Raman Microscopes


The SENTERRA II is a confocal Raman microscope designed for straightforward, non-stop operation. Its high degree of automation allows fast and easy Raman imaging for failure analysis, quality control and scientific research.

Always Calibrated.

Maximum Precision.

Efficiency from Simplicity

Your Raman Microscopy Companion: SENTERRA II

Introduction of the SENTERRA II | Product video
Our Raman application scientist presents the SENTERRA II and its features.
We know our audience

The secret to straightforward Raman micoscopy

Automation is the SENTERRA II's key feature. It allows the user to concentrate on the essential things: the analytical problem, the Raman measurement and more importantly, the results.

SENTERRA II technical features:

  • Fully automated hardware
  • One-click switching of 4 built-in lasers
  • SureCalTM calibration technology
  • Fast 3D Raman imaging
  • Automate your own workflows in minutes
  • Powerful analysis and identification tools
  • FT-Raman for minimized fluorescence in
    combination with FTIR instrumentation
SENTERRA II provides:
  • Smooth user experience
  • Research-grade performance
  • Superb wavenumber precision
  • Self-diagnosis and automated OQ/PQ
  • Virtually maintenance-free operation
  • 100% GMP & 21 CFR p11 compliance

SENTERRA II applications:

  • Pharmaceuticals
  • Material Science
  • Polymers & Plastics
  • Environmental
  • Forensics
Three Major Design Choices

Reproducibility, Precision and User-Safety in Raman Microscopy

First, the SENTERRA II is fully automated including self-diagnosis and instrument tests like OQ and PQ. Change a laser by a simple mouse-click and afterwards, filter and grating are adjusted automatically.

Second, to use this automation to its full extent, we rethought calibration and created the patented SureCalTM technology. It continuously recalibrates the device and allows permanent sub-wavenumber precision.

Third, it’s about user safety - especially when beginners or students are involved. A class 1 laser housing and interlock always protects the user of any harmful laser radiation.

Your Advantage in Science and Industry

SureCal Continuous Raman Calibration Technology

Naturally, the SENTERRA II offers excellent sensitivity combined with pristine spectral and Raman Imaging performance. But the real powerhouse of this confocal Raman microscope is our SureCalTM technology.

Let us briefly repeat one of the most important principles of Raman technology: External factors affect the optical and mechanical components in every Raman microscope, especially heat, component changes and vibrations. Ultimately, this induces wavenumber shifts, which must be compensated by regular recalibrations.

Thanks to SureCalTM, the SENTERRA II is the only Raman microscope that is always calibrated. Don't waste your valuable time with recalibration - start analyzing. No matter if it is a quick material identification or the collection of large data sets for PCA or other statistical methods.

Dedicate your Raman Microscope to Life-Science

Senterra II can also be configured with an inverted microscope without compromising any functionality. The inverted Raman microscope gives open access for sample handling, which is particularly favorable in characterization of live tissue and cells.

Besides cell research, the inverted microscope also brings advantages in researches like in vitro pharmaceutical verification and in situ Raman measurement that requests better access to the microscopic stage.

Take home message

Who it's for? Everyone!

We developed a powerful Raman microscopy platform for all kinds of applications. Its high degree of automation, compact size and efficient workflow, make the SENTERRA II an ideal tool to solve real world tasks in a quality control laboratory or to discover and pioneer in scientific research.

SENTERRA II Application Videos

API distribution in a pharmaceutical tablet by Raman microscopy.
LCD failure analysis within the material by confocal µ-Raman.
How Raman microscopy supports battery research and energy storage.
Particle Analysis in pharmaceutical manufacturing and quality control by Raman microscopy.
Multi layer polymer composite testing and layer determination by SENTERRA II.

OPUS Release 8.7  | SENTERRA II | Q3 2021

Highlight: Python Script Interface implemented into OPUS

In OPUS 8.7 SP1, we have made it easier to use customized data processing and evaluation methods with our new Python environment within OPUS. It opens a door for the users who need special algorithms for the data. The python script can be executed in OPUS right after the Raman measurement. Make the post-processing truly yours and enjoy all the power you can bring to the routine measurements with Python.

Highlight: High Performance Chemical Image Generation by New Adaptive K-means Clustering Function

We also released a new Raman data analysis function Adaptive K-means Clustering. It was created with the help of the build-in Python environment. With this new function, you can generate a chemical imaging directly after the measurement without the need of selecting specific Raman peak at all.  The system will sort the spectra into groups automatically and generates Raman images all by itself. For the applications that use a known sample, for instance a pharmaceutical tablet with several APIs, this function can provide the user Raman image immediately and save a lot of time. For the experiments of unknown samples, with the automatic Raman imaging method, users can tell at a glance if the sample is homogeneous or structured chemically.

Other new functions availa on SENTERRA II:

  • “Cluster ID” Function for Identification of Classes in 3D Spectral Data
  • "Find Particles" function now contains a novel particle detection method
  • SENTERRA II now operates under new OVP-X routine

Raman Literature Room

Learn more about our Raman products and solutions by downloading related literature.

Watch our Video: Spatial and Depth Resolution in Confocal Raman Microscopy & Imaging
Watch our Video: Raman Microscopy - Tutorial and Step-by-Step Demonstration