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Improving the Annotation for Spatial Proteomics: A Computational Approach to Enhance Molecular Characterization of Thyroid Nodules
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Coelho, Vasco; Monza, Nicole; Porto, Natalia S; Capitoli, Giulia; L’Imperio, Vincenzo; Papetti, Daniele M; Denti, Vanna;
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Journal of Proteome Research, 25, 2, 1152-1159
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https://doi.org/10.1021/acs.jproteome.5c00432
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2026
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Spatial metabolome of Polygala tenuifolia and Polygala sibirica roots by matrix-assisted laser desorption/ionization mass spectrometry imaging
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Zhu, Yihan; Shen, Jie; Zhang, Yilei; Zhang, Gang; Gao, Jing; Yang, Xinjie; Zhang, Fusheng; Yan, Yonggang; Yang, Bingyue; Peng, Liang;
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Industrial Crops and Products, 240, 122642
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https://doi.org/10.1016/j.indcrop.2026.122642
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2026
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The Microbiome Modulates Corneal Wound Healing via the Induction of Cholesterol Sulfotransferase Pathway
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Ogawa, Mamoru; Isobe, Yosuke; Uchino, Haruki; Hirayama, Masatoshi; Kato, Tamotsu; Negishi, Kazuno; Arita, Makoto;
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The FASEB Journal, 40, 2, e71429
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https://doi.org/10.1096/fj.202503669R
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2026
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Dissecting the role of comS-independent srf expression on multicellular differentiation and competence development in Bacillus subtilis
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Miercke, Sarah; Knepper, Jan-Philipp; Dreisewerd, Klaus; Mascher, Thorsten;
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Frontiers in Microbiology, 17, 1753310
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https://doi.org/10.3389/fmicb.2026.1753310
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2026
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Periodic fasting and refeeding re-shapes lipid saturation, storage, and distribution in brown adipose tissue
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Zhang, Xing; Jiang, Ting; Wang, Chunqing; Montenegro Vazquez, Valeria F; Wu, Dandan; Yang, Xin; Le, Que; Sun, Melody S; Wang, Xiaofei; Yang, Xuexian O;
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PLoS Biology, 24, 1, e3003593
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https://doi.org/10.1371/journal.pbio.3003593
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2026
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Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma
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Bernardi, Flavia; Torrejon, Jacob; Basili, Irene; Van Ommeren, Randy; Marsaud, Véronique; Yu, Hua; Talbot, Julie; Souphron, Judith; Indersie, Emilie; Forget, Antoine;
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Cancer Cell, 44, 2, 383-404
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https://doi.org/10.1016/j.ccell.2025.12.012
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2026
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Dynamic Spatial Metabolomics Reveals Region-Specific Metabolic Reprogramming and Markers during Vascular Cognitive Impairment Progression
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Liu, Lin; Yang, Yang; Qu, Zhongyuan; Wu, Shuang; Zou, Xiang; Wang, Dongxue;
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ACS Chemical Neuroscience, 17, 3, 525-536
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https://doi.org/10.1021/acschemneuro.5c00528
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2026
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Novel Insights into the Distribution and Effects of Perfluorooctanesulfonic acid (PFOS) in the Nervous System of a Frog Tadpole Model by Mass Spectrometry Imaging
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Poulsen, Rikke; Field, Emma M; Jackson, Angela M; Kuecks-Winger, Haley; Thambirajah, Anita A; Goodlett, David R; Helbing, Caren C; Pětrošová, Helena;
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Environmental Science & Technology, 60, 4, 3121-3134
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https://doi.org/10.1021/acs.est.5c17483
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2026
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Evaluating Batch Correction Methods for Large-Scale Mass Spectrometry Imaging of Heterogeneous Tissues
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Metodiev, Martin; Dexter, Alex; Zhou, Weiwei; González-Fernández, Ariadna; Nikula, Chelsea; Johns, Lucy M; Karali, Evdoxia; Kazanc, Emine; Tsalikis, Athanasios; Tripp, Aurelien;
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Analytical Chemistry, 98, 5, 3531-3543
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https://doi.org/10.1021/acs.analchem.5c04371
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2026
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Cohort‐Scale Spatial Autocorrelation for Tumor Prediction in Mid‐Infrared Pathology and Spatial Biomarker Discovery Using MALDI Imaging Lipidomics
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Rittel, Miriam F; Ebert, Nikolas; Abu Sammour, Denis; Graf, Sebastian; Fröhlich, Björn C; Birgin, Emrullah; Mohammed, Shad A; Rahbari, Nuh N; Wellmann, Axel; Wasenmüller, Oliver;
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Advanced Science, e16847
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https://doi.org/10.1002/advs.202516847
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2026
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Spatiotemporal metabolic mapping reveals diet-independent remodeling of the postnatal mouse brain
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York, Elisa M; Miller, Anne; Stopka, Sylwia A; Agar, Nathalie YR; Yellen, Gary;
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npj Metabolic Health and Disease, 4, 1, 7
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https://doi.org/10.1038/s44324-025-00098-7
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2026
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Human neuromuscular organoids mimic cancer-induced muscle cachexia
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Chiolerio, Pietro; Auletta, Beatrice; Pezzini, Camilla; Sartore, Luigi; Gregolon, Giorgia; Gagliano, Onelia; Laterza, Cecilia; Valdez, Valeria Roxana Balmaceda; Cacchiarelli, Davide; Luni, Camilla;
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Cell Reports Methods, 6, 2
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https://doi.org/10.1016/j.crmeth.2026.101331
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2026
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Lipidomic Profiling of Rabbit VX2 Tumors Using Matrix-assisted Laser Desorption Ionization Mass Spectrometry Imaging
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Khavandi, Mohammad Mahdi; Crouch, A Colleen; Stolley, Danielle L; Seeley, Erin H; Cressman, Erik NK;
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Radiology: Imaging Cancer, 8, 2, e250588
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https://doi.org/10.1148/rycan.250588
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2026
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DMEM and EMEM as alternate growth media for pathogenic Leptospira
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Garcia, Leandro E; Lin, Zitong; Culos, Sophie; Muenker, M Catherine; Johnson, Emily E; Wang, Zheng; Lopez-Giraldez, Francesc; Giraud-Gatineau, Alexandre; Jackson, Angela M; Picardeau, Mathieu;
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PLOS Neglected Tropical Diseases, 20, 3, e0014136
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2026
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Spatial Multiomics Combining Lipids and Gene Expression Using MALDI ISH MSI
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Vanderschoot, Kyle A; Padilla, Jacob P; Steineman, Kelli A; De Caro, Christopher M; Wang, Yongheng; Wang, Aijun; Heffern, Marie C; Neumann, Elizabeth K;
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Analytical Chemistry, 98, 12, 8839-8850
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https://doi.org/10.1021/acs.analchem.5c02567
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2026
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Optimization of Ionic Matrix Deposition to Increase the Performance of MALDI‐Based Spatial N‐Glycomics
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Vandyk, Heidi; Anderton, Christopher; Lee, Hak Joo; Sharma, Kumar; Veličković, Dušan;
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Journal of Mass Spectrometry, 61, 4, e70053
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https://doi.org/10.1002/jms.70053
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2026
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BPM31510 Increases the CoQ Pool in Chemically Induced CoQ‐Deficient Cells, CoQ‐Deficient Patient Fibroblasts, and in Metabolically Active Murine Tissues
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Aristizabal‐Henao, Juan J; Wessel, Sarah R; Stopka, Sylwia A; Karmacharya, Srada; Van Cura, Devon; Pesini, Alba; Nickerson, Kelsey R; Grover, Kashni; Zavidij, Oksana; Ravi, Archna;
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The FASEB Journal, 40, 7, e71737
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https://doi.org/10.1096/fj.202503629RR
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2026
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Multiplexed spatial screening of extrahepatic lipid-based nanoparticles for in vivo messenger RNA targeting
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Enzlein, Thomas; Schumacher, Jens; Geisel, Alexander; Keller, Florian; Houben, Astrid; Walzer, Kerstin C; Rittel, Miriam F; Fröhlich, Björn C; Cairns, James L; Cordes, Jonas;
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Journal of Controlled Release, 392, 114728
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https://doi.org/10.1016/j.jconrel.2026.114728
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2026
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A high-throughput biocatalytic platform for screening isomeric kainoid natural products
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Shepherd, Robert A; Ramachandra, Manasa; Hopiavuori, Austin R; Jones, Melanie C; Fihn, Conrad A; Tabag, Alex J; Manjunath, Ananya; Gad, Limar Y; Whipple, Chloe R; McKinnie, Shaun MK;
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Cell Reports Physical Science, 7, 2
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https://doi.org/10.1016/j.xcrp.2025.103092
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2026
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MALDI-FISH for Colocalization of Brominated Metabolites and Pseudovibrio spp. in Aplysina Tissue
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McAtamney, Allyson; Lagousis, Cayla; Colquitt, Bradley M; Pita, Lucia; Eustaquio, Alessandra S; Sanchez, Laura M;
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Journal of natural products, 89, 2, 795-803
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https://doi.org/10.1021/acs.jnatprod.5c01555
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2026
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Non-Decalcified Human Teeth Sample Preparation Method for MALDI Mass Spectrometry Imaging
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Bender, Kayle J; Spurgeon, Joanna E; Zhai, Chuo Ying; Arora, Manish; Neumann, Elizabeth K;
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Analytica Chimica Acta, 1402, 345386
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https://doi.org/10.1016/j.aca.2026.345386
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2026
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SMASH Imaging: A Serial Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Strategy for High-Resolution Imaging Facilitates Dual-Polarity and MS2 Spatial Lipidomics on a Single Tissue Section
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Uchino, Haruki; Tsugawa, Hiroshi; Arita, Makoto;
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Analytical Chemistry, 98, 13, 9540-9554
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https://doi.org/10.1021/acs.analchem.5c03738
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2026
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Single-Section Sequential MALDI-MSI Reveals Metabolic and N-Glycan Remodeling During Malignant Transformation in Hepatocellular Adenoma
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Xu, Jianfeng; Sui, Jian; Xu, Da; Zhou, Xiaoxue; Hu, Youhong; Yuan, Jie; Liu, Jia; Lu, Lu;
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Metabolites, 16, 4, 217
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2026
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From Sample to Mixed Reality: A Translational 3D MALDI Imaging Platform for Advanced 3D Spatial Omics Analysis of 3D Cell Culture Disease Models
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Iakab, Stefania Alexandra; Cordes, Jonas; Enzlein, Thomas; Keller, Florian; Kastner, Kevin; Mulholland, Theresa; Fröhlich, Björn Christian; Gruber, Lars; Cairns, James Lucas; Schmidt, Stefan;
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Advanced science, 13, 12, e16098
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https://doi.org/10.1002/advs.202516098
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2026
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MALDI-TOF mass spectrometry imaging of sulfatide lipid expression in the CNS of mice with experimental autoimmune encephalomyelitis
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Berlin, Krista A; Huizar, Carol Chase; Garza, Celeste; Forsthuber, Thomas G; Bach, Stephan BH;
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Scientific Reports, 16, 11462
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https://doi.org/10.1038/s41598-026-41147-5
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2026
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In situ, antibody-independent, and multiplexed characterization of amyloid plaques by MALDI MS/MS imaging using iprm-PASEF
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Meyer, Larissa Chiara; Li, Mujia Jenny; Meier, Nadine; Vollmer-Kary, Beate; Feilen, Tobias; Audebert, Julie; Kurowski, Konrad; Singer, Stephan; Bronsert, Peter; Föll, Melanie Christine;
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Analytical and Bioanalytical Chemistry, 1-14
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https://doi.org/10.1007/s00216-025-06277-1
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2026
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Identifying space-resolved proteins of the murine thymus, by combining MALDI-MSI and proteomics
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Aguilan, Jennifer T; Madrid-Aliste, Carlos; Fischer, Joshua; Lagou, Maria K; Sidoli, Simone; Karagiannis, George S;
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Life Science Alliance, 9, 1,
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https://doi.org/10.26508/lsa.202503205
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2026
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Spatial Proteomics of the Normal Breast Collagen Stroma: Links to Density and Body Mass Index
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Dunne, Jaclyn B; Rujchanarong, Denys; Park, Yeonhee; Spruill, Laura; Jensen-Smith, Heather; Schwamborn, Kristina; Hollingsworth, Michael A; Macdonald, Jade K; Hulahan, Taylor S; Taylor, Harrison B; Sandusky, George E; Mehta, Anand S; Drake, Richard R; Ford, Marvella E; Nakshatri, H; Angel, Peggi M
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J Proteome Res, 25, 3, 1403-1419
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https://doi.org/10.1021/acs.jproteome.5c00623
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2026
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Multimodal laser-based imaging methods for the investigation of adverse skin reactions to black tattoos at an elemental and molecular level
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Wolf, Carina; Heuckeroth, Steffen; Van Der Bent, Sebastiaan; De Vega, Raquel Gonzalez; Den Hartog, Wietske; Clases, David; Karst, Uwe;
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Talanta, 299, 129050
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https://doi.org/10.1016/j.talanta.2025.129050
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2025
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MALDI-MSI-Based Spatial Metabolite Mapping of Rheum tanguticum Roots across Growth Years Reveals Functional Food Potential
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Tao, WANG; Shuo, ZHAO; Jianan, LI; Bo, WANG; Huiyuan, MA; Zengrong, YE; Guoying, ZHOU;
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Food Bioscience, 74, 107984
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https://doi.org/10.1016/j.fbio.2025.107984
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2025
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Comparative Evaluation of Hyperpolarized [13C] pyruvate and [13C] lactate for Imaging Neuronal and Glioma Metabolism
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Chen, Jun; Zaidi, Maheen; Chaudhary, Jaideep; Erfani, Zohreh; Al Nemri, Sarah; Plautz, Erik J; Wen, Xiaodong; Seeley, Erin H; Bartnik-Olson, Brenda L; Corbin, Ian R;
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ACS sensors, 11, 1, 489-499
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https://doi.org/10.1021/acssensors.5c03203
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2025
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Single-cell and spatially resolved omics reveal transcriptional and metabolic signatures of ovarian endometriomas
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Qi, Yujuan; Chen, Xia; Zheng, Sen; Wu, Tiantian; Li, Zhenbei; Cheng, Jie; Yang, Xinhui; Tao, Wei; Huang, Qiuru; Gu, Juan;
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Nature Communications, 16, 11539
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https://doi.org/10.1038/s41467-025-66706-8
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2025
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Altered glycolipid metabolism during acute kidney injury exacerbates renal inflammation
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Osada, Akinori; Tanaka, Miyako; Sugiura, Yuki; Yuan, Xunmei; Yamashita, Shinji; Ochi, Kozue; Kohda, Hiro; Ito, Ayaka; Go, Shiori; Okajima, Tetsuya;
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Scientific Reports, 16, 147
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https://doi.org/10.1038/s41598-025-28897-4
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2025
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Imaging Mass Spectrometry Reveals In Situ Conversion of Glucosinolates to Bioactive Isothiocyanates in Cabbage
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Shikano, Hitomi; Nakasato, Yuka R; Tian, Rui; Shinoda, Tetsuro; Taira, Shu;
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Journal of Agricultural and Food Chemistry, 74, 1, 706-712
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https://doi.org/10.1021/acs.jafc.5c10194
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2025
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Engineered Reactive Interfaces Enable Mass Spectrometry Imaging of Multiple Thiols for Decoding PFOS-Induced Redox Dysregulation
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Xu, Hongmei; Lam, Thomas Ka-Yam; Zhang, Simin; Guo, Lei; Wong, Chris Kong Chu; Dong, Chuan; Cai, Zongwei;
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Analytical Chemistry, 98, 1, 884-893
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https://doi.org/10.1021/acs.analchem.5c05993
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2025
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Filtration-Based Rapid ECM-Hydrogel Elimination Enables Robust MALDI MSI of Intestinal Organoids
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Zhang, Fangyuan; Shen, Xinxin; Yuan, Jie; Ye, Jiayi; Sui, Jian; Tao, Huimin; Xu, Jianfeng; Ye, Yang; Hu, Youhong; Wang, Bo;
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Analytical Chemistry, 98, 1, 571-580
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https://doi.org/10.1021/acs.analchem.5c05415
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2025
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Integrating Model-Based Reconstruction and Deep Learning for Accelerating Mass Spectrometry Imaging
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Anandakumar, Mithunjha; Trinklein, Timothy J; Rubakhin, Stanislav S; Sweedler, Jonathan V; Lam, Fan;
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Analytical Chemistry, 97, 45, 25120-25128
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https://doi.org/10.1021/acs.analchem.5c04075
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2025
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Mass Spectrometry Imaging Reveals the Distribution of a GABRG2 Targeting Antisense Oligonucleotide and Its Functional Effect in Rat Brain
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van der Vloet, Laura; Mohren, Ronny; Bouillod, Christophe; Da Violante, Georges; Isin, Emre M; Heeren, Ron MA; Barbier Saint Hilaire, Pierre; Vandenbosch, Michiel;
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ACS Chemical Neuroscience, 16, 20, 4064-4075
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https://doi.org/10.1021/acschemneuro.5c00524
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2025
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Unveiling spatial distribution of flavonoids and polysaccharides in four-year-old Polygonatum cyrtonema Hua rhizome via MALDI-MSI
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Khan, Yasmin; Liu, Lin; Huang, Junru; Zeb, Aurang; Sun, Xu; Cai, Yongping; Fan, Honghong;
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International Journal of Biological Macromolecules, 309, 2, 142694
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https://doi.org/10.1016/j.ijbiomac.2025.142694
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2025
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Spatial metabolomics analysis of Bozhou Paeoniae Radix Alba during different harvest periods based on MALDI-MSI
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Deng, Chenyang; Chen, Kaiwen; Wang, Mengting; Zhang, Yuting; Rong, Yu; Jin, Chuanshan; Wu, Deling; Liu, Junling; Li, SuLiang; Zhou, Qiumei;
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Phytomedicine, 150, 157698
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https://doi.org/10.1016/j.phymed.2025.157698
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2025
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Spatial Molecular Imaging of the Glycome Using Mass Spectrometry
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Ribas, Roberto A; Paolasso, Franca Bucco; Ryan, Alison M; Sanchez, Manuel R; Soto, Charles M; Caffee, Scarlett I; Larson, Reece C; Allison, Derek B; Gentry, Matthew S; Sun, Ramon C;
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Journal of Visualized Experiments, 225, e69154
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https://doi.org/10.3791/69154
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2025
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A MALDI-MSI-based approach to characterize the spatial distribution of cylindrospermopsin and lipid alterations in rat intestinal tissue
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Casas-Rodríguez, Antonio; López-Vázquez, Cristina María; Guzmán-Guillén, Remedios; Ayala, Nahúm; Cameán, Ana María; Jos, Angeles; Chicano-Gálvez, Eduardo;
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Chemico-Biological Interactions, 412, 111479
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https://doi.org/10.1016/j.cbi.2025.111479
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2025
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Deciphering the Three-Dimensional Biomolecular Distribution in the Alzheimer’s Disease Brain: A Multiomic Approach Integrating Immunohistochemistry with MALDI MS Imaging
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Lu, Kelly H; Zhang, Hua; Yagnik, Gargey B; Lim, Mark J; Rothschild, Kenneth J; Li, Wei; Schneider, Andrew J; Puglielli, Luigi; Li, Lingjun;
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Analytica Chimica Acta, 1379, 344721
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https://doi.org/10.1016/j.aca.2025.344721
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2025
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Integrating ion mobility spectrometry and mass spectrometry imaging for characterizing the distribution of biologically active disaccharide isomers
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Zeng, Ting; Zheng, Xueyun; Zemaitis, Kevin; Velickovic, Dusan; Anderton, Christopher R;
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Journal of the American Society for Mass Spectrometry, 36, 8, 1729-1736
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https://doi.org/10.1021/jasms.5c00101
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2025
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Sequential Detection of Biomolecules in Formalin-fixed, Paraffin-embedded Samples with Mass Spectrometry Imaging
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Seeley, Erin H; Stolley, Danielle L; Casasent, Anna K; Gamal, Basant T; Ferri-Borgogno, Sammy; Burks, Jared K;
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Journal of Visualized Experiments, 224, e68618
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https://doi.org/10.3791/68618
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2025
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Spatial Profiling of Elements through Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging
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Stopka, Sylwia A; Bodineau, Clément; Baquer, Gerard; Lin, Jia-Ren; Hossain, Md Amin; Martinez, Camilla J; Regan, Michael S; Ruiz, Daniela; Fletcher, Stecia-Marie; Pourquié, Olivier;
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Analytical Chemistry, 97, 45, 25334-25345
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https://doi.org/10.1021/acs.analchem.5c05632
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2025
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Spatially mapping neuropeptide isomers via MALDI trapped ion mobility MS imaging
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Okyem, Samuel; Trinklein, Timothy J; Rubakhin, Stanislav S; Sweedler, Jonathan V;
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Analytical chemistry, 97, 42, 23370-23380
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https://doi.org/10.1021/acs.analchem.5c04297
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2025
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Investigating the Quantitative Structure–Ionization Efficiency Relationship of Small Molecules and Lipids in the Presence of Ammonium Fluoride in MALDI-TIMS-QTOF Mass Spectrometry Imaging
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Nikolopoulou, Varvara; Stem, Arthur; Vasiliou, Vasilis; Aalizadeh, Reza;
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Journal of the American Society for Mass Spectrometry, 36, 11, 2460-2469
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https://doi.org/10.1021/jasms.5c00211
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2025
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Enhanced spatial proteomics and metabolomics from a single tissue section using MALDI-MSI and LCM-microPOTS platforms
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Velickovic, Marija; Day, Le Z; Zemaitis, Kevin J; Attah, Isaac Kwame; Burnum-Johnson, Kristin E; Anderton, Christopher R; Velickovic, Dusan;
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Analytical Chemistry, 97, 44, 24715-24723
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https://doi.org/10.1021/acs.analchem.5c05005
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2025
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Spatial Mapping of Gangliosides and Proteins in Amyloid Beta Plaques at Cellular Resolution Using Mass Spectrometry Imaging and MALDI‐IHC
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Good, Christopher J; Bowman, Andrew P; Klein, Corinna; Awwad, Khader; Buck, Wayne R; Yang, Junhai; Wagner, David S;
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Journal of Mass Spectrometry, 60, 9, e5161
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https://doi.org/10.1002/jms.5161Digital Object Identifier (DOI)
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2025
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Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence
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Piyadasa, Hadeesha; Oberlton, Benjamin; Ribi, Mikaela; Ranek, Jolene S; Averbukh, Inna; Leow, Ke; Amouzgar, Meelad; Liu, Candace C; Greenwald, Noah F; McCaffrey, Erin F;
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Cancer Cell, 44, 1, 112-128
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https://doi.org/10.1016/j.ccell.2025.11.006
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2025
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Neonatal systemic gene therapy restores cardiorespiratory function in a rat model of Pompe disease
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Fuller, David D; Rana, Sabhya; Thakre, Prajwal P; Benevides, Ethan S; Pope, Megan K; Todd, Adrian G; Jensen, Victoria N; Vaught, Lauren; Cloutier, Denise A; Ribas, Roberto A;
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Molecular Therapy, 33, 9, 4276-4289
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https://doi.org/10.1016/j.ymthe.2025.06.022
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2025
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Spatial metabolic gradients in the liver and small intestine
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Samarah, Laith Z; Zheng, Clover; Xing, Xi; Lee, Won Dong; Afriat, Amichay; Chitra, Uthsav; MacArthur, Michael; Lu, Wenyun; Jankowski, Connor SR; Ma, Cong;
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Nature, 648, 182-190
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https://doi.org/10.1038/s41586-025-09616-5
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2025
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Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke
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Wang, Gangqi; van den Berg, Bernard M; Kostidis, Sarantos; Pinkham, Kelsey; Jacobs, Marleen E; Liesz, Arthur; Giera, Martin; Rabelink, Ton J;
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Nature Metabolism, 7, 1791-1800
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https://doi.org/10.1038/s42255-025-01340-8
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2025
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One Section, Two Worlds: Single-Cell Integration of MALDI-MSI and Spatial Transcriptomics on the Same Single Tissue Section
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Hendriks, Tim FE; Eijkel, Gert B; Visvikis, Theodoros; Balluff, Benjamin; Heeren, Ron MA; Cuypers, Eva;
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Sci Rep, 15, 42660
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https://doi.org/10.1038/s41598-025-26735-1
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2025
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MALDI-TIMS-MS2 Imaging and Annotation of Natural Products in Fungal-Bacterial Coculture
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Shepherd, Robert A; Luu, Gordon T; Sanchez, Laura M;
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Analytical Chemistry, 97, 35, 18867-18872
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https://doi.org/10.1021/acs.analchem.5c02787
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2025
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Resolving multi-image spatial lipidomic responses to inhaled toxicants by machine learning
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Stevens, Nathanial Chase; Shen, Tong; Martinez, Joshua; Evans, Veneese JB; Domanico, Morgan C; Neumann, Elizabeth K; Van Winkle, Laura S; Fiehn, Oliver;
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Nature Communications, 16, 2954
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https://doi.org/10.1038/s41467-025-58135-4
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2025
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Geographic characterization of RPE structure and lipid changes in the PEX1-p. Gly844Asp mouse model for Zellweger spectrum disorder.
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Omri, Samy; Argyriou, Catherine; Pryce, Rachel; Di Pietro, Erminia; Chaurand, Pierre; Braverman, Nancy E;
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Journal of Lipid Research, 66, 4, 100771
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https://doi.org/10.1016/j.jlr.2025.100771
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2025
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Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum
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Koutarapu, Srinivas; Ge, Junyue; Dulewicz, Maciej; Srikrishna, Meera; Szadziewska, Alicja; Wood, Jack; Blennow, Kaj; Zetterberg, Henrik; Michno, Wojciech; Ryan, Natalie S;
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Nature Communications, 16, 3889
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https://doi.org/10.1038/s41467-025-59085-7
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2025
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Isotope-encoded spatial biology identifies plaque-age-dependent maturation and synaptic loss in an Alzheimer’s disease mouse model
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Wood, Jack I; Dulewicz, Maciej; Ge, Junyue; Stringer, Katie; Szadziewska, Alicja; Desai, Sneha; Koutarapu, Srinivas; Hajar, Haady B; Blennow, Kaj; Zetterberg, Henrik;
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Nature Communications, 16, 8170
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https://doi.org/10.1038/s41467-025-63328-y
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2025
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Exploring the Abeta Plaque Microenvironment in Alzheimer's Disease Mice by Multimodal Lipid-Protein-Histology Imaging on a Benchtop Mass Spectrometer
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Mueller, Elisabeth; Enzlein, Thomas; Niemeyer, Dagmar; von Ammon, Livia; Stumpo, Katherine; Biber, Knut; Klein, Corinna; Hopf, Carsten;
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Pharmaceuticals, 18, 2, 252
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https://doi.org/10.3390/ph18020252
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2025
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Met-ID: An Open-Source Software for Comprehensive Annotation of Multiple On-Tissue Chemical Modifications in MALDI-MSI
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Bjärterot, Patrik; Nilsson, Anna; Shariatgorji, Reza; Vallianatou, Theodosia; Kaya, Ibrahim; Svenningsson, Per; Käll, Lukas; Andrén, Per E;
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Analytical Chemistry, 97, 16, 9033-9041
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https://doi.org/10.1021/acs.analchem.5c00633
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2025
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Improving MALDI Mass Spectrometry Imaging Performance: Low-Temperature Thermal Evaporation for Controlled Matrix Deposition and Improved Image Quality
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Mahamdi, Toufik; Serna, Cristina Gomez; Giné, Roger; Rofes, Jordi; Mohammed, Shad Arif; Rafols, Pere; Correig, Xavier; Garcia-Altares, Maria; Hopf, Carsten; Iakab, Stefania Alexandra;
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J. Am. Soc. Mass Spectrom. 2025, 36, 5, 1100–1110
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https://doi.org/10.1021/jasms.5c00015
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2025
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Virtual Staining of Label-Free Tissue in Imaging Mass Spectrometry
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Zhang, Yijie; Huang, Luzhe; Pillar, Nir; Li, Yuzhu; Migas, Lukasz G; Van de Plas, Raf; Spraggins, Jeffrey M; Ozcan, Aydogan;
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ScienceAdvances, 11, 31
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DOI: 10.1126/sciadv.adv0741
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2025
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Aminated cinnamic acid analogs as dual polarity matrices for high spatial resolution MALDI imaging mass spectrometry
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Dufresne, Martin; Migas, Lukasz; Djambazova, Katerina; Van de Plas, Raf; Spraggins, Jeffrey
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Analytica Chimica Acta, 1371, 344423
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https://doi.org/10.1016/j.aca.2025.344423
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2025
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Direct transfer of multicellular tumor spheroids grown in agarose microarrays for high-throughput mass spectrometry imaging analysis
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Liu, Y., Johnson, J., Zhang, H. et al.
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Anal Bioanal Chem, 417, 3021-3031
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https://doi.org/10.1007/s00216-025-05843-x
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2025
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Deep MALDI-MS Spatial Omics guided by Quantum Cascade Laser Mid-infrared Imaging Microscopy
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Gruber, L.; Schmidt, S.; Enzlein, T. et al.
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Nature Communications, 16, 4759
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https://doi.org/10.1038/s41467-025-59839-3
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2025
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The Impact of the Mass Analyzer and Tissue Section Thickness on Spatial N-Glycomics with MALDI-MSI
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Velickovic, Dusan; Velickovic, Marija; O’Connor, Christopher L; Bitzer, Markus; Anderton, Christopher;
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Journal of the American Society for Mass Spectrometry, 36, 4, 823-828
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https://doi.org/10.1021/jasms.4c00494
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2025
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Comprehensive Metabolite Profiling in Single-Cell Systems via Dual-Modal MALDI-Mass Spectrometry Imaging
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Yuan, Jie; Li, Xiafei; Shen, Xinxin; Xiong, Pei; Zhu, Nanlin; Ye, Yang; Liu, Jia;
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Analytical Chemistry, 97, 16, 8729-8737
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https://doi.org/10.1021/acs.analchem.4c05480
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2025
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Exploring 6-aza-2-Thiothymine as a MALDI-MSI Matrix for Spatial Lipidomics of Formalin-Fixed Paraffin-Embedded Clinical Samples
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Porto, Natalia Shelly; Serrao, Simone; Bindi, Greta; Monza, Nicole; Fumagalli, Claudia; Denti, Vanna; Piga, Isabella; Smith, Andrew;
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Metabolites, 15, 8, 531
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https://doi.org/10.3390/metabo15080531
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2025
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Quantitative MALDI imaging of aspirin metabolites in mouse models of triple-negative breast cancer
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Hahm, Tae-Hun; Brown, Dalton R; Tressler, Caitlin M; Tran, Thao; Ly, Alice; Pathak, Arvind P; McMahon, Michael T; Glunde, Kristine;
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Theranostics, 15, 18, 9359-9374
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https://doi.org/10.7150/thno.116819
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2025
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Photocleavable Mass-Tagged Oligonucleotide Probes for Multiplexed and Multiomic Tissue Imaging of Targeted Transcripts
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Bell, Jonathan M; Yagnik, Gargey; Dettori, Leonardo G; Carvalho, Philip; Wan, Zhi; Rothschild, Kenneth J; Lim, Mark J;
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Journal of the American Society for Mass Spectrometry, 36, 8, 1621-1640
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https://doi.org/10.1021/jasms.5c00057
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2025
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Optimization of Collagenase Proteomics for Improved Mass Spectrometry Imaging Peptide Identification
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Macdonald, Jade K; Zambrzycki, Stephen C; Taylor, Harrison B; Dunne, Jaclyn B; Quick, Montana; Mehta, Anand S; Drake, Richard R; Angel, Peggi M;
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Analytical Chemistry, 97, 14, 7672-7681
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https://doi.org/10.1021/acs.analchem.4c04818
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2025
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Single-Cell Multiomic MALDI-MSI Analysis of Lipids and N-Glycans through Affinity Array Capture
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Dressman, James W; Bayram, Muhammed F; Angel, Peggi M; Drake, Richard R; Mehta, Anand S;
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Analytical Chemistry, 97, 24, 12493-12502
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https://doi.org/10.1021/acs.analchem.4c06233
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2025
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Infrared laser imaging for tissues and cells
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Zhang, Miao; Wang, Peng; Dreisbach, Domenic; Tague, Thomas;
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Reporters, Contrast Agents, and Molecular Probes for Biomedical Applications XVI, 13339, 24-29
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https://doi.org/10.1117/12.3050054
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2025
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Application of a Multiomics Imaging Workflow to Explore Asparlas Treatment in Solid Tumors
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van der Vloet, Laura; Mohren, Ronny; Bouillod, Christophe; Heeren, Ron MA; Vandenbosch, Michiel; Barbier Saint Hilaire, Pierre;
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Analytical Chemistry, 97, 24. 12736-12745
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https://doi.org/10.1021/acs.analchem.5c01503
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2025
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Mass spectrometry imaging reveals alterations in protein and N-glycan molecular signatures in endometriosis tissues: Lin et al.
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Lin, Monica; Seeley, Erin H; Ledet, Suzanne; Salazar, Christina; Breen, Michael T; Eberlin, Livia S;
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Analytical and Bioanalytical Chemistry, 417, 4133-4145
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https://doi.org/10.1007/s00216-025-05930-z
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2025
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Permeation of Nicotinamide Mononucleotide (NMN) in an Artificial Membrane as a Cosmetic Skin Permeability Test Model
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Betsuno, Risako; Yamane, Takuya; Tsuji, Hiroko; Nakajima, Yu; Imai, Momoko; Bamba, Takeshi; Uchiyama, Susumu;
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Journal of Cosmetic Dermatology, 24, 5, e70222
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https://doi.org/10.1111/jocd.70222
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2025
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MALDI Imaging and Spatial SILAC Proteomics of Three-Dimensional Multicellular Spheroids Dynamically Dosed with Doxorubicin-Encapsulating Liposomes
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Lopez, Arbil; Holbrook, Joseph H; Hummon, Amanda B;
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Analytical Chemistry, 97, 21, 11239-11248
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https://doi.org/10.1021/acs.analchem.5c01309
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2025
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Machine learning-assisted MALDI-MSI to characterize hippocampal subregion lipid and purine metabolic alterations in depression-related dry eye disease
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Minsi, Xie; Qibo, Deng; Yu, Huang; Dongdong, Li; Pei, Liu; Qianhong, Liu; Junxian, Lei; Yijing, Yang; Houpan, Song; Sainan, Tian;
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Analytical Methods, 17, 6637-6655
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https://doi.org/10.1039/D5AY00675A
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2025
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Comprehensive High-Spatial-Resolution Imaging Metabolomics Workflow for Heterogeneous Tissues
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Diao, Xin; Wang, Jianing; Xie, Chengyi; Chen, Leijian; Lam, Thomas Ka-Yam; Zhu, Lin; Cai, Zongwei;
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Analytical Chemistry, 97, 20, 10561-10569
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https://doi.org/10.1021/acs.analchem.4c05410
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2025
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Maximizing data coverage through eight sequential mass spectrometry images of a single tissue section
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Seeley, Erin H;
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Journal of the American Society for Mass Spectrometry, 36, 5, 1148-1157
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https://doi.org/10.1021/jasms.5c00032
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2025
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Glycolipids implicated as mediators of clinically visible retinal pigment epithelial migration in age-related macular degeneration
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Wang, Zhen; Anderson, David MG; Messinger, Jeffrey D; Curcio, Christine A; Schey, Kevin L;
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Proceedings of the National Academy of Sciences, 122, 29, e2503191122
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https://doi.org/10.1073/pnas.2503191122
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2025
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Glycogen drives tumour initiation and progression in lung adenocarcinoma
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Clarke, Harrison A; Hawkinson, Tara R; Shedlock, Cameron J; Medina, Terrymar; Ribas, Roberto A; Wu, Lei; Liu, Zizhen; Ma, Xin; Xia, Yi; Huang, Yu;
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Nature metabolism, 7, 952-965
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https://doi.org/10.1038/s42255-025-01243-8
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2025
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Spatial mapping of the brain metabolome lipidome and glycome
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Clarke, Harrison A; Ma, Xin; Shedlock, Cameron J; Medina, Terrymar; Hawkinson, Tara R; Wu, Lei; Ribas, Roberto A; Keohane, Shannon; Ravi, Sakthivel; Bizon, Jennifer L;
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Nature Communications, 16, 1, 4373
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https://doi.org/10.1038/s41467-025-59487-7
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2025
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AI-driven framework to map the brain metabolome in three dimensions
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Ma, Xin; Shedlock, Cameron J; Medina, Terrymar; Ribas, Roberto A; Clarke, Harrison A; Hawkinson, Tara R; Dande, Praveen K; Golamari, Hari KR; Wu, Lei; Ziani, Borhane EC;
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Nature metabolism, 7, 842-853
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https://doi.org/10.1038/s42255-025-01242-9
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2025
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Spatial patterns of hepatocyte glucose flux revealed by stable isotope tracing and multi-scale microscopy
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Habashy, Aliyah; Acree, Christopher; Kim, Keun-Young; Zahraei, Ali; Dufresne, Martin; Phan, Sebastien; Cutler, Melanie; Patterson, Emilee; Mulligan, Alexandra G; Burkewitz, Kristopher;
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Nature Communications, 16, 5850
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https://doi.org/10.1038/s41467-025-60994-w
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2025
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Differential extracellular matrix proteomic signatures in colorectal tumors from Appalachian and non‑Appalachian patients
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Sougiannis, Alexander T; Taylor, Harrison B; Zambrzycki, Stephen C; Conroy, Lindsey; Strubler, Rachel; Edge, Christin; Drake, Richard R; Wallace, Kristin; Allison, Derek; Lee, Eun;
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Oncology Letters, 30, 3, 1-14
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https://doi.org/10.3892/ol.2025.15159
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2025
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Deciphering distinct spatial alterations in N-glycan expression profiles in the spinal cord and brain of male rats in a neuropathic pain model
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Jang, Hyun Jun; Shin, Juhee; Lee, Sangkyu; Lee, Boyoung; Kim, Dong Woon;
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Cellular & Molecular Biology Letters, 30, 31
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https://doi.org/10.1186/s11658-025-00709-7
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2025
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Metabolomic reprogramming of the tumor microenvironment by dual arginase inhibitor OATD-02 boosts anticancer immunity
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Grzybowski, Marcin Mikołaj; Uçal, Yasemin; Muchowicz, Angelika; Rejczak, Tomasz; Kikulska, Agnieszka; Głuchowska, Katarzyna Maria; Szostakowska-Rodzoś, Małgorzata; Zagożdżon, Agnieszka; Bausbacher, Tobias; Tkaczyk, Agnieszka;
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Scientific Reports, 15, 1, 18741
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https://doi.org/10.1038/s41598-025-03446-1
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2025
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Urinary extracellular vesicle N-glycomics identifies diagnostic glycosignatures for bladder cancer
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Li, Yang; Fu, Bin; Wang, Maoyu; Chen, Weiyu; Fan, Jiawei; Li, Yueyue; Liu, Xuejiao; Wang, Jun; Zhang, Zhensheng; Lu, Haojie;
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Nature Communications, 16, 2292
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https://doi.org/10.1038/s41467-025-57633-9
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2025
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Impact of excess activin A on the lipids, metabolites, and steroids of adult mouse reproductive organs
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Hutchison, Jennifer C; Trim, Paul J; Whiley, Penny AF; Handelsman, David J; Snel, Marten F; Groome, Nigel P; Hedger, Mark P; Loveland, Kate L;
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Endocrinology, 166, 5, bqaf054
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https://doi.org/10.1210/endocr/bqaf054
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2025
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Porcine Sub-Retinal Pigment Epithelium Deposits: A Model for Dry Age-Related Macular Degeneration With Comparison to Human Drusen
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Shaw, Erika M; Anderson, David M; Periasamy, Ramesh; Schey, Kevin L; Curcio, Christine A; Lipinski, Daniel M;
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Investigative Ophthalmology & Visual Science, 66, 18
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https://doi.org/10.1167/iovs.66.3.18
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2025
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Spatial Proteomics by Parallel Accumulation‐Serial Fragmentation Supported MALDI MS/MS Imaging: A First Glance Into Multiplexed and Spatial Peptide Identification
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Li, M. J.; Meyer, L. C.; Meier, N. et al.
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Rapid Communications in Mass Spectrometry, 39, 9, e10006
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https://doi.org/10.1002/rcm.10006
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2025
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Visualization and Spatial Mapping of PFAS in the Edible Storage Root of Radish
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Zuo, Y.; Zhang, W.
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Journal of Hazardous Materials Letters, 6, 100141
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https://doi.org/10.1016/j.hazl.2025.100141
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2025
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Mass‐Guided Single‐Cell MALDI Imaging of Low‐Mass Metabolites Reveals Cellular Activation Markers
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Cairns, J. L.; Huber, J.; Lewen, A. et al.
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Advanced Science, 12, 5, 2410506
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https://doi.org/10.1002/advs.202410506
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2025
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Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues
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Lee, Y.; Kaya, I.; Wik, E. et al.
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Analytical Chemistry, 97, 2, 1338-1346
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https://doi.org/10.1021/acs.analchem.4c05665
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2025
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Advancing Atherosclerosis Research: The Power of Lipid Imaging with MALDI-MSI
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Bookmeyer, C. HM; Blanchar, F X. C.; Masana, L. et al.
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Atherosclerosis, 119130, in press
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https://doi.org/10.1016/j.atherosclerosis.2025.119130
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2025
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The spatiotemporal changes of metabolites in Pinellia ternata at different development stages by MALDI‐MSI
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Pei, Y.; Feng, X.; Liu, Z. et al.
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Physiologia Plantarum, 177, 1, e70049
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https://doi.org/10.1111/ppl.70049
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2025
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Metabolic Atlas of Human Eyelid Infiltrative Basal Cell Carcinoma
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Huang, Y.; He, C.; Hu, Q. et al.
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Investigative Ophthalmology & Visual Science, 66, 1, 11
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https://doi.org/10.1167/iovs.66.1.11
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2025
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Environmental exposure to common pesticide induces synaptic deficit and social memory impairment driven by neurodevelopmental vulnerability of hippocampal parvalbumin interneurons
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Di Re, J.; Koff, L.; Avchalumov, Y. et al.
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Journal of Hazardous Materials, 485, 136893
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https://doi.org/10.1016/j.jhazmat.2024.136893
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2025
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Impact of aerobic exercise on brain metabolism: Insights from spatial metabolomic analysis
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Zheng, J.; Luo, W.; Kong, C. et al.
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Behavioural Brain Research, 478, 115339
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A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment
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Zhu, B.; Bai, Y.; Yeo, Y. et al.
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Nature Communications, 16, 1, 1230
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https://doi.org/10.1038/s41467-025-56237-7
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The structure of Shigella virus Sf14 reveals the presence of two decoration proteins and two long tail fibers
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Subramanian, S.; Kerns, H. R.; Braverman, S. G. et al.
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Communications Biology, 8, 1, 222
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Mass Spectrometry Imaging in Diagnostic and Toxicologic Pathology for Label-Free Detection of Molecules—From Basics to Practical Applications
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Vezzali, E.; Becker, M.; Romero-Palomo, F. et al.
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Toxicologic Pathology, in press
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https://doi.org/10.1177/01926233241311269
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2025
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Mass Spectrometry-Based Spatial Multiomics Revealed Bioaccumulation Preference and Region-Specific Responses of PFOS in Mice Cardiac Tissue
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Shi, R.; Chen, Y.; Wu, W. et al.
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Environmental Science & Technology, 59, 4, 1957-1968
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https://doi.org/10.1021/acs.est.4c09874
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2025
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Spatiotemporal landscape of kidney in a mouse model of hyperuricemia at single‐cell level
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Chang, H.; Tao, Q.; Wei, L. et al.
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The FASEB Journal, 39, 2, e70292
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Resolving tissue complexity by multimodal spatial omics modeling with MISO
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Coleman, K.; Schroeder, A.; Loth, M. et al.
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Nature methods, 1-9
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https://doi.org/10.1038/s41592-024-02574-2
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Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2
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Rasmussen, C. L. M.; Frederiksen, S. F.; Heegaard, C. W. et al.
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Fluids and Barriers of the CNS, 22, 1, 13
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https://doi.org/10.1186/s12987-025-00621-4
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2025
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Tigulixostat Alleviates Hyperuricemic Nephropathy by Promoting M2 Macrophage Polarization
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Xue, L.; Tao, Q.; Chang, H. et al.
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Journal of Inflammation Research, 18, 17-30
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https://doi.org/10.2147/JIR.S500101
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2025
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Subtilosin A production is influenced by surfactin levels in Bacillus subtilis
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Dinesen, C.; Vertot, M.; Jarmusch, S. A. et al.
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Microlife, 6, uqae029
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https://doi.org/10.1093/femsml/uqae029
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2025
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Study of association between embryo growth arrest (EGA) and atmospheric fine particulate matter pollution (PM2. 5) and spatial metabolomics of villi derived from pregnant women
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Bai, L.; Fu, P.; Dong, C. et al.
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Journal of Hazardous Materials, 485, 136833
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2025
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Sequential MALDI-HiPLEX-IHC and Untargeted Spatial Proteomics Mass Spectrometry Imaging to Detect Proteomic Alterations Associated with Tumour Infiltrating Lymphocytes
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Bindi, G.; Monza, N.; de Oliveira, G. S. et al.
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Journal of Proteome Research, 24, 2, 871-880
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https://doi.org/10.1021/acs.jproteome.4c00914
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2025
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Insight into distribution and composition of nonhuman N-Glycans in mammalian organs via MALDI-TOF and MALDI-MSI
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Guo, R.; Heijs, B.; Wang, W. et al.
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Carbohydrate Polymers, 351, 123065
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https://doi.org/10.1016/j.carbpol.2024.123065
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2025
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Visualizing the spatial distribution of metabolites in tomato fruit at different maturity stages by matrix-assisted laser desorption/ionization mass spectrometry imaging
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Sihui, G.; Chaochao, L.; Zhuping, Y. et al.
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Food Research International, 206, 115973
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https://doi.org/10.1016/j.foodres.2025.115973
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2025
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Comprehensive MALDI mass spectrometry imaging of tumor regions post-neoadjuvant therapy
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Xu, H.; Zhang, Q.; Yuan, J. et al.
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Anal Bioanal Chem 417, 2039–2046
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https://doi.org/10.1007/s00216-025-05785-4
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2025
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Coupling proteomics and lipidomics for insights into regulation of oat (Avena sativa) grain lipid synthesis
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Wai, C. D. L.; Leigh, D.; John, C. H. et al.
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Food Chemistry, 478, 143644
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N-linked fucosylated glycans are biomarkers for prostate cancer with a neuroendocrine and metastatic phenotype
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Ippolito, J. E.; Hartig, J. P.; Bejar, K. et al.
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Molecular Cancer Research, 23, 1, 59-70
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Loss of SPNS1, a lysosomal transporter, in the nervous system causes dysmyelination and white matter dysplasia
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Ichimura, Yoshinobu; Sugiura, Yuki; Katsuragi, Yoshinori; Sou, Yu-Shin; Uemura, Takefumi; Tamura, Naoki; Komatsu-Hirota, Satoko; Ueno, Takashi; Koike, Masato; Waguri, Satoshi;
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eLife, 13, RP99913
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2024
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An Updated Guide to the Identification, Quantitation, and Imaging of the Crustacean Neuropeptidome
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Wu, W.; Fields, L.; DeLaney, K. et al.
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Peptidomics: Methods and Strategies, 255-289
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6-Aza-2-Thiothymine as an Alternative Matrix for Spatial Proteomics with MALDI-MSI
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Denti, V.; Monza, N.; Bindi, G. et al.
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International Journal of Molecular Sciences, 25, 24, 13678
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2024
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The spatial distribution of components in Moringa oleifera (Lam) seed by matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI)
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Wang, T.; Wang, J.; Yang, S. et al.
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International Journal of Mass Spectrometry, 504, 117287
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https://doi.org/10.1016/j.ijms.2024.117287
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2024
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Quantitative MALDI-MS and Imaging of Fungicide Pyrimethanil in Strawberries with 2-Nitrophloroglucinol as an Effective Matrix
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McDonald, H.; Li, Q.; Ashaduzzaman, M. et al.
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Journal of the American Society for Mass Spectrometry, 35, 6, 1272-1281
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https://doi.org/10.1021/jasms.4c00066
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2024
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Accumulation of Bioactive Lipid Species in LPS-Induced Neuroinflammation Models Analysed with Multi-Modal Mass Spectrometry Imaging
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Razo, I. B.; Shea, K.; Allen, T. et al.
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International Journal of Molecular Sciences, 25, 22, 12032
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https://doi.org/10.3390/ijms252212032
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2024
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Analyzing noncovalent interactions between notoginseng saponins and lysozyme by deposition scanning intensity fading MALDI‐TOF mass spectrometry
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Zhao, X.; Ren, J.; Wang, Z. et al.
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Journal of Mass Spectrometry, 59, 7, e5058
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https://doi.org/10.1002/jms.5058
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2024
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Matrix-assisted laser desorption/ionization mass spectrometry imaging for quorum sensing
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Kuik, C.; van Hoogstraten, S. WG.; Arts, J. JC. et al.
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AMB Express, 14,1, 45
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https://doi.org/10.1186/s13568-024-01703-6
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2024
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Spatial metabolomics to discover hypertrophic scar relevant metabolic alterations and potential therapeutic strategies: A preliminary study
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Li, J.; Zeng, S.; Zhang, E. et al.
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Bioorganic Chemistry, 153, 107873
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https://doi.org/10.1016/j.bioorg.2024.107873
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2024
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Spatial resolution of renal amyloid deposits through MALDI-MSI: a combined digital and molecular approach to monoclonal gammopathies
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Bindi, G.; Smith, A.; Oliveira, G. et al.
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Journal of Clinical Pathology, 77, 6, 402-410
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2024
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