timsTOF fleX Bibliography

timsTOF fleX Bibliography

The timsTOF fleX is a high performance UHR-OTOF system with integrated dual ESI/MALDI source, exhibiting high speed and robust MALDI Imaging. The additional trapped ion mobility feature adds another separation dimension to unravel complex data and make annotations in MALDI Images more reliable through CCS-matching. Since ASMS 2020 we switched to the next level to gain higher sensitivity for a broad range of compounds and equipped the instrument with a second laser allowing for postionization (MALDI-2).

MALDI-2 uses laser based postionization to enhance and enrich the MALDI experiment, providing access to chemical classes typically opaque to MALDI, at unprecedented sensitivity (2-3 orders of magnitude compared to traditional MALDI) Postionization significantly boosts ion yields for many different analytes and reduces the ever-challenging ion suppression effects in MALDI imaging.

The peer-reviewed and in-peer-reviewing communications listed below is a non-exhaustive list from the work initiated on the first timsTOF fleX (MALDI-2) instruments in the field in the years 2019-2023 and many more are to come.

timsTOF fleX

Advances in cellular and tissue-based imaging techniques for sarcoid granulomas Kim, J.; Dwivedi, G.; Boughton, B. A. et al. American Journal of Physiology-Cell Physiology, 326, 2024, 1, C10-C26 https://doi.org/10.1152/ajpcell.00507.2023 2024
Sodium doping and trapped ion mobility spectrometry improve lipid detection for novel MALDI-MSI analysis of oats Lau, W. C. D.; Donnellan, L.; Briggs, M. et al. Food Chemistry, 433, 2024, 137275 https://doi.org/10.1016/j.foodchem.2023.137275 2024
Use of tryptic peptide MALDI mass spectrometry imaging to identify the spatial proteomic landscape of colorectal cancer liver metastases. Li, C. M. Y.; Briggs, M.; Lee, Y. R. et al. medRxiv, 2024, preprint https://doi.org/10.1101/2024.01.24.24301748 2024
Competition for iron shapes metabolic antagonism between Bacillus subtilis and Pseudomonas marginalis Lyng, M.; Jørgensen, J. P. B.; Schostag, M. D. et al. The ISME Journal, 18, 2024, 1, wrad001 https://doi.org/10.1093/ismejo/wrad001 2024
Multimodal analytical tools for the molecular and elemental characterisation of lesions in brain tissue of multiple sclerosis patients Niehaus, P.; de Vega, R. G.; Haindl, M. T. et al. Talanta, 270, 2024, 125518 https://doi.org/10.1016/j.talanta.2023.125518 2024
Spatial Omics Reveals that Cancer-Associated Glycan Changes Occur Early in Liver Disease Development in a Western Diet Mouse Model of MASLD Ochoa-Rios, S.; Grauzam, S. E.; Gregory, R. et al. Journal of Proteome Research, 2024, 23, 2, 786–796 https://doi.org/10.1021/acs.jproteome.3c00672 2024
An N-glycome tissue atlas of 15 human normal and cancer tissue types determined by MALDI-imaging mass spectrometry Wallace, E. N.; West, C. A.; McDowell, C. T. et al. Scientific Reports, 14, 2024, 489 https://doi.org/10.1038/s41598-023-50957-w 2024
Spatial probabilistic mapping of metabolite ensembles in mass spectrometry imaging Abu Sammour, D.; Cairns, J. L.; Boskamp, T. et al. Nature Communications, 14, 2023, 1823 https://doi.org/10.1038/s41467-023-37394-z 2023
Unlocking the Hidden Depths: Multi-Modal Integration of Imaging Mass Spectrometry-Based and Molecular Imaging Techniques Akbari, B.; Huber, B. R.; Sherman, J. H. et al. Critical Reviews in Analytical Chemistry, 2023, 1-30 https://doi.org/10.1080/10408347.2023.2266838 2023
Sample Preparation Method for MALDI Mass Spectrometry Imaging of Fresh-Frozen Spines Bender, K. J; Wang, Y.; Zhai, C. Y. et al. Analytical Chemistry, 2023, 95, 47, 17337–17346 https://doi.org/10.1021/acs.analchem.3c03672 2023
Visualization of metabolites and microbes at high spatial resolution using MALDI mass spectrometry imaging and in situ fluorescence labeling Bourceau, P.; Geier, B.; Suerdieck, V. et al. Nature Protocols, 18, 2023, 3050–3079 https://doi.org/10.1038/s41596-023-00864-1 2023
Rewiring of the N-Glycome with prostate cancer progression and therapy resistance Butler, W.; McDowell, C.; Yang, Q. et al. NPJ Precision Oncology, 7, 2023, 22 https://doi.org/10.1038/s41698-023-00363-2 2023
MALDI TIMS IMS Reveals Ganglioside Molecular Diversity within Murine S. aureus Soft Tissue Abscesses. Djambazova, K. V.; Gibson-Corley, K. N.; Freiberg, J. A. et al. ChemRxiv, 2023, preprint https://doi:10.26434/chemrxiv-2023-whtvz 2023
Evaluation of antibody-based single cell type imaging techniques coupled to multiplexed imaging of N-glycans and collagen peptides by matrix-assisted laser desorption/ionization mass spectrometry imaging Dunne, J.; Griner, J.; Romeo, M. et al. Analytical and Bioanalytical Chemistry, 2023, 415, 7011–7024 https://doi.org/10.1007/s00216-023-04983-2 2023
A multiplexed single cell proteomic workflow applicable to drug treatment studies Eberhard, C. D.; Orsburn, B. C. OSF Preprints, 2023 https://doi.org/10.31219/osf.io/9nv5w 2023
Functional mass spectrometry imaging maps phospholipase-A2 enzyme activity during osteoarthritis progression Fan, X.; Young, R. S. E.; Sun, A. R. et al. Theranostics, 2023, 13(13): 4636–4649 https://doi.org/10.7150/thno.86623 2023
In situ lipidomics of Staphylococcus aureus osteomyelitis using imaging mass spectrometry Good, C. J.; Butrico, C. E.; Colley, M. E. et al. Biorxiv, 2023, 569690 https://doi.org/10.1101/2023.12.01.569690 2023
Deep MALDI-MS Spatial Omics guided by Quantum Cascade Laser Mid-infrared Imaging Microscopy Gruber, L.; Schmidt, S.; Enzlein, T. et al. bioRxiv, 2023, 571637 https://doi.org/10.1101/2023.12.14.571637 2023
On-tissue dataset-dependent MALDI-TIMS-MS2 bioimaging Heuckeroth, S.; Behrens, A.; Wolf, C. et al. Nature Communications, 14, 2023, 7495 https://doi.org/10.1038/s41467-023-43298-9 2023
Imaging mass spectrometry of isotopically-resolved intact proteins on a trapped ion-mobility quadrupole time-of-flight mass spectrometer Klein, D.; Rivera, E.; Caprioli, R. et al. ChemRxiv, 2023, preprint https://doi:10.26434/chemrxiv-2023-85m7b 2023
Ion Mobility Mass Spectrometry for the Separation and Characterization of Small Molecules Liu, L.; Wang, Z.; Zhang, Q. et al. Analytical Chemistry, 2023, 95, 1, 134–151 https://doi.org/10.1021/acs.analchem.2c02866 2023
Visualizing the Distribution of Jujube Metabolites at Different Maturity Stages Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Lu, D.; Wu, Y.; Zhang, J. et al. Foods, 12, 2023, 20, 3795 https://doi.org/10.3390/foods12203795 2023
Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19 Maeda, R.; Seki, N.; Uwamino, Y. et al. Nature Communications, 14, 2023, 1, 8469 https://doi.org/10.1038/s41467-023-44266-z 2023
A label-free approach for relative spatial quantitation of c-di-GMP in microbial biofilms McCaughey, C. S.; Trebino, M. A.; McAtamney, A. et al. bioRxiv, 2023, preprint https://doi.org/10.1101/2023.10.10.561783 2023
Spatial metabolomics principles and application to cancer research Planque, M.; Igelmann, S.; Campos, A. M. F. et al. Current Opinion in Chemical Biology, 76, 2023, 102362 https://doi.org/10.1016/j.cbpa.2023.102362 2023
Multi-omics data reveals aberrant gut microbiota-host glycerophospholipid metabolism in association with neuroinflammation in APP/PS1 mice Qian, X.; Hai, W.; Chen, S. et al. Gut Microbes, 15, 2023, 2, 2282790 https://doi.org/10.1080/19490976.2023.2282790 2023
SETD2 deficiency accelerates sphingomyelin accumulation and promotes the development of renal cancer Rao, H.; Liu, C.; Wang, A. et al. Nature Communications, 14, 2023, 7572 https://doi.org/10.1038/s41467-023-43378-w 2023
Rewiring of cortical glucose metabolism fuels human brain cancer growth Scott, A. J.; Mittal, A.; Meghdadi, B. et al. medRxiv, 2023, preprint https://doi.org/10.1101/2023.10.24.23297489 2023
A multimodal pipeline for image correction and registration of mass spectrometry imaging with microscopy Tang, W.; Li, Z.; Zou, Y, et al. Analytica Chimica Acta, 1283, 2023, 341969 https://doi.org/10.1016/j.aca.2023.341969 2023
Toward Omics-Scale Quantitative Mass Spectrometry Imaging of Lipids in Brain Tissue Using a Multiclass Internal Standard Mixture Vandenbosch, M.; Mutuku, S. M.; Mantas, M. J. Q. et al. Analytical Chemistry, 2023, 95, 51, 18719–18730 https://doi.org/10.1021/acs.analchem.3c02724 2023
Hepatic glutamine synthetase controls N 5-methylglutamine in homeostasis and cancer Villar, V. H.; Allega, M. F.; Deshmukh, R.; Ackermann, T. et al. Nature Chemical Biology, 19, 2023, 292–300 https://doi.org/10.1038/s41589-022-01154-9 2023
Metabolic Markers and Association of Biological Sex in Lupus Nephritis Wolf, B.; Blaschke, C. R. K; Mungaray, S. et al. International Journal of Molecular Sciences, 24, 2023, 22, 16490 https://doi.org/10.3390/ijms242216490 2023
Spatial Lipidomics Reveals Lipid Changes in the Cotyledon and Plumule of Mung Bean Seeds during Germination Xie, P.; Chen, J.; Wu, P. et al. Journal of Agricultural and Food Chemistry, 2023, 71, 49, 19879–19887 https://doi.org/10.1021/acs.jafc.3c06029 2023
Untargeted and spatial-resolved metabolomics characterize serum and tissue-specific metabolic reprogramming in acute kidney injury Xu, B.; Li, W.; Zhang, Y. et al. Heliyon, 9, 2023, 11 https://doi.org/10.1016/j.heliyon.2023.e21171 2023
The dentate gyrus differentially metabolizes glucose and alternative fuels during rest and stimulation York, E. M.; Miller, A.; Stopka, S. A. et al. Journal of Neurochemistry, 00, 2023, 1-22 https://doi.org/10.1111/jnc.16004 2023
Single-cell lipidomics enabled by dual-polarity ionization and ion mobility-mass spectrometry imaging Zhang, H.; Liu, Y.; Fields, L. et al. Nature Communications, 14, 2023, 5185 https://doi.org/10.1038/s41467-023-40512-6 2023
Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae Zhang, Y.; Gao, J.; Ma, L. et al. Nature Communications, 14, 2023, 875 https://doi.org/10.1038/s41467-023-36353-y 2023
Unveiling targeted spatial metabolome of rice seed at the dough stage using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry imaging Zhao, Y.; Hu, J.; Zhang, Y. et al. Food Research International, 174, 2023, 113578 https://doi.org/10.1016/j.foodres.2023.113578 2023
Pulmonary maternal immune activation does not extend through the placenta but leads to fetal metabolic adaptation Hansen, S. S. K.; Krautz, R.; Rago, D. et al. bioRxiv 14, 2023, 8, 492 https://doi.org/10.1101/2023.03.17.532052 2023 Biology - Clinical
The microenvironment dictates glycocalyx construction and immune surveillance Tharp, K.; Park, S.; Timblin, G. et al. Research Square 4, 2023, 08-04, 2023.07.28.551042 https://doi.org/10.21203/rs.3.rs-3164966/v1 2023 Biology - Clinical
GolpHCat (TMEM87A): a unique voltage-gated and pH-sensitive cation channel in the Golgi Kang, H.; Jeong, H.; Han, A. et al. bioRxiv, 2023, e2300680 https://doi.org/10.1101/2023.01.03.522543 2023 Biology
A super-resolution strategy for mass spectrometry imaging via transfer learning Liao, T.; Ren, Z.; Chai, Z. et al. Nature Machine Intelligence, 2023 https://doi.org/10.1038/s42256-023-00677-7 2023 Method Development
Enhanced niche colonisation and competition during bacterial adaptation to a fungus Richter, A.; Blei, F.; Hu, G. et al. bioRxiv, 2023 https://doi.org/10.1101/2023.03.27.534400 2023 Biology
Interpretable dimensionality reduction and classification of mass spectrometry imaging data in a visceral pain model via non-negative matrix factorization Pathirage, K.; Virmani, A.; Scott, A. J. et al. bioRxiv 22, 2023, 8, 2694-2702 https://doi.org/10.1101/2023.04.24.538180 2023 Method Development
Resistance towards and biotransformation of Pseudomonas-produced secondary metabolites during community invasion Hansen, M. L.; Dénes, Z.; Jarmusch, S. A. et al. bioRxiv 95, 2023, 28, 10603-10609 https://doi.org/10.1101/2023.06.20.545698 2023 Biology - Clinical
Investigating post-traumatic syringomyelia and local fluid osmoregulation via a rat model Pukale, D. D.; Adkins-Travis, K.; Aryal, S. R. et al. Research Square 76, 2023, 102362 https://doi.org/10.21203/rs.3.rs-3243600/v1 2023 Biology - Clinical
Fatty acids abrogate the growth-suppressive effects induced by inhibition of cholesterol flux in pancreatic cancer cells Li, Y.; Amrutkar, M.; Finstadsveen, A. V. et al. Research Square 43, 2023, 9, 1626-1635 https://doi.org/10.21203/rs.3.rs-3149861/v1 2023 Biology - Clinical
Unveiling the spatial metabolome and anti-atherosclerosis effects of Allium macrostemon Bunge and Allium chinense G. Don Li, S.; Lin, P.; Xing, H. et al. Arabian Journal of Chemistry 148, 2023, 13, 3002-3018 https://doi.org/10.1016/j.arabjc.2023.104772 2023 Biology - Clinical
ChIP-MS reveals the local chromatin composition by label-free quantitative proteomics Yong, W. K.; Rane, G.; Anuar, N. Z. et al. bioRxiv, 2023, 2023.06.23.546317 https://doi.org/10.1101/2023.01.27.525999 2023 Method Development
FluoMALDI microscopy: matrix co-crystallization simultaneously enhances fluorescence and MALDI imaging Yang, E.; Shen, X. E.; West-Foyle, H. et al. bioRxiv, 2023, 2023.06.20.545698 https://doi.org/10.1101/2023.05.27.542340 2023 Method Development
Omics Scale Quantitative Mass Spectrometry Imaging of Lipids in Brain Tissue using a Multi-Class Internal Standard Mixture Vandenbosch, M.; Mutuku, S. M.; Mantas, M. J. Q. et al. bioRxiv 14, 2023, 1, 3287 https://doi.org/10.1101/2023.06.21.546027 2023 Method Development
Cocaine Regulates Antiretroviral Therapy CNS Access Through Pregnane-X Receptor-Mediated Drug Transporter and Metabolizing Enzyme Modulation at the Blood Brain Barrier Fridman, L. B.; Knerler, S.; Price, A. et al. bioRxiv 24, 2023, 8, e56439 https://doi.org/10.1101/2023.07.28.551042 2023 Biology - Clinical
Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice Parhizkar, S.; Gent, G.; Chen, Y. et al. Science Translational Medicine, 2023 https://doi.org/10.1126/scitranslmed.ade6285 2023
3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib Meraz, I. M.; Majidi, M.; Fang, B. et al. Communications Biology 5, 2023, 6, 656-668 https://doi.org/10.1038/s42003-023-04889-w 2023 Biology - Clinical
Coordinated adaptations define the ontogenetic shift from worm- to fish-hunting in a venomous cone snail Rogalski, A.; Himaya, S. W. A.; Lewis, R. J. et al. Nature Communications, 2023 https://doi.org/10.1038/s41467-023-38924-5 2023 Biology
Reducing oxidative protein folding alleviates senescence by minimizing ER‐to‐nucleus H2O2 release Cheng, F.; Ji, Q.; Wang, L. et al. EMBO Reports 16, 2023, 6, 104772 https://doi.org/10.15252/embr.202256439 2023
Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis Gui, W.; Hole, M. J.; Molinaro, A. et al. Nature Communications, 2023, 100630 https://doi.org/10.1038/s41467-023-38840-8 2023 Biology - Clinical
Using mass spectrometry imaging to map fluxes quantitatively in the tumor ecosystem Schwaiger-Haber, M.; Stancliffe, E.; Anbukumar, D. S. et al. Nature Communications 14, 2023, 2876 https://doi.org/10.1038/s41467-023-38403-x 2023
Incorporating Anticoagulant and Antiplatelet Dual Functional Groups into Thermosetting Polymer Chain for Enhancing Antithrombogenicity Wang, W.; Liu, S.; Zhang, S. et al. Advanced Healthcare Materials, 2023 https://doi.org/10.1002/adhm.202300680 2023
Strategic self-limiting production of infectious HIV particles by CRISPR in permissive cells Liu, H.; Chen, C.; Liao, S. et al. Molecular Therapy - Nucleic Acids 14, 2023, 1, 2876 https://doi.org/10.1016/j.omtn.2023.04.027 2023 Biology
Strigolactones repress nodule development and senescence in pea Van Dingenen, J.; De Keyser, A.; Desmet, S. et al. The Plant Journal 32, 2023, 1010-1025 https://doi.org/10.1111/tpj.16421 2023 Biology
Photoreduction of Anthracenes Catalyzed by peri‐Xanthenoxanthene: a Scalable and Sustainable Birch‐type Alternative De Luca, C.; Zanetti, D.; Battisti, T. et al. Chemistry - A European Journal 12, 2023, Suppl 1, e12329 https://doi.org/10.1002/chem.202302129 2023 Chemistry – Basic Research
Integrated mass spectrometry imaging and single‐cell transcriptome atlas strategies provide novel insights into taxoid biosynthesis and transport in Taxus mairei stems Yu, C.; Hou, K.; Zhang, H. et al. The Plant Journal, 2023, 2023.05.13.540426 https://doi.org/10.1111/tpj.16315 2023 Biology
Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis Conroy, L. R.; Clarke, H. A.; Allison, D. B. et. al. Nature Communications 14, 2023, 1, 2759 https://doi.org/10.1038/s41467-023-38437-1 2023 Biology - Clinical
WSD-0922, a novel brain-penetrant inhibitor of epidermal growth factor receptor, promotes survival in glioblastoma mouse models Conage-Pough, J. E.; Stopka, S. A.; Oh, J. et al. Neuro-Oncology Advances 1265, 2023, 341267 https://doi.org/10.1093/noajnl/vdad066 2023 Biology - Clinical
Exposure to isocyanates predicts atopic dermatitis prevalence and disrupts therapeutic pathways in commensal bacteria Zeldin, J.; Chaudhary, P. P.; Spathies, J. et al. Science Advances 380, 2023, 6644, 520-526 https://doi.org/10.1126/sciadv.ade8898 2023 Biology - Clinical
Analysis of N-linked glycan alterations in tissue and serum reveals promising biomarkers for intrahepatic Cholangiocarcinoma Ochoa-Rios, S.; Blaschke, C. R. K.; Wang, M. et al. Cancer Research Communications 11, 2023, 1182404 https://doi.org/10.1158/2767-9764.crc-22-0422 2023 Biology - Clinical
Laser desorption/ionization-mass spectrometry for the analysis of interphases in lithium ion batteries Göldner, V.; Quach, L.; Adhitama, E. et al. iScience 95, 2023, 19, 7475-7486 https://doi.org/10.1016/j.isci.2023.107517 2023 Chemistry – Basic Research
Elucidation of the environmental reductive metabolism of the herbicide tritosulfuron assisted by electrochemistry and mass spectrometry Göldner, V.; Speitling, M.; Karst, U. Chemosphere 15, 2023, 693, eade6285 https://doi.org/10.1016/j.chemosphere.2023.138687 2023 Chemistry – Basic Research, Environmental, pollution
Macromolecular Engineering: From Precise Macromolecular Inks to 3D Printed Microstructures Catt, S. O.; Hackner, M.; Spatz, J. P. et al. Small, 2023, e2300844 https://doi.org/10.1002/smll.202300844 2023 Chemistry – Basic Research
Metabolomics of bacterial–fungal pairwise interactions reveal conserved molecular mechanisms Luu, G. T.; Little, J. C.; Pierce, E. C. et al. Analyst, 2023, 333-357 https://doi.org/10.1039/d3an00408b 2023 Biology
Direct mass spectrometric imaging of document handwriting with laser desorption ionization and post ultraviolet photodissociation Jia, S.; Zhou, X.; Hu, X. et al. Analytica Chimica Acta, 2023, 2023.03.27.534400 https://doi.org/10.1016/j.aca.2023.341267 2023 Chemistry – Basic Research, Forensic
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling Altea-Manzano, P.; Doglioni, G.; Liu, Y. et al. Nature Cancer 4, 2023, 03-29, 2023.03.23.533981 https://doi.org/10.1038/s43018-023-00513-2 2023
Bioorthogonal Chemical Labeling Probes Targeting Sialic Acid Isomers for N‑Glycan MALDI Imaging Mass Spectrometry of Tissues, Cells, and Biofluids Lu, X.; McDowell, C. T.; Blaschke, C. R. K. et al. Analytical Chemistry, 2023, 2023.03.17.532052 https://doi.org/10.1021/acs.analchem.2c04882 2023 Method Development
In vitro and ex vivo proteomics of Mycobacterium marinum biofilms and the development of biofilm-binding synthetic nanobodies Hammarén, M. M.; Luukinen, H.; Sillanpää, A. et al. mSystems, 2023 https://doi.org/10.1128/msystems.01073-22 2023 Biology - Clinical
Expression of transglutaminase 2 in human gut epithelial cells: Implications for coeliac disease Amundsen, S. F.; Stamnaes, J.; Lundin, K. E. A. et al. PLOS ONE 30, 2023, Suppl 1, 1-324 https://doi.org/10.1371/journal.pone.0287662 2023 Biology - Clinical
Towards optimised extracellular vesicle proteomics from cerebrospinal fluid Kangas, P.; Nyman, T. A.; Metsähonkala, L. et al. Scientific Reports 4, 2023, 03-29, 2023.03.13.532449 https://doi.org/10.1038/s41598-023-36706-z 2023 Biology, Method Development
Mobility-resolved broadband dissociation and parallel reaction monitoring for laser desorption/ionization-mass spectrometry - Tattoo pigment identification supported by trapped ion mobility spectrometry Wolf, C.; Behrens, A.; Brungs, C. et al. Analytica Chimica Acta 34, 2023, 4, 720-727 https://doi.org/10.1016/j.aca.2023.340796 2023 Method Development
Evaluating the Pharmacokinetics and Pharmacodynamics of Chemotherapeutics within a Spatial SILAC-Labeled Spheroid Model System Beller, N. C.; Wang, Y.; Hummon, A. B. Analytical Chemistry 3, 2023, 3, 383-394 https://doi.org/10.1021/acs.analchem.3c00905 2023 Biology - Clinical, Method Development
De novo phytosterol synthesis in animals Michellod, D.; Bien, T.; Birgel, D. et al. Science 7, 2023, 1, 22 https://doi.org/10.1126/science.add7830 2023
Microscopy-Directed Imaging Mass Spectrometry for Rapid High Spatial Resolution Molecular Imaging of Glomeruli Esselman, A. B.; Patterson, N. H.; Migas, L. G. et al. Journal of The American Society for Mass Spectrometry 42, 2023, 5, 1984-2206 https://doi.org/10.1021/jasms.3c00033 2023 Method Development
Analysis of single cells treated with the KRASG12D inhibitor MRTX 1133 reveals new challenges for the emerging field of single cell proteomics Orsburn, B. C. bioRxiv, 2023, 2023.02.20.529255 https://doi.org/10.1101/2023.03.23.533981 2023 Biology
High-Resolution N‑Glycan MALDI Mass Spectrometry Imaging of Subchondral Bone Tissue Microarrays in Patients with Knee Osteoarthritis Lee, Y.; Briggs, M. T.; Kuliwaba, J. S. et al. Analytical Chemistry 13, 2023, 1, 2776 https://doi.org/10.1021/acs.analchem.3c00348 2023 Biology - Clinical
Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation Li, M.; Wu, X.; Jing, W. et al. Cell Death & Disease 4, 2023, 3, 344-364 https://doi.org/10.1038/s41419-023-06017-2 2023 Biology - Clinical
Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation Miller, A.; York, E.; Stopka, S. et al. Research Square, 2023, 2023.01.27.525999 https://doi.org/10.21203/rs.3.rs-2276903/v1 2023 Biology - Clinical
Spatially Resolved Metabolites in Stable and Unstable Human Atherosclerotic Plaques Identified by Mass Spectrometry Imaging Seeley, E. H.; Liu, Z.; Yuan, S. et al. Arteriosclerosis Thrombosis and Vascular Biology 95, 2023, 4, 2329-2338 https://doi.org/10.1161/atvbaha.122.318684 2023 Biology - Clinical
Optimized protocol for MALDI MSI of N-glycans using an on-tissue digestion in fresh frozen tissue sections Grgic, A.; Krestensen, K. K.; Heeren, R. M. A. Scientific Reports 95, 2023, 1, 134-151 https://doi.org/10.1038/s41598-023-29560-6 2023 Protocol
Development of an Antibody-Based Platform for the Analysis of Immune Cell-Specific N‑linked Glycosylation Dressman, J. W.; McDowell, C. T.; Lu, X. et al. Analytical Chemistry 51, 2023, 3, dmd-mr-2022-001043 https://doi.org/10.1021/acs.analchem.3c00838 2023 Method Development
Complex-Type N‑Glycans Are Associated with Cartilage Degeneration within Different Loading Sites of the Tibial Plateau for Knee Osteoarthritis Patients Lee, Y.; Briggs, M. T.; Kuliwaba, J. S. et al. Journal of Proteome Research 1242, 2023, 340796 https://doi.org/10.1021/acs.jproteome.3c00251 2023 Biology - Clinical
MALDI HiPLEX-IHC: multiomic and multimodal imaging of targeted intact proteins in tissues Lim, M. J.; Yagnik, G.; Henkel, C. et al. Frontiers in Chemistry 43, 2023, 1, 28-29 https://doi.org/10.3389/fchem.2023.1182404 2023 Method Development
MALDI-IHC-Guided In-Depth Spatial Proteomics: Targeted and Untargeted MSI Combined Claes, B. S. R.; Krestensen, K. K.; Yagnik, G. et al. Analytical Chemistry 5, 2023, 1, vdad066 https://doi.org/10.1021/acs.analchem.2c04220 2023 Biology, Method Development
Visualization of Differential Cardiolipin Profiles in Murine Retinal Cell Layers by High-Resolution MALDI Mass Spectrometry Imaging Bessler, S.; Soltwisch, J.; Dreisewerd, K. Analytical Chemistry 2670, 2023 https://doi.org/10.1021/acs.analchem.3c01465 2023 Biology
Enhancement of Lipid Signals in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry with Ammonium Fluoride as a Matrix Additive Holbrook, J. H.; Sekera, E. R.; Lopez, A. et al. Analytical Chemistry 119, 2023 https://doi.org/10.1021/acs.analchem.3c00753 2023 Method Development
A Multimodal SIMS/MALDI Mass Spectrometry Imaging Source with Secondary Electron Imaging Capabilities for Use with timsTOF Instruments Krijnen, K.; Keelor, J. D.; Böhm, S. et al. Journal of The American Society for Mass Spectrometry 2688, 2023 https://doi.org/10.1021/jasms.2c00381 2023 Method Development
HOMO Energy-Level Lifting in p-Type O-Doped Graphenoids: Synthesis of Electrochromic Alkoxy-Decorated Xanthenoxanthenes Rossignon, A.; Berna, B. B.; Parola, A. J. et al. Organic Materials, 4(04), 240-254 https://doi.org/10.1055/a-1976-0291 2022 Chemistry – Basic Research
Applying imaging mass spectrometry to define the N-glycan profiles of co-localized virus and immune cell infiltrates in post-COVID-19 infected lung autopsy tissues Jones,E. E.; Drake, R. R.; Dressman, J. W. et al. Frontiers in Analytical Science, 2, 1021008 https://doi.org/10.3389/frans.2022.1021008 2022 Biology - Clinical
Deep topographic proteomics of a human brain tumour Davis, S.; Scott, C.; Oetjen, J. et al. bioRxiv https://doi.org/10.1101/2022.03.21.485119 2022 Biology
Single Cell Proteomics Using a Trapped Ion Mobility Time-of-Flight Mass Spectrometer Provides Insight into the Post-translational Modification Landscape of Individual Human Cells Orsburn, B. C.; Yuan, Y.; Bumpus, N. bioRxiv https://doi.org/10.1101/2022.02.12.480144 2022 Biology
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Visualizing the Distribution of Lipids in Peanut Seeds by MALDI Mass Spectrometric Imaging Wang, X., Chen, Y., Liu, Y. et al. Foods, 11(23), 3888 https://doi.org/10.3390/foods11233888 2022 Biology
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Microfluidic Electrochemistry Meets Trapped Ion Mobility Spectrometry and High-Resolution Mass Spectrometry—In Situ Generation, Separation, and Detection of Isomeric Conjugates of Paracetamol and Ethoxyquin Korzhenko, O.; Führer, P.; Göldner, V. et al. Analytical Chemistry 93(37), 2021, 12740-12747 https://pubs.acs.org/doi/10.1021/acs.analchem.1c02791 2021 Chemistry – Basic Research
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Imaging Mass Spectrometry and Lectin Analysis of N-linked Glycans in Carbohydrate Antigen Defined Pancreatic Cancer Tissues McDowell, C. T.; Klamer, Z.; Hall, J. et al. Molecular & Cellular Proteomics 20, 2021, 100012 https://doi.org/10.1074/mcp.RA120.002256 2021 Biology - Clinical
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Spatial Metabolomics of the Human Kidney using MALDI Trapped Ion Mobility Imaging Mass Spectrometry. Neumann, E. K.;Migas, L. G.; Allen, J. L. et al. Analytical Chemistry 92(19), 2020, 13084-13091 https://doi.org/10.1021/acs.analchem.0c02051 2020 Biology
Resolving the Complexity of Spatial Lipidomics Using MALDI TIMS Imaging Mass Spectrometry Djambazova, K. V.; Klein, D. R.; Migas, L. G. et al. Analytical Chemistry 92(19), 2020, 13290-13297 https://doi.org/10.1021/acs.analchem.0c02520 2020 Biology
Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging Ščupáková,, K.; Dewez, F.; Walch, A. K. et al. Angewandte Chemie International Edition 59(40), 2020, 17447-17450 https://doi.org/10.1002/anie.202007315 2020 Biology - Clinical
Modulating Isoprenoid Biosynthesis Increases Lipooligosaccharides and Restores Acinetobacter baumannii Resistance to Host and Antibiotic Stress Palmer, L. D.; Minor, K. E.; Mettlach, J. A. et al. Cell Reports 32(10), 2020, 108129 https://doi.org/10.1016/j.celrep.2020.108129 2020 Biology - Clinical
Mass‐Spectrometric Imaging of Electrode Surfaces—a View on Electrochemical Side Reactions Fangmeyer, J.; Behrens, A.; Gleede, B. et al. Angewandte Chemie 132(46), 2020, 20608-20613 https://doi.org/10.1002/ange.202010134 2020 Chemistry – Basic Research
Lipidomic profiling of clinical prostate cancer reveals targetable alterations in membrane lipid composition Butler, L. M.; Mah, C. Y.; Machiels, J. et al. Cancer Research, 2020, 3863 https://doi.org/10.1158/0008-5472.CAN-20-3863 2020 Biology - Clinical
In situ isobaric lipid mapping by MALDI–ion mobility separation–mass spectrometry imaging Fu, T.; Oetjen, J.; Chapelle, M. et al. Journal of Mass Spectrometry 55(9), 2020, e4531 https://doi.org/10.1002/jms.4531 2020 Biology
Hydroperoxylated vs Dihydroxylated Lipids: Differentiation of Isomeric Cardiolipin Oxidation Products by Multidimensional Separation Techniques Helmer, P.O.; Behrens, A.; Rudt, E. et al. Analytical Chemistry 92(17), 2020, 12010-12016 https://doi.org/10.1021/acs.analchem.0c02605 2020 Biology
High-Performance Molecular Imaging with MALDI Trapped Ion-Mobility Time-of-Flight (timsTOF) Mass Spectrometry Spraggins, J. M.; Djambazova, K. V.; Rivera, E. S. et al. Analytical Chemistry 91(22), 2019, 14552-14560 https://doi.org/10.1021/acs.analchem.9b03612 2019 Chemistry – Basic Research
Detection of small molecule concentration gradients in ocular tissues and humours Boughton, B.A.; Thomas, O. R. B.; Demarais, N. J. et al. Journal of Mass Spectrometry 55(4), 2019, e4460 https://doi.org/10.1002/jms.4460 2019 Biology

timsTOF fleX MALDI-2

De novo phytosterol synthesis in animals Michellod, D.; Bien, T.; Birgel, D. et al. Science, 2023, 380, 6644, 520-526 https://doi.org/10.1126/science.add7830 2023
MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids Chen, J.; Xie, P.; Wu, P. et al. Chinese Chemical Letters, 2023, 108895 https://doi.org/10.1016/j.cclet.2023.108895 2023
Spatial lipidomics and metabolomics of multicellular tumor spheroids using MALDI-2 and trapped ion mobility imaging Chen, J.; Xie, P.; Dai, Q. et al. Talanta, 2023, 124795 https://doi.org/10.1016/j.talanta.2023.124795 2023
Spatial Metabolomics and Lipidomics Reveal the Mechanisms of the Enhanced Growth of Breast Cancer Cell Spheroids Exposed to Triclosan Chen, Jing; Xie, Peisi; Wu, Pengfei; Lin, Zian; He, Yu; Cai, Zongwei Environmental Science and Technology 6, 2023, 1, 509 https://doi.org/10.1021/acs.est.3c01746 2023 Biology - Clinical
Mass spectrometry imaging and single-cell transcriptional profiling reveal the tissue-specific regulation of bioactive ingredient biosynthesis in Taxus leaves Zhan, Xiaori; Qiu, Tian; Zhang, Hongshan; Hou, Kailin; Liang, Xueshuang; Chen, Cheng; Wang, Zhijing; Wu, Qicong; Wang, Xiaojia; Li, Xiao-Lin; Wang, Mingshuang; Feng, Shangguo; Zeng, Houqing; Yu, Chunna; Wang, Huizhong; Shen, Chenjia Plant Communications 9, 2023, 1, eade8898 https://doi.org/10.1016/j.xplc.2023.100630 2023 Biology
Negative Ion-Mode N-Glycan Mass Spectrometry Imaging by MALDI-2-TOF-MS Soltwisch, Jens; Heijs, Bram Methods in Molecular Biology, 2023, 2023.01.03.522543 https://doi.org/10.1007/978-1-0716-3319-9_15 2023 Protocol
Cryo-ultramicrotomy and Mass Spectrometry Imaging Analysis of Nudibranch Microstructures Hamilton, B.R.; Chan, W.; Cheney, K. L.; Sullivan, R.K.P.; Floetenmeyer, M.; Garson, M. J.; Wepf, R. J. Am. Soc. Mass Spectrom. 2022, 33, 3, 592–597 https://doi.org/10.1021/jasms.1c00254 2022 Biology
SETD2 deficiency promotes the transition from PKD to ccRCC by dysregulation of sphingomyelin metabolism Zhang, Y., Liui, Changwei, Ye, T. et. al. bioRxiv https://doi.org/10.1101/2022.11.10.515911 2022 Biology - Clinical
Three-Dimensional Mass Spectrometry Imaging Reveals Distributions of Lipids and the Drug Metabolite Associated with the Enhanced Growth of Colon Cancer Cell Spheroids Treated with Triclosan Xie, P., Zhang, H., Wu, P. et. al. Analytical Chemistry, 94(40), 13667-13675 https://doi.org/10.1021/acs.analchem.2c00768 2022 Biology - Clinical
Spatial Distribution of Isobaric Androgens in Target Tissues Using Chemical Derivatization and MALDI-2 on a Trapped Ion Mobility Quadrupole Time-of-Flight Instrument Mackay, C. L.; Soltwisch, J.; Heijs, B.; Smith, K. W.; Cruickshank, F. L.; Nyhuis, A.; Dreisewerd, K.; Cobice, D. RSC Advances, 54, 2021 in-print https://doi.org/10.1039/d1ra06086d 2021 Biology - Clinical
Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI Andersen, M. K.; Høiem, T. S.; Claes, B. S. R. et al. Cancer & Metabolism 9, 2021, Article number: 9 https://doi.org/10.1186/s40170-021-00242-z 2021 Biology - Clinical
Molecular insights into symbiosis — mapping sterols in a marine flatworm-algae-system using high spatial resolution MALDI-2-MS imaging with ion mobility separation Bien, T; Hambleton, E. A; Dreisewerd, K. et al. Analytical and Bioanalytical Chemistry 413, 2021, 2767-2777 https://doi.org/10.1007/s00216-020-03070-0 2021 Biology
MALDI-2 on a Trapped Ion Mobility Quadrupole Time-of-Flight Instrument for Rapid Mass Spectrometry Imaging and Ion Mobility Separation of Complex Lipid Profiles Soltwisch, J.; Heijs, B.; Koch, A. et. al Analytical Chemistry 92, 2020, 8697-8703 https://doi.org/10.1021/acs.analchem.0c01747 2020 Chemistry – Basic Research
MALDI‑2 for the Enhanced Analysis of N‑Linked Glycans by Mass Spectrometry Imaging Heijs, B.; Potthoff, A.; Soltwisch, J. et al. Analytical Chemistry 92, 2020, 13904-13911 https://doi.org/10.1021/acs.analchem.0c02732 2020 Chemistry – Basic Research


For Research Use Only. Not for use in clinical diagnostic procedures.