Biology at the Nanoscale: From Viruses to Amyloids
Explore recent leading-edge research using nanoscale infrared spectroscopy (AFM-IR) in the characterization of viruses and other biological samples.
Watch this exclusive presentation by Dmitry Kurouski, Ph.D. (Texas A&M University) about the complementary use of TERS and AFM-IR to investigate biological samples.
- Gain new insight into the ways that nanoIR—and AFM-IR, specifically—overcomes the limits of traditional biological imaging methods.
- Understand how to synthesize complementary information provided by TERS and AFM-IR in the study of viruses and other biological samples.
- Learn how AFM-IR and TERS together reveal new information about the composition, surface structure, and secondary structures of biological samples.
- Review detailed real-world research findings related to viruses, viral particles, and alpha-synuclein oligomers.
Explore the benefits of the complementary use of TERS and AFM-IR to investigate biological samples.
In this presentation, Dmitry Kurouski, Ph.D. (Texas A&M University) showcases his team's research and findings using TERS and AFM-IR to investigate viruses, viral particles, and alpha-synuclein oligomers. Presentation topics range from an exploration of how IR/nanoIR spectroscopy reveals a variety of infrared spectra in biological samples that are otherwise inaccessible by traditional raman microscopy methods, to a detailed discussion of the changes observed via a combination of AFM-IR and TERS in the secondary structural organization and surface structure information of populations of oligomers relative to their impact on the development of Parkinson's disease.
This illustrates that neither AFM-IR nor TERS is "better" than the other for the study of biological samples; rather, these two technologies possess different capabilities that demonstrate strong complementarity in terms of both the chemical information available and the achievable probing depth.
