timsTOF fleX Bibliography

timsTOF fleX Bibliography

The timsTOF fleX is a high performance UHR-OTOF system with integrated dual ESI/MALDI source, exhibiting high speed and robust MALDI Imaging. The additional trapped ion mobility feature adds another separation dimension to unravel complex data and make annotations in MALDI Images more reliable through CCS-matching. Since ASMS 2020 we switched to the next level to gain higher sensitivity for a broad range of compounds and equipped the instrument with a second laser allowing for postionization (MALDI-2).

MALDI-2 uses laser based postionization to enhance and enrich the MALDI experiment, providing access to chemical classes typically opaque to MALDI, at unprecedented sensitivity (2-3 orders of magnitude compared to traditional MALDI) Postionization significantly boosts ion yields for many different analytes and reduces the ever-challenging ion suppression effects in MALDI imaging.

The peer-reviewed and in-peer-reviewing communications listed below is a non-exhaustive list from the work initiated on the first timsTOF fleX (MALDI-2) instruments in the field in the years 2019-2023 and many more are to come.

timsTOF fleX

TITLE AUTHOR PUBLICATION LINK YEAR APPLICATION
Pulmonary maternal immune activation does not extend through the placenta but leads to fetal metabolic adaptation Hansen, S. S. K.; Krautz, R.; Rago, D. et al. bioRxiv 14, 2023, 8, 492 https://doi.org/10.1101/2023.03.17.532052 2023 Biology - Clinical
The microenvironment dictates glycocalyx construction and immune surveillance Tharp, K.; Park, S.; Timblin, G. et al. Research Square 4, 2023, 08-04, 2023.07.28.551042 https://doi.org/10.21203/rs.3.rs-3164966/v1 2023 Biology - Clinical
GolpHCat (TMEM87A): a unique voltage-gated and pH-sensitive cation channel in the Golgi Kang, H.; Jeong, H.; Han, A. et al. bioRxiv, 2023, e2300680 https://doi.org/10.1101/2023.01.03.522543 2023 Biology
Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19 Sugiura, Y.; Maeda, R.; Seki, N. et al. Research Square 4, 2023, 08-04, rs.3.rs-2276903 https://doi.org/10.21203/rs.3.rs-3114838/v1 2023 Biology - Clinical
A super-resolution strategy for mass spectrometry imaging via transfer learning Liao, T.; Ren, Z.; Chai, Z. et al. Nature Machine Intelligence, 2023 https://doi.org/10.1038/s42256-023-00677-7 2023 Method Development
Enhanced niche colonisation and competition during bacterial adaptation to a fungus Richter, A.; Blei, F.; Hu, G. et al. bioRxiv, 2023 https://doi.org/10.1101/2023.03.27.534400 2023 Biology
Interpretable dimensionality reduction and classification of mass spectrometry imaging data in a visceral pain model via non-negative matrix factorization Pathirage, K.; Virmani, A.; Scott, A. J. et al. bioRxiv 22, 2023, 8, 2694-2702 https://doi.org/10.1101/2023.04.24.538180 2023 Method Development
Competition for iron shapes metabolic antagonism between Bacillus subtilis and Pseudomonas Lyng, M.; Jørgensen, J. P. B.; Schostag, M. D. et al. bioRxiv 2688, 2023, 173-186 https://doi.org/10.1101/2023.06.12.544649 2023 Biology
Resistance towards and biotransformation of Pseudomonas-produced secondary metabolites during community invasion Hansen, M. L.; Dénes, Z.; Jarmusch, S. A. et al. bioRxiv 95, 2023, 28, 10603-10609 https://doi.org/10.1101/2023.06.20.545698 2023 Biology - Clinical
Investigating post-traumatic syringomyelia and local fluid osmoregulation via a rat model Pukale, D. D.; Adkins-Travis, K.; Aryal, S. R. et al. Research Square 76, 2023, 102362 https://doi.org/10.21203/rs.3.rs-3243600/v1 2023 Biology - Clinical
Fatty acids abrogate the growth-suppressive effects induced by inhibition of cholesterol flux in pancreatic cancer cells Li, Y.; Amrutkar, M.; Finstadsveen, A. V. et al. Research Square 43, 2023, 9, 1626-1635 https://doi.org/10.21203/rs.3.rs-3149861/v1 2023 Biology - Clinical
Unveiling the spatial metabolome and anti-atherosclerosis effects of Allium macrostemon Bunge and Allium chinense G. Don Li, S.; Lin, P.; Xing, H. et al. Arabian Journal of Chemistry 148, 2023, 13, 3002-3018 https://doi.org/10.1016/j.arabjc.2023.104772 2023 Biology - Clinical
ChIP-MS reveals the local chromatin composition by label-free quantitative proteomics Yong, W. K.; Rane, G.; Anuar, N. Z. et al. bioRxiv, 2023, 2023.06.23.546317 https://doi.org/10.1101/2023.01.27.525999 2023 Method Development
FluoMALDI microscopy: matrix co-crystallization simultaneously enhances fluorescence and MALDI imaging Yang, E.; Shen, X. E.; West-Foyle, H. et al. bioRxiv, 2023, 2023.06.20.545698 https://doi.org/10.1101/2023.05.27.542340 2023 Method Development
Omics Scale Quantitative Mass Spectrometry Imaging of Lipids in Brain Tissue using a Multi-Class Internal Standard Mixture Vandenbosch, M.; Mutuku, S. M.; Mantas, M. J. Q. et al. bioRxiv 14, 2023, 1, 3287 https://doi.org/10.1101/2023.06.21.546027 2023 Method Development
Cocaine Regulates Antiretroviral Therapy CNS Access Through Pregnane-X Receptor-Mediated Drug Transporter and Metabolizing Enzyme Modulation at the Blood Brain Barrier Fridman, L. B.; Knerler, S.; Price, A. et al. bioRxiv 24, 2023, 8, e56439 https://doi.org/10.1101/2023.07.28.551042 2023 Biology - Clinical
Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice Parhizkar, S.; Gent, G.; Chen, Y. et al. Science Translational Medicine, 2023 https://doi.org/10.1126/scitranslmed.ade6285 2023
3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib Meraz, I. M.; Majidi, M.; Fang, B. et al. Communications Biology 5, 2023, 6, 656-668 https://doi.org/10.1038/s42003-023-04889-w 2023 Biology - Clinical
Coordinated adaptations define the ontogenetic shift from worm- to fish-hunting in a venomous cone snail Rogalski, A.; Himaya, S. W. A.; Lewis, R. J. et al. Nature Communications, 2023 https://doi.org/10.1038/s41467-023-38924-5 2023 Biology
Reducing oxidative protein folding alleviates senescence by minimizing ER‐to‐nucleus H2O2 release Cheng, F.; Ji, Q.; Wang, L. et al. EMBO Reports 16, 2023, 6, 104772 https://doi.org/10.15252/embr.202256439 2023
Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis Gui, W.; Hole, M. J.; Molinaro, A. et al. Nature Communications, 2023, 100630 https://doi.org/10.1038/s41467-023-38840-8 2023 Biology - Clinical
Using mass spectrometry imaging to map fluxes quantitatively in the tumor ecosystem Schwaiger-Haber, M.; Stancliffe, E.; Anbukumar, D. S. et al. Nature Communications 8, 2023, 2_suppl, 3-669 https://doi.org/10.1038/s41467-023-38403-x 2023 Biology - Clinical
Incorporating Anticoagulant and Antiplatelet Dual Functional Groups into Thermosetting Polymer Chain for Enhancing Antithrombogenicity Wang, W.; Liu, S.; Zhang, S. et al. Advanced Healthcare Materials, 2023 https://doi.org/10.1002/adhm.202300680 2023
Strategic self-limiting production of infectious HIV particles by CRISPR in permissive cells Liu, H.; Chen, C.; Liao, S. et al. Molecular Therapy - Nucleic Acids 14, 2023, 1, 2876 https://doi.org/10.1016/j.omtn.2023.04.027 2023 Biology
Strigolactones repress nodule development and senescence in pea Van Dingenen, J.; De Keyser, A.; Desmet, S. et al. The Plant Journal 32, 2023, 1010-1025 https://doi.org/10.1111/tpj.16421 2023 Biology
Photoreduction of Anthracenes Catalyzed by peri‐Xanthenoxanthene: a Scalable and Sustainable Birch‐type Alternative De Luca, C.; Zanetti, D.; Battisti, T. et al. Chemistry - A European Journal 12, 2023, Suppl 1, e12329 https://doi.org/10.1002/chem.202302129 2023 Chemistry – Basic Research
Integrated mass spectrometry imaging and single‐cell transcriptome atlas strategies provide novel insights into taxoid biosynthesis and transport in Taxus mairei stems Yu, C.; Hou, K.; Zhang, H. et al. The Plant Journal, 2023, 2023.05.13.540426 https://doi.org/10.1111/tpj.16315 2023 Biology
Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis Conroy, L. R.; Clarke, H. A.; Allison, D. B. et. al. Nature Communications 14, 2023, 1, 2759 https://doi.org/10.1038/s41467-023-38437-1 2023 Biology - Clinical
WSD-0922, a novel brain-penetrant inhibitor of epidermal growth factor receptor, promotes survival in glioblastoma mouse models Conage-Pough, J. E.; Stopka, S. A.; Oh, J. et al. Neuro-Oncology Advances 1265, 2023, 341267 https://doi.org/10.1093/noajnl/vdad066 2023 Biology - Clinical
Exposure to isocyanates predicts atopic dermatitis prevalence and disrupts therapeutic pathways in commensal bacteria Zeldin, J.; Chaudhary, P. P.; Spathies, J. et al. Science Advances 380, 2023, 6644, 520-526 https://doi.org/10.1126/sciadv.ade8898 2023 Biology - Clinical
Analysis of N-linked glycan alterations in tissue and serum reveals promising biomarkers for intrahepatic Cholangiocarcinoma Ochoa-Rios, S.; Blaschke, C. R. K.; Wang, M. et al. Cancer Research Communications 11, 2023, 1182404 https://doi.org/10.1158/2767-9764.crc-22-0422 2023 Biology - Clinical
Laser desorption/ionization-mass spectrometry for the analysis of interphases in lithium ion batteries Göldner, V.; Quach, L.; Adhitama, E. et al. iScience 95, 2023, 19, 7475-7486 https://doi.org/10.1016/j.isci.2023.107517 2023 Chemistry – Basic Research
Elucidation of the environmental reductive metabolism of the herbicide tritosulfuron assisted by electrochemistry and mass spectrometry Göldner, V.; Speitling, M.; Karst, U. Chemosphere 15, 2023, 693, eade6285 https://doi.org/10.1016/j.chemosphere.2023.138687 2023 Chemistry – Basic Research, Environmental, pollution
Macromolecular Engineering: From Precise Macromolecular Inks to 3D Printed Microstructures Catt, S. O.; Hackner, M.; Spatz, J. P. et al. Small, 2023, e2300844 https://doi.org/10.1002/smll.202300844 2023 Chemistry – Basic Research
Metabolomics of bacterial–fungal pairwise interactions reveal conserved molecular mechanisms Luu, G. T.; Little, J. C.; Pierce, E. C. et al. Analyst, 2023, 333-357 https://doi.org/10.1039/d3an00408b 2023 Biology
Direct mass spectrometric imaging of document handwriting with laser desorption ionization and post ultraviolet photodissociation Jia, S.; Zhou, X.; Hu, X. et al. Analytica Chimica Acta, 2023, 2023.03.27.534400 https://doi.org/10.1016/j.aca.2023.341267 2023 Chemistry – Basic Research, Forensic
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling Altea-Manzano, P.; Doglioni, G.; Liu, Y. et al. Nature Cancer 4, 2023, 03-29, 2023.03.23.533981 https://doi.org/10.1038/s43018-023-00513-2 2023
Bioorthogonal Chemical Labeling Probes Targeting Sialic Acid Isomers for N‑Glycan MALDI Imaging Mass Spectrometry of Tissues, Cells, and Biofluids Lu, X.; McDowell, C. T.; Blaschke, C. R. K. et al. Analytical Chemistry, 2023, 2023.03.17.532052 https://doi.org/10.1021/acs.analchem.2c04882 2023 Method Development
In vitro and ex vivo proteomics of Mycobacterium marinum biofilms and the development of biofilm-binding synthetic nanobodies Hammarén, M. M.; Luukinen, H.; Sillanpää, A. et al. mSystems, 2023 https://doi.org/10.1128/msystems.01073-22 2023 Biology - Clinical
Expression of transglutaminase 2 in human gut epithelial cells: Implications for coeliac disease Amundsen, S. F.; Stamnaes, J.; Lundin, K. E. A. et al. PLOS ONE 30, 2023, Suppl 1, 1-324 https://doi.org/10.1371/journal.pone.0287662 2023 Biology - Clinical
Towards optimised extracellular vesicle proteomics from cerebrospinal fluid Kangas, P.; Nyman, T. A.; Metsähonkala, L. et al. Scientific Reports 4, 2023, 03-29, 2023.03.13.532449 https://doi.org/10.1038/s41598-023-36706-z 2023 Biology, Method Development
Spatial probabilistic mapping of metabolite ensembles in mass spectrometry imaging Abu Sammour, D.; Cairns, J. L.; Boskamp, T. et al. Nature Communications, 2023, 425-480 https://doi.org/10.1038/s41467-023-37394-z 2023 Method Development
Mobility-resolved broadband dissociation and parallel reaction monitoring for laser desorption/ionization-mass spectrometry - Tattoo pigment identification supported by trapped ion mobility spectrometry Wolf, C.; Behrens, A.; Brungs, C. et al. Analytica Chimica Acta 34, 2023, 4, 720-727 https://doi.org/10.1016/j.aca.2023.340796 2023 Method Development
Evaluating the Pharmacokinetics and Pharmacodynamics of Chemotherapeutics within a Spatial SILAC-Labeled Spheroid Model System Beller, N. C.; Wang, Y.; Hummon, A. B. Analytical Chemistry 3, 2023, 3, 383-394 https://doi.org/10.1021/acs.analchem.3c00905 2023 Biology - Clinical, Method Development
De novo phytosterol synthesis in animals Michellod, D.; Bien, T.; Birgel, D. et al. Science 7, 2023, 1, 22 https://doi.org/10.1126/science.add7830 2023
Microscopy-Directed Imaging Mass Spectrometry for Rapid High Spatial Resolution Molecular Imaging of Glomeruli Esselman, A. B.; Patterson, N. H.; Migas, L. G. et al. Journal of The American Society for Mass Spectrometry 42, 2023, 5, 1984-2206 https://doi.org/10.1021/jasms.3c00033 2023 Method Development
Analysis of single cells treated with the KRASG12D inhibitor MRTX 1133 reveals new challenges for the emerging field of single cell proteomics Orsburn, B. C. bioRxiv, 2023, 2023.02.20.529255 https://doi.org/10.1101/2023.03.23.533981 2023 Biology
High-Resolution N‑Glycan MALDI Mass Spectrometry Imaging of Subchondral Bone Tissue Microarrays in Patients with Knee Osteoarthritis Lee, Y.; Briggs, M. T.; Kuliwaba, J. S. et al. Analytical Chemistry 13, 2023, 1, 2776 https://doi.org/10.1021/acs.analchem.3c00348 2023 Biology - Clinical
Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation Li, M.; Wu, X.; Jing, W. et al. Cell Death & Disease 4, 2023, 3, 344-364 https://doi.org/10.1038/s41419-023-06017-2 2023 Biology - Clinical
Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation Miller, A.; York, E.; Stopka, S. et al. Research Square, 2023, 2023.01.27.525999 https://doi.org/10.21203/rs.3.rs-2276903/v1 2023 Biology - Clinical
Spatially Resolved Metabolites in Stable and Unstable Human Atherosclerotic Plaques Identified by Mass Spectrometry Imaging Seeley, E. H.; Liu, Z.; Yuan, S. et al. Arteriosclerosis Thrombosis and Vascular Biology 95, 2023, 4, 2329-2338 https://doi.org/10.1161/atvbaha.122.318684 2023 Biology - Clinical
Optimized protocol for MALDI MSI of N-glycans using an on-tissue digestion in fresh frozen tissue sections Grgic, A.; Krestensen, K. K.; Heeren, R. M. A. Scientific Reports 95, 2023, 1, 134-151 https://doi.org/10.1038/s41598-023-29560-6 2023 Protocol
Development of an Antibody-Based Platform for the Analysis of Immune Cell-Specific N‑linked Glycosylation Dressman, J. W.; McDowell, C. T.; Lu, X. et al. Analytical Chemistry 51, 2023, 3, dmd-mr-2022-001043 https://doi.org/10.1021/acs.analchem.3c00838 2023 Method Development
Complex-Type N‑Glycans Are Associated with Cartilage Degeneration within Different Loading Sites of the Tibial Plateau for Knee Osteoarthritis Patients Lee, Y.; Briggs, M. T.; Kuliwaba, J. S. et al. Journal of Proteome Research 1242, 2023, 340796 https://doi.org/10.1021/acs.jproteome.3c00251 2023 Biology - Clinical
MALDI HiPLEX-IHC: multiomic and multimodal imaging of targeted intact proteins in tissues Lim, M. J.; Yagnik, G.; Henkel, C. et al. Frontiers in Chemistry 43, 2023, 1, 28-29 https://doi.org/10.3389/fchem.2023.1182404 2023 Method Development
MALDI-IHC-Guided In-Depth Spatial Proteomics: Targeted and Untargeted MSI Combined Claes, B. S. R.; Krestensen, K. K.; Yagnik, G. et al. Analytical Chemistry 5, 2023, 1, vdad066 https://doi.org/10.1021/acs.analchem.2c04220 2023 Biology, Method Development
Visualization of Differential Cardiolipin Profiles in Murine Retinal Cell Layers by High-Resolution MALDI Mass Spectrometry Imaging Bessler, S.; Soltwisch, J.; Dreisewerd, K. Analytical Chemistry 2670, 2023 https://doi.org/10.1021/acs.analchem.3c01465 2023 Biology
Enhancement of Lipid Signals in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry with Ammonium Fluoride as a Matrix Additive Holbrook, J. H.; Sekera, E. R.; Lopez, A. et al. Analytical Chemistry 119, 2023 https://doi.org/10.1021/acs.analchem.3c00753 2023 Method Development
A Multimodal SIMS/MALDI Mass Spectrometry Imaging Source with Secondary Electron Imaging Capabilities for Use with timsTOF Instruments Krijnen, K.; Keelor, J. D.; Böhm, S. et al. Journal of The American Society for Mass Spectrometry 2688, 2023 https://doi.org/10.1021/jasms.2c00381 2023 Method Development
Towards optimised extracellular vesicle proteomics from cerebrospinal fluid Kangas, P.; Nyman, T. A.; Metsähonkala, L. et al. bioRxiv https://doi.org/10.1101/2022.09.27.508990 2022 Biology - Clinical
HOMO Energy-Level Lifting in p-Type O-Doped Graphenoids: Synthesis of Electrochromic Alkoxy-Decorated Xanthenoxanthenes Rossignon, A.; Berna, B. B.; Parola, A. J. et al. Organic Materials, 4(04), 240-254 https://doi.org/10.1055/a-1976-0291 2022 Chemistry – Basic Research
Applying imaging mass spectrometry to define the N-glycan profiles of co-localized virus and immune cell infiltrates in post-COVID-19 infected lung autopsy tissues Jones,E. E.; Drake, R. R.; Dressman, J. W. et al. Frontiers in Analytical Science, 2, 1021008 https://doi.org/10.3389/frans.2022.1021008 2022 Biology - Clinical
Deep topographic proteomics of a human brain tumour Davis, S.; Scott, C.; Oetjen, J. et al. bioRxiv https://doi.org/10.1101/2022.03.21.485119 2022 Biology
Single Cell Proteomics Using a Trapped Ion Mobility Time-of-Flight Mass Spectrometer Provides Insight into the Post-translational Modification Landscape of Individual Human Cells Orsburn, B. C.; Yuan, Y.; Bumpus, N. bioRxiv https://doi.org/10.1101/2022.02.12.480144 2022 Biology
BAF complex maintains glioma stem cells in pediatric H3K27M-glioma Panditharatna, E.; Marques, J. G.; Wang, T. et al. Cancer Discovery, 12(12), 2880-2905 https://doi.org/10.1158/2159-8290.cd-21-1491 2022 Biology - Clinical
Thiosemicarbazone Derivatives Developed to Overcome COTI-2 Resistance Pósa, V.; Stefanelli, A.; Nunes, J. H. B. et al. Cancers, 14(18), 4455 https://doi.org/10.3390/cancers14184455 2022 Biology - Clinical
Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer Villar, V. H.; Allega, M. F.; Deshmukh, R. et al. Nature Chemical Biology, 1-9 https://doi.org/10.1038/s41589-022-01154-9 2022 Biology
A chromosome-level genome of Isodon rubescens reveals that tandem-duplicated CYP706V oxidase genes control oridonin biosynthesis in shoot apex Sun, Y.; Shao, J.; Liu, H. et al. Molecular Plant https://doi.org/10.1016/j.molp.2022.12.007 2022 Biology
Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids Liu, X.; Li, C.; Wan, Z. et al. Signal Transduction and Targeted Therapy, 7(1), 392 https://doi.org/10.1038/s41392-022-01247-w 2022 Biology
Energy metabolism in skeletal muscle cells from donors with different body mass index Katare, P. B.; Dalmao-Fernandez, A.; Mengeste, A. M. et al. Frontiers in Physiology, 13, 982842 https://doi.org/10.3389/fphys.2022.982842 2022 Biology
Label-free quantitative proteomics and immunoblotting identifies immunoreactive and other excretory-secretory (E/S) proteins of Anoplocephala perfoliata Hautala, K.; Pursiainen, J.; Näreaho, A. et al. Frontiers in Immunology, 13, 1045468 https://doi.org/10.3389/fimmu.2022.1045468 2022 Biology
Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid α/β‑Hydrolase Domain 6 (ABHD6) Mardon, K.; Patel, J. Z.; Savinainen, J. R. et al. Journal of Medicinal Chemistry https://doi.org/10.1021/acs.jmedchem.2c01485 2022 Biology
Fallopian tube secreted protein affects ovarian metabolites in high grade serous ovarian cancer Bergsten, T. M.; Levy, S. E.; Zink, K. E. et al. Frontiers in Cell and Developmental Biology, 10, 1042734 https://doi.org/10.3389/fcell.2022.1042734 2022 Biology - Clinical
Isolation of a cytolytic subpopulation of extracellular vesicles derived from NK cells containing NKG7 and cytolytic proteins Aarsund, M.; Nyman, T. A.; Stensland, M. E. et al. Frontiers in Immunology, 13, 977353 https://doi.org/10.3389/fimmu.2022.977353 2022 Biology - Clinical
Optimization of Zebrafish Larvae Sectioning for Mass Spectrometry Imaging Yang, J.; Rendino, L.; Cassar, S. et al. Pharmaceuticals, 15(10), 1230 https://doi.org/10.3390/ph15101230 2022 Method Development
Integrating age, BMI, and serum N-glycans detected by MALDI mass spectrometry to classify suspicious mammogram findings as benign lesions or breast cancer Blaschke, C. R. K.; Hill, E. G.; Mehta, A. S. et al. Scientific Reports, 12(1), 20801 https://doi.org/10.1038/s41598-022-25401-0 2022 Biology - Clinical
PARP-inhibition reprograms macrophages toward an anti-tumor phenotype Wang, L.; Wang, D.; Sonzogni, O. et al. Cell Reports, 41(2), 111462 https://doi.org/10.1016/j.celrep.2022.111462 2022 Biology - Clinical
Chiral‐at‐Metal Silver‐Mediated Base Pairs: Metal‐Centred Chirality versus DNA Helical Chirality Lefringhausen, N.; Seiffert, V.; Erbacher, C. et al. Chemistry - A European Journal, e202202630 https://doi.org/10.1002/chem.202202630 2022 Chemistry – Basic Research
Spatial segmentation of mass spectrometry imaging data featuring selected principal components Zou, Y.; Tang, W.; Li, B. Talanta, 253, 123958 https://doi.org/10.1016/j.talanta.2022.123958 2022 Method Development
Device-Controlled Microcondensation for Spatially Confined On-Tissue Digests in MALDI Imaging of N-Glycans Fülöp, A.; Marsching, C.; Barka, F. et al. Pharmaceuticals, 15(11), 1356 https://doi.org/10.3390/ph15111356 2022 Method Development
Insights into protein post-translational modification landscapes of individual human cells by trapped ion mobility time-of-flight mass spectrometry Orsburn, B. C.; Yuan, Y.; Bumpus, N. et al. Nature Communications, 13(1), 7246 https://doi.org/10.1038/s41467-022-34919-w 2022 Biology
Visualizing the Distribution of Lipids in Peanut Seeds by MALDI Mass Spectrometric Imaging Wang, X., Chen, Y., Liu, Y. et al. Foods, 11(23), 3888 https://doi.org/10.3390/foods11233888 2022 Biology
Mass Spectrometry Imaging of Lipids Using MALDI Coupled with Plasma-Based Post-Ionization on a Trapped Ion Mobility Mass Spectrometer Michael, J. A.; Mutuku, S. M.; Ucur, B. et al Anal. Chem. 94, 50 https://doi.org/10.1021/acs.analchem.2c03745 2022 Method Development
Chiral derivatization-enabled discrimination and on-tissue detection of proteinogenic amino acids by ion mobility mass spectrometry Chengyi, X.; Yanyan, C.; Xiaoxiao, W. et al. Xin Diao, Lin Zhu, Jianing Wang and Zongwei Cai November 2022. Chemical Science https://doi.org/10.1039/d2sc03604e 2022 Method Development
3‑Acetylpyridine On-Tissue Paternò−Büchi Derivatization Enabling High Coverage Lipid C=C Location-Resolved MS Imaging in Biological Tissues Yanyan, C.; Chengyi, X.; Xiaoxiao, W. et al. Min Li, Jianing Wang,* and Zongwei Cai* Anal. Chem. 2022, 94, 15367−15376 https://doi.org/10.1021/acs.analchem.2c03089 2022 Method Development
Visual authentication of steroidal saponins in Allium macrostemon Bge. and Allium chinense G. Don using MALDI-TOF imaging mass spectrometry and their structure activity relationship Duan, S.; Li, X.; Yao, Z. et al. Arabian Journal of Chemistry, 15(10), 104138 https://doi.org/10.1016/j.arabjc.2022.104138 2022 Biology
Variation in blood microbial lipopolysaccharide (LPS) contributes to immune reconstitution in response to suppressive antiretroviral therapy in HIV Luo, Z.; Health, S. L.; Li, M. et al. EBioMedicine, 80, 104037 https://doi.org/10.1016/j.ebiom.2022.104037 2022 Biology - Clinical
Unraveling metabolic alterations in transgenic mouse model of Alzheimer's disease using MALDI MS imaging with 4-aminocinnoline-3-carboxamide matrix Chen, Y.; Hu, D.; Zhao, L.; Tang, W.; Li, B. Analytica Chimica Acta, 1192, 2021, 339337 https://www.sciencedirect.com/science/article/abs/pii/S0003267021011636 2022 Biology - Clinical
TIMSCONVERT: A workflow to convert trapped ion mobility data to open data formats Luu, G. T.; Lizama-Chamu, I.; McCaughey, C. S. et al. Bioinformatics, 38(16), 2022, 4046–4047, https://doi.org/10.1093/bioinformatics/btac419 2022 Protocol
Tattoo Pigment Identification in Inks and Skin Biopsies of Adverse Reactions by Complementary Elemental and Molecular Bioimaging with Mass Spectral Library Matching Brungs, C.; Schmid, R.; Wolf, C. et al. Analytical Chemistry, 94(8), 2022, 3581-3589 https://doi.org/10.1021/acs.analchem.1c04922 2022 Chemistry – Basic Research
Targeting keratin 17-mediated reprogramming of de novo pyrimidine biosynthesis to overcome chemoresistance in pancreatic cancer Pan, C.; Chaika, N. V.; Tseng, R. et al. bioRxiv https://doi.org/10.1101/2022.08.24.504873 2022 Biology - Clinical
Synthesis and Functionalization of Challenging meso-Substituted Aryl Bis-pocket Porphyrins Accessed via Suzuki–Miyaura Cross-Coupling Droege, D. G.; Parker, A. L.; Milligan, G. M. et al. The Journal of Organic Chemistry, 87(17), 11783-11795 https://doi.org/10.1021/acs.joc.2c01538 2022 Chemistry – Basic Research
Structural characterization and analysis of different epimers of neutral glycosphingolipid LcGg4 by ion mobility spectrometry-mass spectrometry Gao, T.; Aneirin A Lott, A. A.; Huang, F. et al. Analyst, 147(13), 2022, 3101-3108 https://doi.org/10.1039/d2an00224h 2022 Chemistry – Basic Research
Spatially Resolved Metabolites in Stable and Vulnerable Human Atherosclerotic Plaques Identified by Mass Spectrometry Imaging Seeley, E. H.; Liu, Z.; Yuan, S. et al. bioRxiv https://doi.org/10.1101/2022.05.30.494038 2022 Biology - Clinical
Spatially resolved characterization of tissue metabolic compartments in fasted and high-fat diet livers Stopka, S. A.; van der Reest, J.; Abdelmoula, W. M. et al. PLOS ONE, 17(9), e0261803 https://doi.org/10.1371/journal.pone.0261803 2022 Biology - Clinical
Single‐Cell Proteomic Profiling of Hepatocytes Reveals Heterogeneous Responses to Hepatotoxic Drugs Nevirapine, Efavirenz, and Acetaminophen Yuan, Y.; Orsburn, B. C.; Bumpus, N. The FASEB Journal, 36(S1) https://doi.org/10.1096/fasebj.2022.36.S1.R4856 2022 Biology - Clinical
Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma Coy, S.; Wang, S.; Stopka, S. A. et al. Nature Communications, 13(1), 4814 https://doi.org/10.1038/s41467-022-32430-w 2022 Biology - Clinical
Shielding the oil reserves: the scutellum as a source of chemical defenses Murphy, K. M.; Poretsky, E.; Liu, H. et al. Plant Physiology, 188(4), 1944-1949 https://doi.org/10.1093/plphys/kiac038 2022 Biology
Rewiring of the N-Glycome with Prostate Cancer Progression and Therapy Resistance Butler, W.; McDowell, C.; He, Y. et al. npj Precision Oncology 7, 2023, 22 https://www.nature.com/articles/s41698-023-00363-2 2022 Biology - Clinical
Proteomic analysis of Mycobacterial Biofilm Matrix and Development of Biofilm-binding Synthetic Nanobodies Hammarén, M.; Luukinen, H.; Sillanpää, A. et al. Research Square https://doi.org/10.21203/rs.3.rs-1588905/v1 2022 Biology - Clinical
Optimizing data‐independent acquisition (DIA) spectral library workflows for plasma proteomics studies Rice, S. J.; Belani, C. P. Proteomics, 22(17), 2022, 2200125 https://doi.org/10.1002/pmic.202200125 2022 Protocol
One-Pot Chemoenzymatic Synthesis of Microviridin Analogs Containing Functional Tags Scholz, S.; Kerestetzopoulou, S.; Wiebach, V. et al. ChemBioChem, 2022 https://doi.org/10.1002/cbic.202200345 2022 Method Development
N-Succinyltransferase Encoded by a Cryptic Siderophore Biosynthesis Gene Cluster in Streptomyces Modifies Structurally Distinct Antibiotics Schneider, O.; Zehl, M.; Ueoka, R. et al. mBio, e01789-22 https://doi.org/10.1128/mbio.01789-22 2022 Biology - Clinical
Novel Combined Enzymatic Approach to Analyze Nonsialylated N-Linked Glycans through MALDI Imaging Mass Spectrometry Andrew, T. D.; Hongyan, L.; Richard, R. D. et al. J Proteome Res. 21(8), 2022, 1930-1938 https://doi.org/10.1021/acs.jproteome.2c00193 2022 Biology - Clinical
Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox Xie, J.; Robinson, S. D.; Gilding, E. K. et al. Journal of Biological Chemistry, 298(8), 102218 - https://doi.org/10.1016/j.jbc.2022.102218 2022 Biology
Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells, biomarkers, and response to substrate reduction therapy Boddupalli, C. S.; Nair, S.; Belinsky, G. et al. eLife, 11, e79830 https://doi.org/10.7554/elife.79830 2022 Biology - Clinical
Neglected Very Long-Chain Hydrocarbons and the Incorporation of Body Surface Area Metrics Reveal Novel Perspectives for Cuticular Profile Analysis in Insects Golian, M.; Bien, T.; Schmelzle, S. et al. Insects, 13, 2022, 83 https://doi.org/10.3390/insects13010083 2022 Biology
Monosialotetrahexosylganglioside Promotes Early Aβ42 Oligomer Formation and Maintenance Zhang, D. Y.; Wang, J.; Fleeman, R. M. et al. ACS Chemical Neuroscience, 13(13), 1979-1991 https://doi.org/10.1021/acschemneuro.2c00221 2022 Biology - Clinical
Mass spectrometry imaging to explore molecular heterogeneity in cell culture Bien, T.; Koerfer, K.; Schwenzfeier, J. et al. Proceedings of the National Academy of Sciences of the United States of America, 119(29), e2114365119 https://doi.org/10.1073/pnas.2114365119 2022 Biology
MALDI Mass Spectrometry Imaging for the Distinction of Adenocarcinomas of the Pancreas and Biliary Tree Bollwein, C.; Gonҫalves, J. P. L.; Utpatel, K. et al. Molecules, 27(11), 3464 https://doi.org/10.3390/molecules27113464 2022 Biology - Clinical
LPS-induced lipid alterations in microglia revealed by MALDI mass spectrometry-based cell fingerprinting in neuroinflammation studies Blank, M.; Enzlein, T.; Hopf, C. et al. Scientific Reports, 12(1), 2022, 2908 https://doi.org/10.1038/s41598-022-06894-1 2022 Biology - Clinical
Lactate is an epigenetic metabolite that drives survival in model systems of glioblastoma Torrini, C.; Nguyen, T. T. T.; Shu, C. et al. Molecular Cell, 82(16), 3061-3076.e6 https://doi.org/10.1016/j.molcel.2022.06.030 2022 Biology - Clinical
Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context Goossens, P.; Lu, C.; Cao, J. et al. Cell Metabolism, 34(8), 1214-1225.e6 https://doi.org/10.1016/j.cmet.2022.06.012 2022 Biology - Clinical
Insight Into the Metabolic Adaptations of Electrically Pulse-Stimulated Human Myotubes Using Global Analysis of the Transcriptome and Proteome Mengeste, A. M.; Nikolić, N.; Fernandez, A. D. et al. Frontiers in Physiology, 13, 928195 https://doi.org/10.3389/fphys.2022.928195 2022 Biology
In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues Young, L. E. A.; Conroy, L. R.; Clarke, H. A. et al. EMBO Molecular Medicine, e16029 https://doi.org/10.15252/emmm.202216029 2022 Biology
Imaging Mass Spectrometry Reveals Complex Lipid Distributions Across Staphylococcus aureus Biofilm Layers Rivera, E. S.; Weiss, A.; Migas, L. G. et al. Journal of Mass Spectrometry and Advances in the Clinical Lab, in press https://doi.org/10.1016/j.jmsacl.2022.09.003 2022 Biology
Imaging Mass Spectrometry Reveals Alterations in N-Linked Glycosylation That Are Associated With Histopathological Changes in Nonalcoholic Steatohepatitis in Mouse and Human Ochoa-Rios, S.; O'Connor, I. P.; Kent, L. N. et al. Molecular & Cellular Proteomics, 21(5), 100225 https://doi.org/10.1016/j.mcpro.2022.100225 2022 Biology - Clinical
Home-Built Spinning Apparatus for Drying Agarose-Based Imaging Mass Spectrometry Samples Lusk, H. J.; Levy, S. E.; Bergsten, T. M. et al. Journal of The American Society for Mass Spectrometry, 33(7), 1325-1328 https://doi.org/10.1021/jasms.2c00044 2022 Protocol
Forensic Discrimination of Differentially Sourced Animal Blood Using a Bottom-Up Proteomics Based MALDI MS Approach Kennedy, K.; Cole, L.; Witt, M. et al. Molecules, 27(7), 2022, 2039 https://doi.org/10.3390/molecules27072039 2022 Forensic
Establishment of a transparent soil system to study Bacillus subtilis chemical ecology Lozano-Andrade, C. N.; Nogueira, C. G.; Wibowo, M. et al. bioRxiv https://doi.org/10.1101/2022.01.10.475645 2022 Biology
Development of an Automatic Ultrasonic Matrix Sprayer for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Meng, L.; Han, J.; Chen, J. et al. Analytical Chemistry, 94(17), 2022, 6457-6462 https://doi.org/10.1021/acs.analchem.2c00403 2022 Method Development
Development of a cell‐free strategy to recover aged skeletal muscle after disuse Wu, Y.; De La Toba, E. A.; Dvoretskiy, S. et al. The Journal of Physiology, 600(13), 3029-3030 https://doi.org/10.1113/JP282867 2022 Biology - Clinical
De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma Shi, D. D.; Savani, M. R.; Levitt, M. M. et al. Cancer Cell, 40(9), 939-956.e16 https://doi.org/10.1016/j.ccell.2022.07.011 2022 Biology - Clinical
Composition and abundance of midgut surface proteins in the Asian citrus psyllid, Diaphorina citri Tavares, C. S.; Mishra, R.; Ghobrial, P. N. et al. Journal of Proteomics, 261, 2022, 104580 https://doi.org/10.1016/j.jprot.2022.104580 2022 Biology
Co-culture with Acinetobacter johnsonii enhances benzalkonium chloride resistance in Salmonella enterica via triggering lipid A modifications Wilson, A.; Fegan, N.; Turner, M. S. et al. International Journal of Food Microbiology, 381, 109905 https://doi.org/10.1016/j.ijfoodmicro.2022.109905 2022 Biology
Chiral Derivatization-enabled Discrimination and Visualization of Proteinogenic Amino Acids by Ion Mobility Mass Spectrometry Xie, C.; Chen, Y.; Wang, X. et al. bioRxiv https://doi.org/10.1101/2022.07.04.498692 2022 Chemistry – Basic Research
A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine Sebastian, C.; Ferrer, C.; Serra, M. et al. Nature Communications, 13(1), 2022, 1503 https://doi.org/10.1038/s41467-022-29085-y 2022 Biology - Clinical
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma Pal, S.; Kaplan, J. P.; Nguyen, H. et al. Cancer Cell, 40(9), 957-972.e10 https://doi.org/10.1016/j.ccell.2022.07.012 2022 Biology - Clinical
‘On the Spot’ Digital Pathology of Breast Cancer Based on Single-Cell Mass Spectrometry Imaging Cuypers, E.; Claes, B. S. R.; Biemans, R. et al. Analytical Chemistry, 94(16), 2022, 6180-6190 https://doi.org/10.1021/acs.analchem.1c05238 2022 Biology - Clinical
High Spatial Resolution MALDI Imaging Mass Spectrometry of Fresh-Frozen Bone Good, C. J.; Neumann, E. K.; Butrico, C. E. et al. Analytical Chemistry, 94(7), 3165-3172 https://doi.org/10.1021/acs.analchem.1c04604 2022 Biology
Simulation of the oxidative metabolization pattern of netupitant, a NK1 receptorantagonist, by electrochemistry coupled to mass spectrometry Chira, R.; Fangmeyer, J.; Neaga, I. O. et al. Journal of Pharmaceutical Analysis - in press, 2021 https://doi.org/10.1016/j.jpha.2021.03.011 2021 Chemistry – Basic Research
Retro Diels–Alder Fragmentation of Fulvene–Maleimide Bioconjugates for Mass Spectrometric Detection of Biomolecules Stevens, K. G.; McFarlene, L. O.; Platts, K. et al. Analytical Chemistry 93(36), 2021, 12204-12212 https://pubs.acs.org/doi/10.1021/acs.analchem.1c00193 2021 Chemistry – Basic Research
Removal of optimal cutting temperature (O.C.T.) compound from embedded tissue for MALDI imaging of lipids Truong, J. X. M.; Spotbeen, X.; White, J. et al. Analytical and Bioanalytical Chemistry 413, 2021, 2695-2708 https://doi.org/10.1007/s00216-020-03128-z 2021 Method Development
Rapid visualization of lipopeptides and potential bioactive groups of compounds by combining ion mobility and MALDI imaging mass spectrometry McCann, A.; Kune, C.; La Rocca, R. et al. Drug Discovery Today: Technologies - in press, 2021 https://doi.org/10.1016/j.ddtec.2021.08.003 2021 Chemistry – Basic Research
Protocol for multimodal analysis of human kidney tissue by imaging mass spectrometry and CODEX multiplexed immunofluorescence Neumann, E. K.; Patterson, N. H.; Allen, J. L. et al. STAR Protocols 2(3), 2021 100747 https://doi.org/10.1016/j.xpro.2021.100747 2021 Protocol
Poly(2-vinylpyridine) as a reference compound for mass calibration in positive-ion matrix-assisted laser desorption/ionization-mass spectrometry on different instrumental platforms Gross, J. H. European Journal of Mass Spectrometry 27(5), 2021, 191-204 https://doi.org/10.1177/14690667211055 2021 Method Development
Oxygen‐Doped PAH Electrochromes: Difurano, Dipyrano, and Furano‐Pyrano Containing Naphthalene‐Cored Molecules Fletcher-Charles, J.; Ferreira, R.R.; Abraham, M. et al. European Journal of Organic Chemistry, 2021 https://doi.org/10.1002/ejoc.202101166 2021 Chemistry – Basic Research
OpenTIMS, TimsPy, and TimsR: Open and Easy Access to timsTOF Raw Data Łącki, M. K.; Startek, M. P.; Brehmer, S. et al. Journal of Proteome Research 20, 2021, 2122-2129 https://doi.org/10.1021/acs.jproteome.0c00962 2021 Method Development
Microfluidic Electrochemistry Meets Trapped Ion Mobility Spectrometry and High-Resolution Mass Spectrometry—In Situ Generation, Separation, and Detection of Isomeric Conjugates of Paracetamol and Ethoxyquin Korzhenko, O.; Führer, P.; Göldner, V. et al. Analytical Chemistry 93(37), 2021, 12740-12747 https://pubs.acs.org/doi/10.1021/acs.analchem.1c02791 2021 Chemistry – Basic Research
Mass Spectrometry Imaging of Low-Molecular-Weight Phenols Liberated from Plastics Xu, Q.; Tian, R.; Lu, C. et al. Analytical Chemistry 93(40), 2021, 13703-13710 https://pubs.acs.org/doi/10.1021/acs.analchem.1c03397 2021 Chemistry – Basic Research
Evaluation of Therapeutic Collagen-Based Biomaterials in the Infarcted Mouse Heart by Extracellular Matrix Targeted MALDI Imaging Mass Spectrometry Clift, C. L.; McLaughlin, S.; Muñoz, M. et al. Journal of The American Society for Mass Spectrometry 32 (12), 2021, 2746-2754 https://pubs.acs.org/doi/10.1021/jasms.1c00189 2021 Biology - Clinical
Development of an electrochemical flow‐through cell for the fast and easy generation of isotopically labeled metabolite standards Göldner, V.; Fangmeyer, J.; Karst, U. Drug Testing and Analysis, 2021 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3175 2021 Chemistry – Basic Research
Detection and mapping of haemoglobin variants in blood fingermarks by MALDI MS for suspect “profiling”. Heaton, C.; Witt, M.; Cole, L. et al. Analyst 146, 2021, 4290 https://doi.org/10.1039/d1an00578b 2021 Chemistry – Basic Research
Complementing Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry Imaging with Chromatography Data for Improved Assignment of Isobaric and Isomeric Phospholipids Utilizing Trapped Ion Mobility-Mass Spectrometry Helmer, P. O.; Nordhorn, I. D.; Korf, A. et al. Analytical Chemistry 93, 2021, 2135-2143 https://doi.org/10.1021/acs.analchem.0c03942 2021 Chemistry – Basic Research
Automated Chiral Analysis of Amino Acids Based on Chiral Derivatization and Trapped Ion Mobility–Mass Spectrometry Will, J. M.; Behrens, A.; Macke, M. Analytical Chemistry 93(2), 2021, 878-885 https://doi.org/10.1021/acs.analchem.0c03481 2021 Chemistry – Basic Research
Automated Biomarker Candidate Discovery in Imaging Mass Spectrometry Data Through Spatially Localized Shapley Additive Explanations Tideman, L. E. M.; Migas, L. G.; Djambazova, K. V. et al. Analytica Chimica Acta 1177, 2021, 338522 https://doi.org/10.1016/j.aca.2021.338522 2021 Chemistry – Basic Research
Aliquoting of isobaric labeling reagents for low concentration and single cell proteomics samples Yuan, Y.; Orsburn, B. C. bioRxiv pre-print, 2021 https://doi.org/10.1101/2021.06.23.449560 2021 Chemistry – Basic Research
A TIMS-TOF mass spectrometry study of disaccharides from in-situ derivatization ESI with 3-pyridinylboronate Lia, L.; Yua, J.; Xiea, C. et al. Analyst 146, 2021, 75 https://doi.org/10.1039/D0AN01677B 2021 Chemistry – Basic Research
Absolute quantification of 2-hydroxyglutarate on tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging for rapid and precise identification of isocitrate dehydrogenase mutations in human glioma Chunyan, L.; Hainan, L.; Lei, W. et al. Rumeng Zhang, Xiaoai Yuan, Taihua Wu, Jie Wu, Ming Lu, Xu Ma Int. J. Cancer. 2021;1–8 https://doi: 10.1002/ijc.33729 2021 Biology - Clinical
Traumatic brain injury induces region-specific glutamate metabolism changes as measured by multiple mass spectrometry methods Sowers, J. L.; Sowers, M. L.; Shavkunov, A. S. et al. iScience 24(10), 2021, 103108 https://doi.org/10.1016/j.isci.2021.103108 2021 Biology - Clinical
Preserved and variable spatial-chemical changes of lipids across tomato leaves in response to central vein wounding reveals potential origin of linolenic acid in signal transduction cascade. Veličković, D.; Chu, R. K.; Henkel. C. et al. Journal of Plant-Environment Interactions 2(1), 2021, 28-35 https://doi.org/10.1002/pei3.10038 2021 Biology
Multiplexed imaging mass spectrometry of the extracellular matrix using serial enzyme digests from formalin-fixed paraffin-embedded tissue sections Clift, C. L.; Drake, R. R.; Mehta, A. et al. Analytical and Bioanalytical Chemistry 413, 2021, 2709-2719 https://doi.org/10.1007/s00216-020-03047-z 2021 Biology
Imaging Mass Spectrometry and Lectin Analysis of N-linked Glycans in Carbohydrate Antigen Defined Pancreatic Cancer Tissues McDowell, C. T.; Klamer, Z.; Hall, J. et al. Molecular & Cellular Proteomics 20, 2021, 100012 https://doi.org/10.1074/mcp.RA120.002256 2021 Biology - Clinical
Direct N-Glycosylation Profiling of Urine and Prostatic Fluid Glycoproteins and Extracellular Vesicles Blaschke, C. R. K.; Hartig, J. P.; Grimsley, G. et al. Frontiers in Chemistry 9, 2021, 734280 https://www.frontiersin.org/articles/10.3389/fchem.2021.734280/full 2021 Biology
CRL4AMBRA1 is a master regulator of D-type cyclins. Simoneschi, D.; Rona, G.; Zhou, N. et al. Nature 592, 2021, 789-793 https://doi.org/10.1038/s41586-021-03445-y 2021 Biology - Clinical
Complete spatial characterisation of N-glycosylation upon striatal neuroinflammation in the rodent brain. Rebelo, A. L.; Gubinelli, F.; Roost, P. et al. Journal of Neuroinflammation 18, 2021, Article number: 116 https://doi.org/10.1186/s12974-021-02163-6 2021 Biology
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH Dudek, M.; Pfister, D.; Donakonda, S. et al. Nature 592, 2021, 444-449 https://doi.org/10.1038/s41586-021-03233-8 2021 Biology - Clinical
Absolute Quantification of 2‐Hydroxyglutarate on Tissue by MALDI MSI for Rapid and Precise Identification of IDH Mutations in Human Glioma Lan, C.; Li, H.; Wang, L. et al. International Journal of Cancer, 2021 https://doi.org/10.1002/ijc.33729 2021 Biology - Clinical
β‑Cyclodextrin-poly (β-Amino Ester) Nanoparticles Are a Generalizable Strategy for High Loading and Sustained Release of HDAC Inhibitors Chaudhuri, S.; Fowler, M. J.; Baker, C. et al. Applied Materials & Interface 13, 2021, 20960-20973 https://doi.org/10.1021/acsami.0c22587 2021 Biology - Clinical
Rapid N-Glycan Profiling of Serum and Plasma by a Novel Slide-Based Imaging Mass Spectrometry Workflow Blaschke, C. R. K.; Black, A. P.; Mehta, A. S. et al. Journal of the American Society for Mass Spectrometry 31, 2020, 2511-2520 https://doi.org/10.1021/jasms.0c00213 2020 Chemistry – Basic Research
MS Imaging‐Guided Microproteomics for Spatial Omics on a Single Instrument Dewez, F.; Oetjen, J.; Henkel, C. et al. Proteomics 20, 2020, 1900369 https://doi.org/10.1002/pmic.201900369 2020 Chemistry – Basic Research
A mass spectrometry-based approach gives new insight into organotin–protein interactions Will, J. M.; Erbacher, C.; Sperling, M. et al. Metallomics 12(11), 2020, 1702-1712 https://doi.org/10.1039/d0mt00171f 2020 Chemistry – Basic Research
Spatial Metabolomics of the Human Kidney using MALDI Trapped Ion Mobility Imaging Mass Spectrometry. Neumann, E. K.;Migas, L. G.; Allen, J. L. et al. Analytical Chemistry 92(19), 2020, 13084-13091 https://doi.org/10.1021/acs.analchem.0c02051 2020 Biology
Resolving the Complexity of Spatial Lipidomics Using MALDI TIMS Imaging Mass Spectrometry Djambazova, K. V.; Klein, D. R.; Migas, L. G. et al. Analytical Chemistry 92(19), 2020, 13290-13297 https://doi.org/10.1021/acs.analchem.0c02520 2020 Biology
Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging Ščupáková,, K.; Dewez, F.; Walch, A. K. et al. Angewandte Chemie International Edition 59(40), 2020, 17447-17450 https://doi.org/10.1002/anie.202007315 2020 Biology - Clinical
Modulating Isoprenoid Biosynthesis Increases Lipooligosaccharides and Restores Acinetobacter baumannii Resistance to Host and Antibiotic Stress Palmer, L. D.; Minor, K. E.; Mettlach, J. A. et al. Cell Reports 32(10), 2020, 108129 https://doi.org/10.1016/j.celrep.2020.108129 2020 Biology - Clinical
Mass‐Spectrometric Imaging of Electrode Surfaces—a View on Electrochemical Side Reactions Fangmeyer, J.; Behrens, A.; Gleede, B. et al. Angewandte Chemie 132(46), 2020, 20608-20613 https://doi.org/10.1002/ange.202010134 2020 Chemistry – Basic Research
Lipidomic profiling of clinical prostate cancer reveals targetable alterations in membrane lipid composition Butler, L. M.; Mah, C. Y.; Machiels, J. et al. Cancer Research, 2020, 3863 https://doi.org/10.1158/0008-5472.CAN-20-3863 2020 Biology - Clinical
In situ isobaric lipid mapping by MALDI–ion mobility separation–mass spectrometry imaging Fu, T.; Oetjen, J.; Chapelle, M. et al. Journal of Mass Spectrometry 55(9), 2020, e4531 https://doi.org/10.1002/jms.4531 2020 Biology
Hydroperoxylated vs Dihydroxylated Lipids: Differentiation of Isomeric Cardiolipin Oxidation Products by Multidimensional Separation Techniques Helmer, P.O.; Behrens, A.; Rudt, E. et al. Analytical Chemistry 92(17), 2020, 12010-12016 https://doi.org/10.1021/acs.analchem.0c02605 2020 Biology
High-Performance Molecular Imaging with MALDI Trapped Ion-Mobility Time-of-Flight (timsTOF) Mass Spectrometry Spraggins, J. M.; Djambazova, K. V.; Rivera, E. S. et al. Analytical Chemistry 91(22), 2019, 14552-14560 https://doi.org/10.1021/acs.analchem.9b03612 2019 Chemistry – Basic Research
Detection of small molecule concentration gradients in ocular tissues and humours Boughton, B.A.; Thomas, O. R. B.; Demarais, N. J. et al. Journal of Mass Spectrometry 55(4), 2019, e4460 https://doi.org/10.1002/jms.4460 2019 Biology

timsTOF fleX MALDI-2

TITLE AUTHOR PUBLICATION LINK YEAR APPLICATION
Spatial Metabolomics and Lipidomics Reveal the Mechanisms of the Enhanced Growth of Breast Cancer Cell Spheroids Exposed to Triclosan Chen, J.; Xie, P.; Wu, P. et al. Environmental Science and Technology 6, 2023, 1, 509 https://doi.org/10.1021/acs.est.3c01746 2023 Biology - Clinical
Spatial lipidomics and metabolomics of multicellular tumor spheroids using MALDI-2 and trapped ion mobility imaging Chen, J.; Xie, P.; Dai, Qi. et al. Talanta 42, 2023, 4, 112368 https://doi.org/10.1016/j.talanta.2023.124795 2023 Biology - Clinical
Mass spectrometry imaging and single-cell transcriptional profiling reveal the tissue-specific regulation of bioactive ingredient biosynthesis in Taxus leaves Zhan, X.; Qiu, T.; Zhang, H. et al. Plant Communications 9, 2023, 1, eade8898 https://doi.org/10.1016/j.xplc.2023.100630 2023 Biology
Negative Ion-Mode N-Glycan Mass Spectrometry Imaging by MALDI-2-TOF-MS Soltwisch, J.; Heijs, B. Methods in Molecular Biology, 2023, 2023.01.03.522543 https://doi.org/10.1007/978-1-0716-3319-9_15 2023 Protocol
MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids Chen, J.; Xie, P.; Wu, P. et al. Chinese Chemical Letters 18, 2023, 6, e0287662 https://doi.org/10.1016/j.cclet.2023.108895 2023 Biology - Clinical
Cryo-ultramicrotomy and Mass Spectrometry Imaging Analysis of Nudibranch Microstructures Hamilton, B.R.; Chan, W.; Cheney, K. L. et al. J. Am. Soc. Mass Spectrom. 2022, 33, 3, 592–597 https://doi.org/10.1021/jasms.1c00254 2022 Biology
SETD2 deficiency promotes the transition from PKD to ccRCC by dysregulation of sphingomyelin metabolism Zhang, Y.; Liui, C.; Ye, T. et al. bioRxiv https://doi.org/10.1101/2022.11.10.515911 2022 Biology - Clinical
Three-Dimensional Mass Spectrometry Imaging Reveals Distributions of Lipids and the Drug Metabolite Associated with the Enhanced Growth of Colon Cancer Cell Spheroids Treated with Triclosan Xie, P.; Zhang, H.; Wu, P. et al. Analytical Chemistry, 94(40), 13667-13675 https://doi.org/10.1021/acs.analchem.2c00768 2022 Biology - Clinical
De novo phytosterol synthesis in animals Michellod, D.; Bien, T.; Birgel, D. et al. bioRxiv https://doi.org/10.1101/2022.04.22.489198 2022 Biology
Spatial Distribution of Isobaric Androgens in Target Tissues Using Chemical Derivatization and MALDI-2 on a Trapped Ion Mobility Quadrupole Time-of-Flight Instrument Mackay, C. L.; Soltwisch, J.; Heijs, B. et al. RSC Advances, 54, 2021 in-print https://doi.org/10.1039/d1ra06086d 2021 Biology - Clinical
Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI Andersen, M. K.; Høiem, T. S.; Claes, B. S. R. et al. Cancer & Metabolism 9, 2021, Article number: 9 https://doi.org/10.1186/s40170-021-00242-z 2021 Biology - Clinical
Molecular insights into symbiosis — mapping sterols in a marine flatworm-algae-system using high spatial resolution MALDI-2-MS imaging with ion mobility separation Bien, T; Hambleton, E. A; Dreisewerd, K. et al. Analytical and Bioanalytical Chemistry 413, 2021, 2767-2777 https://doi.org/10.1007/s00216-020-03070-0 2021 Biology
MALDI-2 on a Trapped Ion Mobility Quadrupole Time-of-Flight Instrument for Rapid Mass Spectrometry Imaging and Ion Mobility Separation of Complex Lipid Profiles Soltwisch, J.; Heijs, B.; Koch, A. et al. Analytical Chemistry 92, 2020, 8697-8703 https://doi.org/10.1021/acs.analchem.0c01747 2020 Chemistry – Basic Research
MALDI‑2 for the Enhanced Analysis of N‑Linked Glycans by Mass Spectrometry Imaging Heijs, B.; Potthoff, A.; Soltwisch, J. et al. Analytical Chemistry 92, 2020, 13904-13911 https://doi.org/10.1021/acs.analchem.0c02732 2020 Chemistry – Basic Research

 

For Research Use Only. Not for use in clinical diagnostic procedures.