timsTOF fleX Bibliography
timsTOF fleX Bibliography
The timsTOF fleX is a high performance UHR-OTOF system with integrated dual ESI/MALDI source, exhibiting high speed and robust MALDI Imaging. The additional trapped ion mobility feature adds another separation dimension to unravel complex data and make annotations in MALDI Images more reliable through CCS-matching. Since ASMS 2020 we switched to the next level to gain higher sensitivity for a broad range of compounds and equipped the instrument with a second laser allowing for postionization (MALDI-2).
MALDI-2 uses laser based postionization to enhance and enrich the MALDI experiment, providing access to chemical classes typically opaque to MALDI, at unprecedented sensitivity (2-3 orders of magnitude compared to traditional MALDI) Postionization significantly boosts ion yields for many different analytes and reduces the ever-challenging ion suppression effects in MALDI Imaging.
The peer-reviewed and in-peer-reviewing communications listed below is a non-exhaustive list from the work initiated on the first timsTOF fleX (MALDI-2) instruments in the field in the years 2019-2025 and many more are to come.
timsTOF fleX
| TITLE | AUTHOR | PUBLICATION | LINK | YEAR | APPLICATION |
|---|---|---|---|---|---|
| Spatial Proteomics by Parallel Accumulation‐Serial Fragmentation Supported MALDI MS/MS Imaging: A First Glance Into Multiplexed and Spatial Peptide Identification | Li, M. J.; Meyer, L. C.; Meier, N. et al. | Rapid Communications in Mass Spectrometry, 39, 9, e10006 | https://doi.org/10.1002/rcm.10006 | 2025 | |
| Visualization and Spatial Mapping of PFAS in the Edible Storage Root of Radish | Zuo, Y.; Zhang, W. | Journal of Hazardous Materials Letters, 6, 100141 | https://doi.org/10.1016/j.hazl.2025.100141 | 2025 | |
| Mass‐Guided Single‐Cell MALDI Imaging of Low‐Mass Metabolites Reveals Cellular Activation Markers | Cairns, J. L.; Huber, J.; Lewen, A. et al. | Advanced Science, 12, 5, 2410506 | https://doi.org/10.1002/advs.202410506 | 2025 | |
| Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues | Lee, Y.; Kaya, I.; Wik, E. et al. | Analytical Chemistry, 97, 2, 1338-1346 | https://doi.org/10.1021/acs.analchem.4c05665 | 2025 | |
| Advancing Atherosclerosis Research: The Power of Lipid Imaging with MALDI-MSI | Bookmeyer, C. HM; Blanchar, F X. C.; Masana, L. et al. | Atherosclerosis, 119130, in press | https://doi.org/10.1016/j.atherosclerosis.2025.119130 | 2025 | |
| The spatiotemporal changes of metabolites in Pinellia ternata at different development stages by MALDI‐MSI | Pei, Y.; Feng, X.; Liu, Z. et al. | Physiologia Plantarum, 177, 1, e70049 | https://doi.org/10.1111/ppl.70049 | 2025 | |
| Metabolic Atlas of Human Eyelid Infiltrative Basal Cell Carcinoma | Huang, Y.; He, C.; Hu, Q. et al. | Investigative Ophthalmology & Visual Science, 66, 1, 11 | https://doi.org/10.1167/iovs.66.1.11 | 2025 | |
| Environmental exposure to common pesticide induces synaptic deficit and social memory impairment driven by neurodevelopmental vulnerability of hippocampal parvalbumin interneurons | Di Re, J.; Koff, L.; Avchalumov, Y. et al. | Journal of Hazardous Materials, 485, 136893 | https://doi.org/10.1016/j.jhazmat.2024.136893 | 2025 | |
| Impact of aerobic exercise on brain metabolism: Insights from spatial metabolomic analysis | Zheng, J.; Luo, W.; Kong, C. et al. | Behavioural Brain Research, 478, 115339 | https://doi.org/10.1016/j.bbr.2024.115339 | 2025 | |
| A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment | Zhu, B.; Bai, Y.; Yeo, Y. et al. | Nature Communications, 16, 1, 1230 | https://doi.org/10.1038/s41467-025-56237-7 | 2025 | |
| The structure of Shigella virus Sf14 reveals the presence of two decoration proteins and two long tail fibers | Subramanian, S.; Kerns, H. R.; Braverman, S. G. et al. | Communications Biology, 8, 1, 222 | https://doi.org/10.1038/s42003-025-07668-x | 2025 | |
| Mass Spectrometry Imaging in Diagnostic and Toxicologic Pathology for Label-Free Detection of Molecules—From Basics to Practical Applications | Vezzali, E.; Becker, M.; Romero-Palomo, F. et al. | Toxicologic Pathology, in press | https://doi.org/10.1177/01926233241311269 | 2025 | |
| Mass Spectrometry-Based Spatial Multiomics Revealed Bioaccumulation Preference and Region-Specific Responses of PFOS in Mice Cardiac Tissue | Shi, R.; Chen, Y.; Wu, W. et al. | Environmental Science & Technology, 59, 4, 1957-1968 | https://doi.org/10.1021/acs.est.4c09874 | 2025 | |
| Spatiotemporal landscape of kidney in a mouse model of hyperuricemia at single‐cell level | Chang, H.; Tao, Q.; Wei, L. et al. | The FASEB Journal, 39, 2, e70292 | https://doi.org/10.1096/fj.202401801RR | 2025 | |
| Resolving tissue complexity by multimodal spatial omics modeling with MISO | Coleman, K.; Schroeder, A.; Loth, M. et al. | Nature methods, 1-9 | https://doi.org/10.1038/s41592-024-02574-2 | 2025 | |
| Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2 | Rasmussen, C. L. M.; Frederiksen, S. F.; Heegaard, C. W. et al. | Fluids and Barriers of the CNS, 22, 1, 13 | https://doi.org/10.1186/s12987-025-00621-4 | 2025 | |
| Tigulixostat Alleviates Hyperuricemic Nephropathy by Promoting M2 Macrophage Polarization | Xue, L.; Tao, Q.; Chang, H. et al. | Journal of Inflammation Research, 18, 17-30 | https://doi.org/10.2147/JIR.S500101 | 2025 | |
| Subtilosin A production is influenced by surfactin levels in Bacillus subtilis | Dinesen, C.; Vertot, M.; Jarmusch, S. A. et al. | Microlife, 6, uqae029 | https://doi.org/10.1093/femsml/uqae029 | 2025 | |
| Study of association between embryo growth arrest (EGA) and atmospheric fine particulate matter pollution (PM2. 5) and spatial metabolomics of villi derived from pregnant women | Bai, L.; Fu, P.; Dong, C. et al. | Journal of Hazardous Materials, 485, 136833 | https://doi.org/10.1016/j.jhazmat.2024.136833 | 2025 | |
| Sequential MALDI-HiPLEX-IHC and Untargeted Spatial Proteomics Mass Spectrometry Imaging to Detect Proteomic Alterations Associated with Tumour Infiltrating Lymphocytes | Bindi, G.; Monza, N.; de Oliveira, G. S. et al. | Journal of Proteome Research, 24, 2, 871-880 | https://doi.org/10.1021/acs.jproteome.4c00914 | 2025 | |
| Insight into distribution and composition of nonhuman N-Glycans in mammalian organs via MALDI-TOF and MALDI-MSI | Guo, R.; Heijs, B.; Wang, W. et al. | Carbohydrate Polymers, 351, 123065 | https://doi.org/10.1016/j.carbpol.2024.123065 | 2025 | |
| Visualizing the spatial distribution of metabolites in tomato fruit at different maturity stages by matrix-assisted laser desorption/ionization mass spectrometry imaging | Sihui, G.; Chaochao, L.; Zhuping, Y. et al. | Food Research International, 206, 115973 | https://doi.org/10.1016/j.foodres.2025.115973 | 2025 | |
| Comprehensive MALDI mass spectrometry imaging of tumor regions post-neoadjuvant therapy | Xu, H.; Zhang, Q.; Yuan, J. et al. | Anal Bioanal Chem 417, 2039–2046 | https://doi.org/10.1007/s00216-025-05785-4 | 2025 | |
| Coupling proteomics and lipidomics for insights into regulation of oat (Avena sativa) grain lipid synthesis | Wai, C. D. L.; Leigh, D.; John, C. H. et al. | Food Chemistry, 478, 143644 | https://doi.org/10.1016/j.foodchem.2025.143644 | 2025 | |
| N-linked fucosylated glycans are biomarkers for prostate cancer with a neuroendocrine and metastatic phenotype | Ippolito, J. E.; Hartig, J. P.; Bejar, K. et al. | Molecular Cancer Research, 23, 1, 59-70 | https://doi.org/10.1158/1541-7786.MCR-24-0660 | 2025 | |
| An Updated Guide to the Identification, Quantitation, and Imaging of the Crustacean Neuropeptidome | Wu, W.; Fields, L.; DeLaney, K. et al. | Peptidomics: Methods and Strategies, 255-289 | https://doi.org/10.1007/978-1-0716-3646-6_14 | 2024 | |
| 6-Aza-2-Thiothymine as an Alternative Matrix for Spatial Proteomics with MALDI-MSI | Denti, V.; Monza, N.; Bindi, G. et al. | International Journal of Molecular Sciences, 25, 24, 13678 | https://doi.org/10.3390/ijms252413678 | 2024 | |
| The spatial distribution of components in Moringa oleifera (Lam) seed by matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) | Wang, T.; Wang, J.; Yang, S. et al. | International Journal of Mass Spectrometry, 504, 117287 | https://doi.org/10.1016/j.ijms.2024.117287 | 2024 | |
| Quantitative MALDI-MS and Imaging of Fungicide Pyrimethanil in Strawberries with 2-Nitrophloroglucinol as an Effective Matrix | McDonald, H.; Li, Q.; Ashaduzzaman, M. et al. | Journal of the American Society for Mass Spectrometry, 35, 6, 1272-1281 | https://doi.org/10.1021/jasms.4c00066 | 2024 | |
| Accumulation of Bioactive Lipid Species in LPS-Induced Neuroinflammation Models Analysed with Multi-Modal Mass Spectrometry Imaging | Razo, I. B.; Shea, K.; Allen, T. et al. | International Journal of Molecular Sciences, 25, 22, 12032 | https://doi.org/10.3390/ijms252212032 | 2024 | |
| Analyzing noncovalent interactions between notoginseng saponins and lysozyme by deposition scanning intensity fading MALDI‐TOF mass spectrometry | Zhao, X.; Ren, J.; Wang, Z. et al. | Journal of Mass Spectrometry, 59, 7, e5058 | https://doi.org/10.1002/jms.5058 | 2024 | |
| Matrix-assisted laser desorption/ionization mass spectrometry imaging for quorum sensing | Kuik, C.; van Hoogstraten, S. WG.; Arts, J. JC. et al. | AMB Express, 14,1, 45 | https://doi.org/10.1186/s13568-024-01703-6 | 2024 | |
| Spatial metabolomics to discover hypertrophic scar relevant metabolic alterations and potential therapeutic strategies: A preliminary study | Li, J.; Zeng, S.; Zhang, E. et al. | Bioorganic Chemistry, 153, 107873 | https://doi.org/10.1016/j.bioorg.2024.107873 | 2024 | |
| Spatial resolution of renal amyloid deposits through MALDI-MSI: a combined digital and molecular approach to monoclonal gammopathies | Bindi, G.; Smith, A.; Oliveira, G. et al. | Journal of Clinical Pathology, 77, 6, 402-410 | https://doi.org/10.1136/jcp-2023-208790 | 2024 | |
| Nitro Indole Derivatives as Novel Dual-Polarity Matrices for MALDI Mass Spectrometry and Imaging with Broad Applications | Liang, Q.; Mondal, P.; Li, Q. et al. | Analytical Chemistry, 96, 4, 1668-1677 | https://doi.org/10.1021/acs.analchem.3c04684 | 2024 | |
| Unveiling the spatial distribution of plant defense metabolites in Dracaena cambodiana Pierre ex Gagnep under wound stress | Zhang, Y.; Liu, Y.; Wang, B. et al. | Industrial Crops and Products, 222, 15, 119941 | https://doi.org/10.1016/j.indcrop.2024.119941 | 2024 | |
| TET3 regulates terminal cell differentiation at the metabolic level | Mulet, I.; Grueso-Cortina, C.; Cortés-Cano, M. et al. | Nature communications, 15, 1, 9749 | https://doi.org/10.1038/s41467-024-54044-0 | 2024 | |
| Long-term exposure to triclocarban induces splenic injuries in mice: Insights from spatial metabolomics and lipidomics | Xie, P.; Chen, J.; Dan, A. et al. | Journal of Hazardous Materials, 480, 136370 | https://doi.org/10.1016/j.jhazmat.2024.136370 | 2024 | |
| Processing Next-Generation Mass Spectrometry Imaging Data: Principal Component Analysis at Scale | Krijnen, K.; Blenkinsopp, P.; Heeren, R. MA. Et al. | Journal of the American Society for Mass Spectrometry, 35, 12, 3063-3069 | https://doi.org/10.1021/jasms.4c00314 | 2024 | |
| Mass Spectrometry Imaging Distinguishes Biliary Toxicants on the Basis of Cellular Distribution | Yang, J.; Bowman, A. P.; Buck, W. R. et al. | Toxicologic Pathology, 53, 1, 55-64 | https://doi.org/10.1177/01926233241303890 | 2024 | |
| Mass Spectrometry Imaging for Spatial Ingredient Classification in Plant-Based Food | Vats, M.; Flinders, B.; Visvikis, T. et al. | Journal of the American Society for Mass Spectrometry, 36, 1, 100-107 | https://doi.org/10.1021/jasms.4c00353 | 2024 | |
| Spatial omics-based machine learning algorithms for the early detection of hepatocellular carcinoma | Wang, M.; Grauzam, S.; Bayram, M. F. et al. | Communications Medicine, 4, 1, 1-11 | https://doi.org/10.1038/s43856-024-00677-7 | 2024 | |
| Sphingolipid Levels and Processing of the Retinyl Chromophore in the Retina of a Mouse Model of Niemann-Pick Disease | Rahman, B.; Anderson, D. MG; Chen, C. et al. | Investigative ophthalmology & visual science, 65, 14, 24 | https://doi.org/10.1167/iovs.65.14.24 | 2024 | |
| Multiplexed and Multiomic Mass Spectrometry Imaging of MALDI-IHC Photocleavable Mass Tag Tissue Probes, N-Glycomics, and the Extracellular Matrisome from FFPE Tissue Sections | Taylor, H. B.; Dunne, J. B.; Lim, M. J. et al. | Tissue Proteomics: Methods and Protocols, 305-332 | https://doi.org/10.1007/978-1-0716-4298-6_19 | 2024 | |
| Unlocking the Secrets of Insects: The Role of Mass Spectrometry to Understand the Life of Insects | Mayorga‐Martino, V.; Mansurova, M.; Calla‐Quispe, E. et al. | Mass Spectrometry Reviews | https://doi.org/10.1002/mas.21922 | 2024 | |
| Unveiling a CAAX Protease‐Like Protein Involved in Didemnin Drug Maturation and Secretion | Zou, X.; Hui, Z.; Shepherd, R. A. et al. | Advanced Science, 11, 4, 2306044 | https://doi.org/10.1002/advs.202306044 | 2024 | |
| High‐Throughput Miniaturized Synthesis of PROTAC‐Like Molecules | Tian, Y.; Seifermann, M.; Bauer, L. et al. | Small, 20, 26, 2307215 | https://doi.org/10.1002/smll.202307215 | 2024 | |
| Mass Spectrometry Imaging with Trapped Ion Mobility Spectrometry Enables Spatially Resolved Chondroitin, Dermatan, and Hyaluronan Glycosaminoglycan Oligosaccharide Analysis In Situ | Devlin, A.; Green, F.; Takats, Z. | Analytical Chemistry, 96, 45, 17969-17977 | https://doi.org/10.1021/acs.analchem.4c02706 | 2024 | |
| Tracking Drugs and Lipids: Quantitative Mass Spectrometry Imaging of Liposomal Doxorubicin Delivery and Bilayer Fate in Three-Dimensional Tumor Models | Lopez, A.; Holbrook, J. H.; Kemper, G. E. et al. | Analytical Chemistry, 96, 22, 9254-9261 | https://doi.org/10.1021/acs.analchem.4c01586 | 2024 | |
| Spatial and widely targeted metabolomics and anatomical analysis reveal the mechanisms associated with petal bicolor patterning of two Dendrobium species | Ou, M.; Li, H.; Liang, H. et al. | Brazilian Journal of Botany, 47, 2, 367-380 | https://doi.org/10.1007/s40415-024-01002-1 | 2024 | |
| Spatially Resolved Molecular Characterization of Noninvasive Follicular Thyroid Neoplasms with Papillary-like Nuclear Features (NIFTPs) Identifies a Distinct Proteomic Signature Associated with RAS-Mutant Lesions | Denti, V.; Greco, A.; Alviano, A. M. et al. | International Journal of Molecular Sciences, 25, 23, 13115 | https://doi.org/10.3390/ijms252313115 | 2024 | |
| Differential protease specificity by collagenase as a novel approach to serum proteomics that includes identification of extracellular matrix proteins without enrichment | Macdonald, J. K.; Clift, C. L.; Saunders, J. et al. | Journal of the American Society for Mass Spectrometry, 35, 3, 487-497 | https://doi.org/10.1021/jasms.3c00366 | 2024 | |
| Spatial neurolipidomics—MALDI mass spectrometry imaging of lipids in brain pathologies | Jha, D.; Blennow, K.; Zetterberg, H. et al. | Journal of Mass Spectrometry, 59, 3, e5008 | https://doi.org/10.1002/jms.5008 | 2024 | |
| Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI | Hartig, J. P.; Bejar, K.; Young, L. EA. et al. | Cancer research communications, 4, 11, 3036-3048 | https://doi.org/10.1158/2767-9764.CRC-24-0152 | 2024 | |
| MALDI MSI Protocol for Spatial Bottom-Up Proteomics at Single-Cell Resolution | Grgic, A.; Cuypers, E.; Dubois, L. J. et al. | Journal of Proteome Research, 23, 12, 5372-5379 | https://doi.org/10.1021/acs.jproteome.4c00528 | 2024 | |
| Integration of mass cytometry and mass spectrometry imaging for spatially resolved single-cell metabolic profiling | Nunes, J. B.; Ijsselsteijn, M. E.; Abdelaal, T. et al. | Nature Methods, 21, 10, 1796-1800 | https://doi.org/10.1038/s41592-024-02392-6 | 2024 | |
| Interplatform comparison between three ion mobility techniques for human plasma lipid collision cross sections | George, A. C.; Schmitz, I.; Rouvière, F. et al. | Analytica Chimica Acta, 1304, 342535 | https://doi.org/10.1016/j.aca.2024.342535 | 2024 | |
| Supporting Information Revealing In Situ Molecular Profiles of Glomerular Cell Types and Substructures with Integrated Imaging Mass Spectrometry and Multiplexed Immunofluorescence Microscopy | Esselman, A. B.; Moser, F. A.; Tideman, L. et al. | Kidney International, 107, 2, 332 - 337 | https://doi.org/10.1016/j.kint.2024.11.008 | 2024 | |
| MALDI-MSI-LC-MS/MS Workflow for Single-Section Single Step Combined Proteomics and Quantitative Lipidomics | Hendriks, T. FE; Krestensen, K. K.; Mohren, R. et al. | Analytical Chemistry, 96, 10, 4266-4274 | https://doi.org/10.1021/acs.analchem.3c05850 | 2024 | |
| Detection, quantification, and isomer differentiation of per-and polyfluoroalkyl substances (PFAS) using MALDI-TOF with trapped ion mobility | Reynolds, A. J.; Smith, A. M.; Qiu, T. A. | Journal of the American Society for Mass Spectrometry, 35, 2, 317-325 | https://doi.org/10.1021/jasms.3c00369 | 2024 | |
| Introducing FISCAS, a Tool for the Effective Generation of Single Cell MALDI-MSI Data | Schwenzfeier, J.; Weischer, S.; Bessler, S. et al. | Journal of the American Society for Mass Spectrometry, 35, 12, 2950-2959 | https://doi.org/10.1021/jasms.4c00279 | 2024 | |
| Collision cross sections of large positive fullerene molecular ions and their use as ion mobility calibrants in trapped ion mobility mass spectrometry | Oppenländer, T.; Gross, J. H. | Analytical and Bioanalytical Chemistry, 416, 28, 6187-6197 | https://doi.org/10.1007/s00216-024-05579-0 | 2024 | |
| Single Cell MALDI-MSI Analysis of Lipids and Proteins within a Replicative Senescence Fibroblast Model | Sekera, E. R.; Rosas, L.; Holbrook, J. H. et al. | J. Am. Soc. Mass Spectrom., 35, 12, 2815-2823 | https://doi.org/10.1021/jasms.4c00095 | 2024 | |
| Enhanced surface colonisation and competition during bacterial adaptation to a fungus | Richter, A.; Blei, F.; Hu, G. et al. | Nature Communications, 15, 1, 4486 | https://doi.org/10.1038/s41467-024-48812-1 | 2024 | |
| A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma | Hwang, G. H.; Pazyra-Murphy, M. F.; Seo, H. et al | Cancer Research, 84, 6, 872 | https://doi.org/10.1158/0008-5472.CAN-22-3784 | 2024 | |
| A flavonoid metabolon: cytochrome b 5 enhances B‐ring trihydroxylated flavan‐3‐ols synthesis in tea plants | Ruan, H.; Gao, L.; Fang, Z. et al. | The Plant Journal, 118, 6, 1793 | https://doi.org/10.1111/tpj.16710 | 2024 | |
| Spatial omics reveals molecular changes in focal cortical dysplasia type II | Vermeulen, I.; Rodriguez-Alvarez, N.; François, L. et al. | Neurobiology of Disease, 195, 106491 | https://doi.org/10.1016/j.nbd.2024.106491 | 2024 | |
| Feasibility of MALDI-MSI-Based Proteomics Using Bouin-Fixed Pathology Samples: Untapping the Goldmine of Nephropathology Archives | Bindi, G.; Pagani, L.; Ceku, J. et al. | Journal of Proteome Research, 23, 7, 2542 | https://doi.org/10.1021/acs.jproteome.4c00198 | 2024 | |
| Inflammation‐associated intramyocellular lipid alterations in human pancreatic cancer cachexia | Deng, M.; Cao, J.; van der Kroft, G. et al. | Journal of cachexia, sarcopenia and muscle, 15, 4, 1283 | https://doi.org/10.1002/jcsm.13474 | 2024 | |
| Spatial N-glycomics of the normal breast microenvironment reveal fucosylated and high-mannose N-glycan signatures related to BIRADS density and ancestry | Rujchanarong, D.; Spruill, L.; Sandusky, G. E. et al. | Glycobiology, 34, 8, cwae043 | https://doi.org/10.1093/glycob/cwae043 | 2024 | |
| Molecular, metabolic, and subcellular mapping of the tumor immune microenvironment via 3D targeted and non-targeted multiplex multi-omics analyses | Ferri-Borgogno, S.; Burks, J. K.; Seeley, E. H. et al. | Cancers, 16, 5, 846 | https://doi.org/10.3390/cancers16050846 | 2024 | |
| Serine Supports Epithelial and Immune Cell Function in Colitis | Bai, J. D. K; Saha, S.; Wood, M. C.; Chen, Bo; Li, Jinyu; Dow, Lukas E; Montrose, David C; | The American Journal of Pathology, 194, 6, 927 | https://doi.org/10.1016/j.ajpath.2024.01.021 | 2024 | |
| Extracellular Microenvironment Alterations in Ductal Carcinoma In Situ and Invasive Breast Cancer Pathologies by Multiplexed Spatial Proteomics | Hulahan, T. S.; Spruill, L.; Wallace, E. N. et al. | International Journal of Molecular Sciences, 25, 12, 6748 | https://doi.org/10.3390/ijms25126748 | 2024 | |
| MALDI TIMS IMS Reveals Ganglioside Molecular Diversity within Murine S. aureus Kidney Tissue Abscesses | Djambazova, K. V.; Gibson-Corley, K. N.; Freiberg, J. A. et al. | J. Am. Soc. Mass Spectrom. 35, 8, 1692–1701 | https://doi.org/10.1021/jasms.4c00089 | 2024 | |
| Human Airway Organoids and Multimodal Imaging-Based Toxicity Evaluation of 1-Nitropyrene | Zhou, Y.; Li, C.; Chen, Y. et al. | Environmental Science & Technology, 58, 14, 6083 | https://doi.org/10.1021/acs.est.3c07195 | 2024 | |
| DeepION: A Deep Learning-Based Low-Dimensional Representation Model of Ion Images for Mass Spectrometry Imaging | Guo, L.; Xie, C.; Miao, R. et al. | Analytical Chemistry, 96, 9, 3829 | https://doi.org/10.1021/acs.analchem.3c05002 | 2024 | |
| Spatial metabolomics reveal metabolic alternations in the injured mice kidneys induced by triclocarban treatment | Xie, P.; Chen, J.; Xia, Y. et al. | Journal of Pharmaceutical Analysis, 101024 | https://doi.org/10.1016/j.jpha.2024.101024 | 2024 | |
| Rapid Characterization of Phospholipids from Biological Matrix Enabled by Indium Tin Oxide (ITO) Coated Slide Assisted Enrichment MALDI Mass Spectrometry | Huang, P.; Zhang, H.; Liu, Y. et al. | Analysis & Sensing, 4, 3, e202300097 | https://doi.org/10.1002/anse.202300097 | 2024 | |
| Spatial metabolomics identifies LPC (18: 0) and LPA (18: 1) in advanced atheroma with translation to plasma for cardiovascular risk estimation | Cao, J.; Martin-Lorenzo, M.; van Kuijk, K. et al. | Arteriosclerosis, Thrombosis, and Vascular Biology, 44, 3, 741 | https://doi.org/10.1161/ATVBAHA.123.320278 | 2024 | |
| Optimized combination of MALDI MSI and immunofluorescence for neuroimaging of lipids within cellular microenvironments | Shafer, C. C.; Neumann, E. K. | Frontiers in Chemistry, 12, 1334209 | https://doi.org/10.3389/fchem.2024.1334209 | 2024 | |
| Evaluating Drug Distribution in Rat Lung by Mass Spectrometry Imaging after Dry Powder Insufflation: Comparison of Jet-milling, Spray-drying, and Thin Film Freezing | Moon, C.; Maier, E. Y.; Seeley, E. H. et al. | Journal of Drug Delivery Science and Technology, 106206 | https://doi.org/10.1016/j.jddst.2024.106206 | 2024 | |
| Mass Spectrometry Imaging of Amino Acids Enabled by Quaternized Pyridinium Salt MALDI Probe | Zhou, H.; Yuan, J.; Xu, J. et al. | Analytical Chemistry, 96, 34, 13785 | https://doi.org/10.1021/acs.analchem.4c01147 | 2024 | |
| Integrative Single-Plaque Analysis Reveals Signature Aβ and Lipid Profiles in the Alzheimer’s Brain | Enzlein, T.; Lashley, T.; Sammour, D. A. et al. | Analytical Chemistry, 96, 24, 9799 | https://doi.org/10.1021/acs.analchem.3c05557 | 2024 | |
| Lipid A double bond position determination using ozone and laser-induced dissociation | Mikhael, A.; Petrosova, H.; Smith, D. et al. | Rapid Communications in Mass Spectrometry, 38, 16, e9854 | https://doi.org/10.1002/rcm.9854 | 2024 | |
| Biofortified Rice Provides Rich Sakuranetin in Endosperm | Zhao, Y.; Hu, J.; Zhou, Z. et al. | Rice, 17, 19 | https://doi.org/10.1186/s12284-024-00697-w | 2024 | |
| The mechanism of extracellular CypB promotes glioblastoma adaptation to glutamine deprivation microenvironment | Yin, H.; Liu, Y.; Dong, Q. et al. | Cancer Letters, 597, 216862 | https://doi.org/10.1016/j.canlet.2024.216862 | 2024 | |
| Spatial MS multiomics on clinical prostate cancer tissues | Truong, J. X. M.; Rao, S. R.; Ryan, F. J. et al. | Analytical and Bioanalytical Chemistry, 416, 7, 1745 | https://doi.org/10.1007/s00216-024-05178-z | 2024 | |
| Effects of Sex and Western Diet on Spatial Lipidomic Profiles for the Hippocampus, Cortex, and Corpus Callosum in Mice Using MALDI MSI | Shafer, C. C.; Di Lucente, J.; Mendiola, U. R. et al. | Journal of the American Society for Mass Spectrometry, 35. 11, 2554-2563 | https://doi.org/10.1021/jasms.3c00446 | 2024 | |
| Applying Spatial Metabolomics To Investigate Age-and Drug-Induced Neurochemical Changes | Vallianatou, T.; Angerer, T. B.; Kaya, I. et al. | ACS Chemical Neuroscience, 15, 15, 2822 | https://doi.org/10.1021/acschemneuro.4c00199 | 2024 | |
| Utilization of bis-MPA Dendrimers for the Calibration of Ion Mobility Collision Cross Section Calculations | Sekera, E. R.; Somogyi, Á.; Takáts, Z. et al. | Journal of the American Society for Mass Spectrometry, 35, 6, 1101 | https://doi.org/10.1021/jasms.3c00428 | 2024 | |
| Spatially resolved metabolomic dataset of distinct human kidney anatomic regions | Li, H.; Humphreys, Benjamin D. | Data in Brief, 54, 110431 | https://doi.org/10.1016/j.dib.2024.110431 | 2024 | |
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| Visual authentication of steroidal saponins in Allium macrostemon Bge. and Allium chinense G. Don using MALDI-TOF imaging mass spectrometry and their structure activity relationship | Duan, S.; Li, X.; Yao, Z. et al. | Arabian Journal of Chemistry, 15(10), 104138 | https://doi.org/10.1016/j.arabjc.2022.104138 | 2022 | Biology |
| Unraveling metabolic alterations in transgenic mouse model of Alzheimer's disease using MALDI MS imaging with 4-aminocinnoline-3-carboxamide matrix | Chen, Y.; Hu, D.; Zhao, L.; Tang, W.; Li, B. | Analytica Chimica Acta, 1192, 339337 | https://www.sciencedirect.com/science/article/abs/pii/S0003267021011636 | 2022 | Biology - Clinical |
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| Tattoo Pigment Identification in Inks and Skin Biopsies of Adverse Reactions by Complementary Elemental and Molecular Bioimaging with Mass Spectral Library Matching | Brungs, C.; Schmid, R.; Wolf, C. et al. | Analytical Chemistry, 94(8), 3581-3589 | https://doi.org/10.1021/acs.analchem.1c04922 | 2022 | Chemistry – Basic Research |
| Spatially resolved characterization of tissue metabolic compartments in fasted and high-fat diet livers | Stopka, S. A.; van der Reest, J.; Abdelmoula, W. M. et al. | PLOS ONE, 17(9), e0261803 | https://doi.org/10.1371/journal.pone.0261803 | 2022 | Biology - Clinical |
| Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma | Coy, S.; Wang, S.; Stopka, S. A. et al. | Nature Communications, 13(1), 4814 | https://doi.org/10.1038/s41467-022-32430-w | 2022 | Biology - Clinical |
| Shielding the oil reserves: the scutellum as a source of chemical defenses | Murphy, K. M.; Poretsky, E.; Liu, H. et al. | Plant Physiology, 188(4), 1944-1949 | https://doi.org/10.1093/plphys/kiac038 | 2022 | Biology |
| Novel Combined Enzymatic Approach to Analyze Nonsialylated N-Linked Glycans through MALDI Imaging Mass Spectrometry | Andrew, T. D.; Hongyan, L.; Richard, R. D. et al. | J Proteome Res. 21(8), 1930-1938 | https://doi.org/10.1021/acs.jproteome.2c00193 | 2022 | Biology - Clinical |
| Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells, biomarkers, and response to substrate reduction therapy | Boddupalli, C. S.; Nair, S.; Belinsky, G. et al. | eLife, 11, e79830 | https://doi.org/10.7554/elife.79830 | 2022 | Biology - Clinical |
| Neglected Very Long-Chain Hydrocarbons and the Incorporation of Body Surface Area Metrics Reveal Novel Perspectives for Cuticular Profile Analysis in Insects | Golian, M.; Bien, T.; Schmelzle, S. et al. | Insects, 13, 1, 83 | https://doi.org/10.3390/insects13010083 | 2022 | Biology |
| Mass spectrometry imaging to explore molecular heterogeneity in cell culture | Bien, T.; Koerfer, K.; Schwenzfeier, J. et al. | Proceedings of the National Academy of Sciences of the United States of America, 119(29), e2114365119 | https://doi.org/10.1073/pnas.2114365119 | 2022 | Biology |
| MALDI Mass Spectrometry Imaging for the Distinction of Adenocarcinomas of the Pancreas and Biliary Tree | Bollwein, C.; Gonҫalves, J. P. L.; Utpatel, K. et al. | Molecules, 27(11), 3464 | https://doi.org/10.3390/molecules27113464 | 2022 | Biology - Clinical |
| LPS-induced lipid alterations in microglia revealed by MALDI mass spectrometry-based cell fingerprinting in neuroinflammation studies | Blank, M.; Enzlein, T.; Hopf, C. et al. | Scientific Reports, 12(1), 2908 | https://doi.org/10.1038/s41598-022-06894-1 | 2022 | Biology - Clinical |
| Lactate is an epigenetic metabolite that drives survival in model systems of glioblastoma | Torrini, C.; Nguyen, T. T. T.; Shu, C. et al. | Molecular Cell, 82(16), 3061-3076.e6 | https://doi.org/10.1016/j.molcel.2022.06.030 | 2022 | Biology - Clinical |
| Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context | Goossens, P.; Lu, C.; Cao, J. et al. | Cell Metabolism, 34(8), 1214-1225.e6 | https://doi.org/10.1016/j.cmet.2022.06.012 | 2022 | Biology - Clinical |
| In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues | Young, L. E. A.; Conroy, L. R.; Clarke, H. A. et al. | EMBO Molecular Medicine, e16029 | https://doi.org/10.15252/emmm.202216029 | 2022 | Biology |
| Imaging Mass Spectrometry Reveals Complex Lipid Distributions Across Staphylococcus aureus Biofilm Layers | Rivera, E. S.; Weiss, A.; Migas, L. G. et al. | Journal of Mass Spectrometry and Advances in the Clinical Lab, 26, 36-46 | https://doi.org/10.1016/j.jmsacl.2022.09.003 | 2022 | Biology |
| Imaging Mass Spectrometry Reveals Alterations in N-Linked Glycosylation That Are Associated With Histopathological Changes in Nonalcoholic Steatohepatitis in Mouse and Human | Ochoa-Rios, S.; O'Connor, I. P.; Kent, L. N. et al. | Molecular & Cellular Proteomics, 21(5), 100225 | https://doi.org/10.1016/j.mcpro.2022.100225 | 2022 | Biology - Clinical |
| Home-Built Spinning Apparatus for Drying Agarose-Based Imaging Mass Spectrometry Samples | Lusk, H. J.; Levy, S. E.; Bergsten, T. M. et al. | Journal of The American Society for Mass Spectrometry, 33(7), 1325-1328 | https://doi.org/10.1021/jasms.2c00044 | 2022 | Protocol |
| Forensic Discrimination of Differentially Sourced Animal Blood Using a Bottom-Up Proteomics Based MALDI MS Approach | Kennedy, K.; Cole, L.; Witt, M. et al. | Molecules, 27(7), 2039 | https://doi.org/10.3390/molecules27072039 | 2022 | Forensic |
| Establishment of a transparent soil system to study Bacillus subtilis chemical ecology | Lozano-Andrade, C. N.; Nogueira, C. G.; Wibowo, M. et al. | ISME Communications, 3,110 | https://doi.org/10.1101/2022.01.10.475645 | 2022 | Biology |
| Development of an Automatic Ultrasonic Matrix Sprayer for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging | Meng, L.; Han, J.; Chen, J. et al. | Analytical Chemistry, 94(17), 6457-6462 | https://doi.org/10.1021/acs.analchem.2c00403 | 2022 | Method Development |
| Development of a cell‐free strategy to recover aged skeletal muscle after disuse | Wu, Y.; De La Toba, E. A.; Dvoretskiy, S. et al. | The Journal of Physiology, 600(13), 3029-3030 | https://doi.org/10.1113/JP282867 | 2022 | Biology - Clinical |
| De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma | Shi, D. D.; Savani, M. R.; Levitt, M. M. et al. | Cancer Cell, 40(9), 939-956.e16 | https://doi.org/10.1016/j.ccell.2022.07.011 | 2022 | Biology - Clinical |
| Co-culture with Acinetobacter johnsonii enhances benzalkonium chloride resistance in Salmonella enterica via triggering lipid A modifications | Wilson, A.; Fegan, N.; Turner, M. S. et al. | International Journal of Food Microbiology, 381, 109905 | https://doi.org/10.1016/j.ijfoodmicro.2022.109905 | 2022 | Biology |
| A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine | Sebastian, C.; Ferrer, C.; Serra, M. et al. | Nature Communications, 13(1), 1503 | https://doi.org/10.1038/s41467-022-29085-y | 2022 | Biology - Clinical |
| A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma | Pal, S.; Kaplan, J. P.; Nguyen, H. et al. | Cancer Cell, 40(9), 957-972.e10 | https://doi.org/10.1016/j.ccell.2022.07.012 | 2022 | Biology - Clinical |
| ‘On the Spot’ Digital Pathology of Breast Cancer Based on Single-Cell Mass Spectrometry Imaging | Cuypers, E.; Claes, B. S. R.; Biemans, R. et al. | Analytical Chemistry, 94(16), 6180-6190 | https://doi.org/10.1021/acs.analchem.1c05238 | 2022 | Biology - Clinical |
| High Spatial Resolution MALDI Imaging Mass Spectrometry of Fresh-Frozen Bone | Good, C. J.; Neumann, E. K.; Butrico, C. E. et al. | Analytical Chemistry, 94(7), 3165-3172 | https://doi.org/10.1021/acs.analchem.1c04604 | 2022 | Biology |
| Removal of optimal cutting temperature (O.C.T.) compound from embedded tissue for MALDI imaging of lipids | Truong, J. X. M.; Spotbeen, X.; White, J. et al. | Analytical and Bioanalytical Chemistry, 413, 2695-2708 | https://doi.org/10.1007/s00216-020-03128-z | 2021 | Method Development |
| Rapid visualization of lipopeptides and potential bioactive groups of compounds by combining ion mobility and MALDI imaging mass spectrometry | McCann, A.; Kune, C.; La Rocca, R. et al. | Drug Discovery Today: Technologies, 39, 81-88 | https://doi.org/10.1016/j.ddtec.2021.08.003 | 2021 | Chemistry – Basic Research |
| Protocol for multimodal analysis of human kidney tissue by imaging mass spectrometry and CODEX multiplexed immunofluorescence | Neumann, E. K.; Patterson, N. H.; Allen, J. L. et al. | STAR Protocols, 2(3), 100747 | https://doi.org/10.1016/j.xpro.2021.100747 | 2021 | Protocol |
| Mass Spectrometry Imaging of Low-Molecular-Weight Phenols Liberated from Plastics | Xu, Q.; Tian, R.; Lu, C. et al. | Analytical Chemistry, 93(40), 13703-13710 | https://pubs.acs.org/doi/10.1021/acs.analchem.1c03397 | 2021 | Chemistry – Basic Research |
| Evaluation of Therapeutic Collagen-Based Biomaterials in the Infarcted Mouse Heart by Extracellular Matrix Targeted MALDI Imaging Mass Spectrometry | Clift, C. L.; McLaughlin, S.; Muñoz, M. et al. | Journal of The American Society for Mass Spectrometry 32 (12), 2746-2754 | https://pubs.acs.org/doi/10.1021/jasms.1c00189 | 2021 | Biology - Clinical |
| Detection and mapping of haemoglobin variants in blood fingermarks by MALDI MS for suspect “profiling”. | Heaton, C.; Witt, M.; Cole, L. et al. | Analyst, 146, 4290 | https://doi.org/10.1039/d1an00578b | 2021 | Chemistry – Basic Research |
| Complementing Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry Imaging with Chromatography Data for Improved Assignment of Isobaric and Isomeric Phospholipids Utilizing Trapped Ion Mobility-Mass Spectrometry | Helmer, P. O.; Nordhorn, I. D.; Korf, A. et al. | Analytical Chemistry, 93, 2135-2143 | https://doi.org/10.1021/acs.analchem.0c03942 | 2021 | Chemistry – Basic Research |
| Automated Biomarker Candidate Discovery in Imaging Mass Spectrometry Data Through Spatially Localized Shapley Additive Explanations | Tideman, L. E. M.; Migas, L. G.; Djambazova, K. V. et al. | Analytica Chimica Acta, 1177, 338522 | https://doi.org/10.1016/j.aca.2021.338522 | 2021 | Chemistry – Basic Research |
| Absolute quantification of 2-hydroxyglutarate on tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging for rapid and precise identification of isocitrate dehydrogenase mutations in human glioma | Chunyan, L.; Hainan, L.; Lei, W. et al. Rumeng Zhang, Xiaoai Yuan, Taihua Wu, Jie Wu, Ming Lu, Xu Ma | Int. J. Cancer., 149, 12, 2091-2098 | https://doi.org/10.1002/ijc.33729 | 2021 | Biology - Clinical |
| Traumatic brain injury induces region-specific glutamate metabolism changes as measured by multiple mass spectrometry methods | Sowers, J. L.; Sowers, M. L.; Shavkunov, A. S. et al. | iScience 24(10), 103108 | https://doi.org/10.1016/j.isci.2021.103108 | 2021 | Biology - Clinical |
| Preserved and variable spatial-chemical changes of lipids across tomato leaves in response to central vein wounding reveals potential origin of linolenic acid in signal transduction cascade. | Veličković, D.; Chu, R. K.; Henkel. C. et al. | Journal of Plant-Environment Interactions 2(1), 28-35 | https://doi.org/10.1002/pei3.10038 | 2021 | Biology |
| Multiplexed imaging mass spectrometry of the extracellular matrix using serial enzyme digests from formalin-fixed paraffin-embedded tissue sections | Clift, C. L.; Drake, R. R.; Mehta, A. et al. | Analytical and Bioanalytical Chemistry, 413, 2709-2719 | https://doi.org/10.1007/s00216-020-03047-z | 2021 | Biology |
| Imaging Mass Spectrometry and Lectin Analysis of N-linked Glycans in Carbohydrate Antigen Defined Pancreatic Cancer Tissues | McDowell, C. T.; Klamer, Z.; Hall, J. et al. | Molecular & Cellular Proteomics 20, 100012 | https://doi.org/10.1074/mcp.RA120.002256 | 2021 | Biology - Clinical |
| Direct N-Glycosylation Profiling of Urine and Prostatic Fluid Glycoproteins and Extracellular Vesicles | Blaschke, C. R. K.; Hartig, J. P.; Grimsley, G. et al. | Frontiers in Chemistry 9, 734280 | https://www.frontiersin.org/articles/10.3389/fchem.2021.734280/full | 2021 | Biology |
| CRL4AMBRA1 is a master regulator of D-type cyclins. | Simoneschi, D.; Rona, G.; Zhou, N. et al. | Nature, 592, 789-793 | https://doi.org/10.1038/s41586-021-03445-y | 2021 | Biology - Clinical |
| Complete spatial characterisation of N-glycosylation upon striatal neuroinflammation in the rodent brain. | Rebelo, A. L.; Gubinelli, F.; Roost, P. et al. | Journal of Neuroinflammation, 18, 116 | https://doi.org/10.1186/s12974-021-02163-6 | 2021 | Biology |
| Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH | Dudek, M.; Pfister, D.; Donakonda, S. et al. | Nature, 592, 444-449 | https://doi.org/10.1038/s41586-021-03233-8 | 2021 | Biology - Clinical |
| β‑Cyclodextrin-poly (β-Amino Ester) Nanoparticles Are a Generalizable Strategy for High Loading and Sustained Release of HDAC Inhibitors | Chaudhuri, S.; Fowler, M. J.; Baker, C. et al. | Applied Materials & Interface, 13, 20960-20973 | https://doi.org/10.1021/acsami.0c22587 | 2021 | Biology - Clinical |
| Rapid N-Glycan Profiling of Serum and Plasma by a Novel Slide-Based Imaging Mass Spectrometry Workflow | Blaschke, C. R. K.; Black, A. P.; Mehta, A. S. et al. | Journal of the American Society for Mass Spectrometry, 31, 2511-2520 | https://doi.org/10.1021/jasms.0c00213 | 2020 | Chemistry – Basic Research |
| MS Imaging‐Guided Microproteomics for Spatial Omics on a Single Instrument | Dewez, F.; Oetjen, J.; Henkel, C. et al. | Proteomics, 20, 23, 1900369 | https://doi.org/10.1002/pmic.201900369 | 2020 | Chemistry – Basic Research |
| Spatial Metabolomics of the Human Kidney using MALDI Trapped Ion Mobility Imaging Mass Spectrometry. | Neumann, E. K.;Migas, L. G.; Allen, J. L. et al. | Analytical Chemistry 92(19), 13084-13091 | https://doi.org/10.1021/acs.analchem.0c02051 | 2020 | Biology |
| Resolving the Complexity of Spatial Lipidomics Using MALDI TIMS Imaging Mass Spectrometry | Djambazova, K. V.; Klein, D. R.; Migas, L. G. et al. | Analytical Chemistry, 92(19), 13290-13297 | https://doi.org/10.1021/acs.analchem.0c02520 | 2020 | Biology |
| Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging | Ščupáková,, K.; Dewez, F.; Walch, A. K. et al. | Angewandte Chemie International Edition 59(40), 17447-17450 | https://doi.org/10.1002/anie.202007315 | 2020 | Biology - Clinical |
| Modulating Isoprenoid Biosynthesis Increases Lipooligosaccharides and Restores Acinetobacter baumannii Resistance to Host and Antibiotic Stress | Palmer, L. D.; Minor, K. E.; Mettlach, J. A. et al. | Cell Reports, 32(10), 108129 | https://doi.org/10.1016/j.celrep.2020.108129 | 2020 | Biology - Clinical |
| Mass‐Spectrometric Imaging of Electrode Surfaces—a View on Electrochemical Side Reactions | Fangmeyer, J.; Behrens, A.; Gleede, B. et al. | Angewandte Chemie, 132(46), 20608-20613 | https://doi.org/10.1002/ange.202010134 | 2020 | Chemistry – Basic Research |
| Lipidomic profiling of clinical prostate cancer reveals targetable alterations in membrane lipid composition | Butler, L. M.; Mah, C. Y.; Machiels, J. et al. | Cancer Research,81, 19, 4981-4993 | https://doi.org/10.1158/0008-5472.CAN-20-3863 | 2020 | Biology - Clinical |
| In situ isobaric lipid mapping by MALDI–ion mobility separation–mass spectrometry imaging | Fu, T.; Oetjen, J.; Chapelle, M. et al. | Journal of Mass Spectrometry 55(9), e4531 | https://doi.org/10.1002/jms.4531 | 2020 | Biology |
| Hydroperoxylated vs Dihydroxylated Lipids: Differentiation of Isomeric Cardiolipin Oxidation Products by Multidimensional Separation Techniques | Helmer, P.O.; Behrens, A.; Rudt, E. et al. | Analytical Chemistry 92(17), 12010-12016 | https://doi.org/10.1021/acs.analchem.0c02605 | 2020 | Biology |
| High-Performance Molecular Imaging with MALDI Trapped Ion-Mobility Time-of-Flight (timsTOF) Mass Spectrometry | Spraggins, J. M.; Djambazova, K. V.; Rivera, E. S. et al. | Analytical Chemistry 91(22), 14552-14560 | https://doi.org/10.1021/acs.analchem.9b03612 | 2019 | Chemistry – Basic Research |
| Detection of small molecule concentration gradients in ocular tissues and humours | Boughton, B.A.; Thomas, O. R. B.; Demarais, N. J. et al. | Journal of Mass Spectrometry 55(4), e4460 | https://doi.org/10.1002/jms.4460 | 2019 | Biology |
timsTOF fleX MALDI-2
| TITLE | AUTHOR | PUBLICATION | LINK | YEAR | APPLICATION |
|---|---|---|---|---|---|
| msiFlow: automated workflows for reproducible and scalable multimodal mass spectrometry imaging and microscopy data analysis | Spangenberg, P.; Bessler, S.; Widera, L. et al. | Nature Communications, 16, 1, 1065 | https://doi.org/10.1038/s41467-024-55306-7 | 2025 | |
| Microscopy and spatial-metabolomics identify tissue-specific metabolic pathways uncovering salinity and drought tolerance mechanisms in Avicennia marina and Phoenix dactylifera roots | Oyarce, P.; Xiao, T. T.; Henkel, C. et al. | Scientific Reports, 15, 1, 1076 | https://doi.org/10.1038/s41598-025-85416-1 | 2025 | |
| MALDI-2 Mass Spectrometry Imaging enables spatial visualization of endocannabinoids in brain | Salviati, E.; Guida, F.; La Gioia, D. et al. | Talanta, 127811, in press | https://doi.org/10.1016/j.talanta.2025.127811 | 2024 | |
| MALDI and MALDI-2 mass spectrometry imaging contribute to revealing the alternations in lipid metabolism in germinating soybean seeds | Xie, P.; Chen, J.; Xia, Y. et al. | Chinese Chemical Letters, 110595, in press | https://doi.org/10.1016/j.cclet.2024.110595 | 2024 | |
| Optimized MALDI2-Mass Spectrometry Imaging for Stable Isotope Tracing of Tissue-Specific Metabolic Pathways in Mice | Chen, Y.; Song, Y.; Yang, Z. et al. | Analytical Chemistry, 97, 1, 499-507 | https://doi.org/10.1021/acs.analchem.4c04600 | 2024 | |
| Experimental and Computational Evaluation of Lipidomic In-Source Fragmentation as a Result of Postionization with Matrix-Assisted Laser Desorption/Ionization | Vandergrift, G. W.; Kew, W.; Andersen, A. et al. | Anal Chem. 2024, 96, 41, 16127-16133 | https://doi.org/10.1021/acs.analchem.4c00258 | 2024 | |
| Cell type specific regulation of phenolic acid and flavonoid metabolism in Taxus mairei leaves | Zhan, X.; Liang, X.; Lin, W. et al. | Industrial Crops and Products, 219, 118975 | https://doi.org/10.1016/j.indcrop.2024.118975 | 2024 | |
| Mapping Spatiotemporal Heterogeneity in Multifocal Breast Tumor Progression by Noninvasive Ultrasound Elastography-Guided Mass Spectrometry Imaging Strategy | Zhou, P.; Xiao, Y.; Zhou, X. et al. | JACS Au, 4, 2, 465 | https://doi.org/10.1021/jacsau.3c00589 | 2024 | |
| Recent strategies for improving MALDI mass spectrometry imaging performance towards low molecular weight compounds | Sun, Z.; Wang, F.; Liu, Y. et al. | TrAC Trends in Analytical Chemistry, 117727 | https://doi.org/10.1016/j.trac.2024.117727 | 2024 | |
| Mass Spectrometry Imaging and Histology for the Analysis of Budding Intestinal Organoids | Sekera, E. R.; Akkaya-Colak, K. B.; Lopez, A. et al. | Analytical Chemistry, 96, 10, 4251 | https://doi.org/10.1021/acs.analchem.3c05725 | 2024 | |
| Large-Scale Screening of Pharmaceutical Compounds to Explore the Application Space of On-Tissue MALDI and MALDI-2 Mass Spectrometry | Soltwisch, J.; Palmer, A.; Hong, H. et al. | Analytical Chemistry, 96, 25, 10294 | https://doi.org/10.1021/acs.analchem.4c01088 | 2024 | |
| MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids | Chen, J.; Xie, P.; Wu, P. et al. | Chinese Chemical Letters, 35, 4, 108895 | https://doi.org/10.1016/j.cclet.2023.108895 | 2024 | |
| De novo phytosterol synthesis in animals | Michellod, D.; Bien, T.; Birgel, D. et al. | Science, 380, 6644, 520-526 | https://doi.org/10.1126/science.add7830 | 2023 | |
| Spatial lipidomics and metabolomics of multicellular tumor spheroids using MALDI-2 and trapped ion mobility imaging | Chen, J.; Xie, P.; Dai, Q. et al. | Talanta, 265, 124795 | https://doi.org/10.1016/j.talanta.2023.124795 | 2023 | |
| Spatial Metabolomics and Lipidomics Reveal the Mechanisms of the Enhanced Growth of Breast Cancer Cell Spheroids Exposed to Triclosan | Chen, Jing; Xie, Peisi; Wu, Pengfei; Lin, Zian; He, Yu; Cai, Zongwei | Environmental Science and Technology 6, 1, 509 | https://doi.org/10.1021/acs.est.3c01746 | 2023 | Biology - Clinical |
| Mass spectrometry imaging and single-cell transcriptional profiling reveal the tissue-specific regulation of bioactive ingredient biosynthesis in Taxus leaves | Zhan, Xiaori; Qiu, Tian; Zhang, Hongshan; Hou, Kailin; Liang, Xueshuang; Chen, Cheng; Wang, Zhijing; Wu, Qicong; Wang, Xiaojia; Li, Xiao-Lin; Wang, Mingshuang; Feng, Shangguo; Zeng, Houqing; Yu, Chunna; Wang, Huizhong; Shen, Chenjia | Plant Communications 9, 1, eade8898 | https://doi.org/10.1016/j.xplc.2023.100630 | 2023 | Biology |
| Negative Ion-Mode N-Glycan Mass Spectrometry Imaging by MALDI-2-TOF-MS | Soltwisch, Jens; Heijs, Bram | Methods in Molecular Biology, 173-186 | https://doi.org/10.1007/978-1-0716-3319-9_15 | 2023 | Protocol |
| Cryo-ultramicrotomy and Mass Spectrometry Imaging Analysis of Nudibranch Microstructures | Hamilton, B.R.; Chan, W.; Cheney, K. L.; Sullivan, R.K.P.; Floetenmeyer, M.; Garson, M. J.; Wepf, R. | J. Am. Soc. Mass Spectrom., 33, 3, 592–597 | https://doi.org/10.1021/jasms.1c00254 | 2022 | Biology |
| Three-Dimensional Mass Spectrometry Imaging Reveals Distributions of Lipids and the Drug Metabolite Associated with the Enhanced Growth of Colon Cancer Cell Spheroids Treated with Triclosan | Xie, P., Zhang, H., Wu, P. et. al. | Analytical Chemistry, 94(40), 13667-13675 | https://doi.org/10.1021/acs.analchem.2c00768 | 2022 | Biology - Clinical |
| Spatial Distribution of Isobaric Androgens in Target Tissues Using Chemical Derivatization and MALDI-2 on a Trapped Ion Mobility Quadrupole Time-of-Flight Instrument | Mackay, C. L.; Soltwisch, J.; Heijs, B.; Smith, K. W.; Cruickshank, F. L.; Nyhuis, A.; Dreisewerd, K.; Cobice, D. | RSC Advances, 11,33916-33925 | https://doi.org/10.1039/d1ra06086d | 2021 | Biology - Clinical |
| Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI | Andersen, M. K.; Høiem, T. S.; Claes, B. S. R. et al. | Cancer & Metabolism 9, Article number: 9 | https://doi.org/10.1186/s40170-021-00242-z | 2021 | Biology - Clinical |
| Molecular insights into symbiosis — mapping sterols in a marine flatworm-algae-system using high spatial resolution MALDI-2-MS imaging with ion mobility separation | Bien, T; Hambleton, E. A; Dreisewerd, K. et al. | Analytical and Bioanalytical Chemistry 413, 2767-2777 | https://doi.org/10.1007/s00216-020-03070-0 | 2021 | Biology |
| MALDI-2 on a Trapped Ion Mobility Quadrupole Time-of-Flight Instrument for Rapid Mass Spectrometry Imaging and Ion Mobility Separation of Complex Lipid Profiles | Soltwisch, J.; Heijs, B.; Koch, A. et. al | Analytical Chemistry, 92, 8697-8703 | https://doi.org/10.1021/acs.analchem.0c01747 | 2020 | Chemistry – Basic Research |
| MALDI‑2 for the Enhanced Analysis of N‑Linked Glycans by Mass Spectrometry Imaging | Heijs, B.; Potthoff, A.; Soltwisch, J. et al. | Analytical Chemistry, 92, 13904-13911 | https://doi.org/10.1021/acs.analchem.0c02732 | 2020 | Chemistry – Basic Research |
For Research Use Only. Not for use in clinical diagnostic procedures.