metabolic processes relies on several crucial steps, including sample preparation, data acquisition, data pre-processing and data evaluation. In order to simplify and harmonize this workflow, Bruker developed the T-ReX LC-QTOF solution:

Poster Hall Metabolomics

Find a collection of posters submitted for scientific conferences and reflecting different research areas in the field of metabolomics.

Thanks to our latest innovations in NMR, LC-MS and GC-MS technologies, Bruker remains the leader in integrated solutions for metabolomics.

Our systems can be used for a broad variety of targeted and non-targeted metabolomics studies. They are very well equipped to detect, identify, and measure metabolome molecules covering the entire metabolomics chemical space. Thus,

Bruker provides all hardware and software “puzzle pieces” to give a complete picture of the metabolome.If you want to know more about our metabolomics solutions make sure to visit our pages on the MetaboScape® and Metabolomics Spectral Libriaries.

 

For Research Use Only. Not for use in clinical diagnostic procedures.